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Human CCL2/MCP-1 DuoSet ELISA, 15 Plate (1 KT)

货号: DY279 基本售价: 10120.7 元 规格: 1 KIT

产品信息

概述
货号DY279
别名
CCL2; MCAF; MCP-1
反应种属Human
目标/特异性Please see the product datasheet
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs6347 (Human); 20296 (Mouse); 24770 (Rat); 403981 (Canine);
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

In Vitro Inhibition of NFAT5-Mediated Induction of CCL2 in Hyperosmotic Conditions by Cyclosporine and Dexamethasone on Human HeLa-Modified Conjunctiva-Derived Cells
PLoS ONE, 2016;11(8):e0159983.
Species: Human
Sample Type: Cell Culture Supernates

Graphene-augmented nanofiber scaffolds demonstrate new features in cells behaviour
Sci Rep, 2016;6(0):30150.
Species: Human
Sample Type: Cell Culture Supernates

Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology.
Authors: Rosenberger A, Morrema T, Gerritsen W, van Haastert E, Snkhchyan H, Hilhorst R, Rozemuller A, Scheltens P, van der Vies S, Hoozemans J
J Neuroinflammation, 2016;13(1):4.
Species: Human
Sample Type: Cell Culture Supernates

Unfractionated Heparin Selectively Modulates the Expression of CXCL8, CCL2 and CCL5 in Endometrial Carcinoma Cells
Authors: A Doster, U Schwarzig, M Zygmunt, J Rom, F Schütz, H Fluhr
Anticancer Res, 2016;36(4):1535-44.
Species: Human
Sample Type: Cell Culture Supernates

Genetic polymorphisms of cell adhesion molecules in Behcet's disease in a Chinese Han population
Authors: M Zheng, L Zhang, H Yu, J Hu, Q Cao, G Huang, Y Huang, G Yuan, A Kijlstra, P Yang
Sci Rep, 2016;6(0):24974.
Species: Human
Sample Type: Cell Culture Supernates

Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis.
Authors: Bonapace L, Coissieux M, Wyckoff J, Mertz K, Varga Z, Junt T, Bentires-Alj M
Nature, 2015;515(7525):130-3.
Species: Human
Sample Type: Cell Culture Supernates

Macrophage activation in acute exacerbation of idiopathic pulmonary fibrosis.
Authors: Schupp J, Binder H, Jager B, Cillis G, Zissel G, Muller-Quernheim J, Prasse A
PLoS ONE, 2015;10(1):e0116775.
Species: Human
Sample Type: BALF

Characterization of In Vitro Engineered Human Adipose Tissues: Relevant Adipokine Secretion and Impact of TNF-alpha.
Authors: Aubin K, Safoine M, Proulx M, Audet-Casgrain M, Côté J, Tetu F, Roy A, Fradette J
PLoS ONE, 2015;10(9):e0137612.
Species: Human
Sample Type: Cell Culture Supernates

Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women.
Authors: McDonald C, Darling A, Conroy A, Tran V, Cabrera A, Liles W, Wang M, Aboud S, Urassa W, Fawzi W, Kain K
PLoS ONE, 2015;10(8):e0134619.
Species: Human
Sample Type: Plasma

Integrin alphaDbeta2 (CD11d/CD18) is expressed by human circulating and tissue myeloid leukocytes and mediates inflammatory signaling.
Authors: Miyazaki Y, Vieira-de-Abreu A, Harris E, Shah A, Weyrich A, Castro-Faria-Neto H, Zimmerman G
PLoS ONE, 2014;9(11):e112770.
Species: Human
Sample Type: Cell Culture Supernates

CD137 ligand signalling induces differentiation of primary acute myeloid leukaemia cells.
Authors: Cheng K, Wong S, Linn Y, Ho L, Chng W, Schwarz H
Br J Haematol, 2014;165(1):134-44.
Species: Human
Sample Type: Cell Culture Supernates

Human cytomegalovirus induces a biphasic inflammatory response in primary endothelial cells.
Authors: Jeffery H, Soderberg-Naucler C, Butler L
J Virol, 2013;87(11):6530-5.
Species: Human
Sample Type: cell culture supernate

Effects of high-dose cholecalciferol on serum markers of inflammation and immunity in patients with early chronic kidney disease.
Authors: Alvarez J, Zughaier S, Law J, Hao L, Wasse H, Ziegler T, Tangpricha V
Eur J Clin Nutr, 2013;67(3):264-9.
Species: Human
Sample Type: Serum

Lung collagens perpetuate pulmonary fibrosis via CD204 and M2 macrophage activation.
Authors: Stahl M, Schupp J, Jager B, Schmid M, Zissel G, Muller-Quernheim J, Prasse A
PLoS ONE, 2013;8(11):e81382.
Species: Human
Sample Type: Cell Culture Supernates

Urine VCAM-1 as a marker of renal pathology activity index in lupus nephritis.
Authors: Singh S, Wu T
Oncogene, 2012;14(4):R164.
Species: Human
Sample Type: Urine

Characterization and function of the human macrophage dopaminergic system: implications for CNS disease and drug abuse.
J Neuroinflammation, 2012;9(0):203.
Species: Human
Sample Type: Cell Culture Supernates

Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients.
Authors: Neuenschwander LC, Bittencourt H, Ribeiro AF, Teixeira AL, Teixeira MM, Teixeira JC, Nobre V
Clinics (Sao Paulo), 2011;66(10):1699-705.
Species: Human
Sample Type: Plasma

Focal increases of fetal macrophages in placentas from pregnancies with histological chorioamnionitis: potential role of fibroblast monocyte chemotactic protein-1.
Authors: Toti P, Arcuri F, Tang Z, Schatz F, Zambrano E, Mor G, Niven-Fairchild T, Abrahams VM, Krikun G, Lockwood CJ, Guller S
Am. J. Reprod. Immunol., 2011;65(5):470-9.
Species: Human
Sample Type: Cell Culture Supernates

Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis.
Authors: Ockinger J, Stridh P, Beyeen AD, Lundmark F, Seddighzadeh M, Oturai A, Sorensen PS, Lorentzen AR, Celius EG, Leppa V, Koivisto K, Tienari PJ, Alfredsson L, Padyukov L, Hillert J, Kockum I, Jagodic M, Olsson T
Genes Immun., 2010;11(2):142-54.
Species: Human
Sample Type: CSF

Activation of platelets by Aspergillus fumigatus and potential role of platelets in the immunopathogenesis of Aspergillosis.
Authors: Rodland EK, Ueland T, Pedersen TM, Halvorsen B, Muller F, Aukrust P, Froland SS
Infect. Immun., 2010;78(3):1269-75.
Species: Human
Sample Type: Cell Culture Supernates

Carbon dioxide inhalation causes pulmonary inflammation.
Authors: Abolhassani M, Guais A, Chaumet-Riffaud P, Sasco AJ, Schwartz L
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(4):L657-65.
Species: Human
Sample Type: Cell Culture Supernates

Oxidized alpha1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema.
Authors: Li Z, Alam S, Wang J, Sandstrom CS, Janciauskiene S, Mahadeva R
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;297(2):L388-400.
Species: Human
Sample Type: Cell Culture Supernates

Abnormalities in serum chemokine levels in euthymic patients with bipolar disorder.
Authors: Brietzke E, Kauer-SantAnna M, Teixeira AL, Kapczinski F
Brain Behav. Immun., 2009;23(8):1079-82.
Species: Human
Sample Type: Serum

Novel markers of inflammation identified in tumor necrosis factor receptor-associated periodic syndrome (TRAPS) by transcriptomic analysis of effects of TRAPS-associated tumor necrosis factor receptor type I mutations in an endothelial cell line.
Authors: Rebelo SL, Amel-Kashipaz MR, Radford PM, Bainbridge SE, Fiets R, Fang J, McDermott EM, Powell RJ, Todd I, Tighe PJ
Arthritis Rheum., 2009;60(1):269-80.
Species: Human
Sample Type: Cell Culture Supernates

Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy.
Authors: Tam FW, Riser BL, Meeran K, Rambow J, Pusey CD, Frankel AH
Cytokine, 2009;47(1):37-42.
Species: Human
Sample Type: Urine

Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation.
Authors: Weigt SS, Elashoff RM, Keane MP, Strieter RM, Gomperts BN, Xue YY, Ardehali A, Gregson AL, Kubak B, Fishbein MC, Saggar R, Ross DJ, Lynch JP, Zisman DA, Belperio JA
Am. J. Transplant., 2008;8(7):1512-22.
Species: Human
Sample Type: BALF

Increased serum levels of CCL11/eotaxin in schizophrenia.
Authors: Teixeira AL, Reis HJ, Nicolato R, Brito-Melo G, Correa H, Teixeira MM, Romano-Silva MA
Prog. Neuropsychopharmacol. Biol. Psychiatry, 2008;32(3):710-4.
Species: Human
Sample Type: Serum

Lipopolysaccharide-squamous cell carcinoma-monocyte interactions induce cancer-supporting factors leading to rapid STAT3 activation.
Authors: Kurago ZB, Lam-ubol A, Stetsenko A
Head Neck Pathol, 2008;2(1):1-12.
Species: Human
Sample Type: Cell Culture Supernates

Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes.
Authors: Chou SY, Weng JY, Lai HL, Liao F, Sun SH, Tu PH, Dickson DW, Chern Y
J. Neurosci., 2008;28(13):3277-90.
Species: Human
Sample Type: Cell Culture Supernates

Preadipocyte response and impairment of differentiation in an inflammatory environment.
Authors: Poulain-Godefroy O, Froguel P
Biochem. Biophys. Res. Commun., 2007;356(3):662-7.
Species: Human
Sample Type: Cell Culture Supernates

Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling.
Authors: Weindl G, Naglik JR, Kaesler S, Biedermann T, Hube B, Korting HC, Schaller M
J. Clin. Invest., 2007;117(12):3664-3672.
Species: Human
Sample Type: Cell Culture Supernates

Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis.
Authors: Wu T, Xie C, Wang HW, Zhou XJ, Schwartz N, Calixto S, Mackay M, Aranow C, Putterman C, Mohan C
J. Immunol., 2007;179(10):7166-75.
Species: Human
Sample Type: Urine

Modification of TLR-induced activation of human dendritic cells by type I IFN: synergistic interaction with TLR4 but not TLR3 agonists.
Authors: Walker J, Tough DF
Eur. J. Immunol., 2006;36(7):1827-36.
Species: Human
Sample Type: Cell Culture Supernates

Manipulation of host cytokine network by ticks: a potential gateway for pathogen transmission.
Authors: Hajnicka V, Vancova I, Kocakova P, Slovak M, Gasperik J, Slavikova M, Hails RS, Labuda M, Nuttall PA
Parasitology, 2005;130(0):333-42.
Species: Human
Sample Type: Saliva

Prediction of acute renal allograft rejection by urinary monokine induced by IFN-gamma (MIG).
Authors: Hauser IA, Spiegler S, Kiss E, Gauer S, Sichler O, Scheuermann EH, Ackermann H, Pfeilschifter JM, Geiger H, Grone HJ, Radeke HH
J. Am. Soc. Nephrol., 2005;16(6):1849-58.
Species: Human
Sample Type: Urine

Differential production of RANTES and MCP-1 in synovial fluid from the inflamed human knee.
Authors: Conti P, Reale M, Barbacane RC, Castellani ML, Orso C
Immunol. Lett., 2002;80(2):105-11.
Species: Human
Sample Type: Serum

Secretion of monocyte chemoattractant protein-1 by endothelial cells of the bovine corpus luteum: regulation by cytokines but not prostaglandin F2alpha.
Authors: Cavicchio VA, Pru JK, Davis BS, Davis JS, Rueda BR, Townson DH
Endocrinology, 2002;143(9):3582-9.
Species: Bovine
Sample Type: Cell Culture Supernates

背景CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.
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