Local Epidermal Growth Factor Receptor Signaling Mediates the Systemic Pathogenic Effects of Staphylococcus aureus Toxic Shock Syndrome
PLoS ONE, 2016;11(7):e0158969.
Species: Human
Sample Type: Cell Culture Supernates

Targeting mTOR and AREG with everolimus, sunitinib and sorafenib in HPV-positive and -negative SCC.
Authors: Aderhold C, Faber A, Umbreit C, Birk R, Weiss C, Sommer J, Hormann K, Schultz J
Anticancer Res, 2015;35(4):1951-9.
Species: Human
Sample Type: Cell Lysates

An integrative analysis of the tumorigenic role of TAZ in human non-small cell lung cancer.
Authors: Noguchi S, Saito A, Horie M, Mikami Y, Suzuki H, Morishita Y, Ohshima M, Abiko Y, Mattsson J, Konig H, Lohr M, Edlund K, Botling J, Micke P, Nagase T
Clin Cancer Res, 2014;20(17):4660-72.
Species: Human
Sample Type: Cell Culture Supernates

Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles.
Authors: Parnia S, Hamilton L, Puddicombe S, Holgate S, Frew A, Davies D
Respir Res, 2014;15(0):22.
Species: Human
Sample Type: Cell Culture Supernates

Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer.
Authors: Tanizaki J, Okamoto I, Okabe T, Sakai K, Tanaka K, Hayashi H, Kaneda H, Takezawa K, Kuwata K, Yamaguchi H, Hatashita E, Nishio K, Nakagawa K
Clin Cancer Res, 2012;18(22):6219-26.
Species: Human
Sample Type: cell culture supernate

A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).
Authors: Breshears L, Schlievert P, Peterson M
J Biol Chem, 2012;287(39):32578-87.
Species: Human
Sample Type: Cell Culture Supernates

Anti-Tumour Effects of a Specific Anti-ADAM17 Antibody in an Ovarian Cancer Model In Vivo.
Authors: Richards FM, Tape CJ, Jodrell DI, Murphy G
PLoS ONE, 2012;7(7):e40597.
Species: Human
Sample Type: Tissue Homogenates

The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer.
Authors: Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev IS, Tacheuchi S, Mouri H, Yamashita K, Ohtsubo K, Yano S
Clin. Cancer Res., 2011;17(11):3619-30.
Species: Human
Sample Type: ascitic fluid from mice bearing human gastric cancer tumors

Amphiregulin carboxy-terminal domain is required for autocrine keratinocyte growth.
Authors: Stoll SW, Johnson JL, Li Y, Rittie L, Elder JT
J. Invest. Dermatol., 2010;130(8):2031-40.
Species: Human
Sample Type: Cell Culture Supernates

Amphiregulin is much more abundantly expressed than transforming growth factor-alpha and epidermal growth factor in human follicular fluid obtained from patients undergoing in vitro fertilization-embryo transfer.
Authors: Inoue Y, Miyamoto S, Fukami T, Shirota K, Yotsumoto F, Kawarabayashi T
Fertil. Steril., 2009;91(4):1035-41.
Species: Human
Sample Type: Follicular Fluid

Identification of biomarkers in human head and neck tumor cell lines that predict for in vitro sensitivity to gefitinib.
Authors: Hickinson DM, Marshall GB, Beran GJ
Clin Transl Sci, 2009;2(3):183-92.
Species: Human
Sample Type: Cell Lysates

Cross-talk between estrogen receptor and epidermal growth factor receptor in head and neck squamous cell carcinoma.
Authors: Egloff AM, Rothstein ME, Seethala R, Siegfried JM, Grandis JR, Stabile LP
Clin. Cancer Res., 2009;15(21):6529-40.
Species: Human
Sample Type: Cell Culture Supernates

Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer.
Authors: Han SW, Oh DY, Im SA, Park SR, Lee KW, Song HS, Lee NS, Lee KH, Choi IS, Lee MH, Kim MA, Kim WH, Bang YJ, Kim TY
Br. J. Cancer, 2009;100(2):298-304.
Species: Human
Sample Type: Serum

Validation of HB-EGF and amphiregulin as targets for human cancer therapy.
Authors: Yotsumoto F, Yagi H, Suzuki SO, Oki E, Tsujioka H, Hachisuga T, Sonoda K, Kawarabayashi T, Mekada E, Miyamoto S
Biochem. Biophys. Res. Commun., 2007;365(3):555-61.
Species: Human
Sample Type: Cell Culture Supernates

The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events.
Authors: Moss ML, Bomar M, Liu Q, Sage H, Dempsey P, Lenhart PM, Gillispie PA, Stoeck A, Wildeboer D, Bartsch JW, Palmisano R, Zhou P
J. Biol. Chem., 2007;282(49):35712-21.
Species: Human
Sample Type: Cell Culture Supernates

Alteration of the serum levels of the epidermal growth factor receptor and its ligands in patients with non-small cell lung cancer and head and neck carcinoma.
Authors: Lemos-Gonzalez Y, Rodriguez-Berrocal FJ, Cordero OJ, Gomez C, Paez de la Cadena M
Br. J. Cancer, 2007;96(10):1569-78.
Species: Human
Sample Type: Serum

Expression and role of EGFR ligands induced in airway cells by PM2.5 and its components.
Authors: Rumelhard M, Ramgolam K, Hamel R, Marano F, Baeza-Squiban A
Eur. Respir. J., 2007;30(6):1064-73.
Species: Human
Sample Type: Cell Culture Supernates

Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells.
Authors: Eckstein N, Servan K, Girard L, Cai D, von Jonquieres G, Jaehde U, Kassack MU, Gazdar AF, Minna JD, Royer HD
J. Biol. Chem., 2007;283(2):739-50.
Species: Human
Sample Type: Cell Culture Supernates

Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer.
Authors: Zhou BB, Peyton M, He B, Liu C, Girard L, Caudler E, Lo Y, Baribaud F, Mikami I, Reguart N, Yang G, Li Y, Yao W, Vaddi K, Gazdar AF, Friedman SM, Jablons DM, Newton RC, Fridman JS, Minna JD, Scherle PA
Cancer Cell, 2006;10(1):39-50.
Species: Human
Sample Type: Cell Culture Supernates

The response of human epithelial cells to TNF involves an inducible autocrine cascade.
Authors: Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK
Cell, 2006;124(6):1225-39.
Species: Human
Sample Type: Cell Culture Supernates

Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli.
Authors: Baginski TK, Dabbagh K, Satjawatcharaphong C, Swinney DC
Am. J. Respir. Cell Mol. Biol., 2006;35(2):165-74.
Species: Human
Sample Type: Cell Culture Supernates

Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy.
Authors: Miyamoto S, Hirata M, Yamazaki A, Kageyama T, Hasuwa H, Mizushima H, Tanaka Y, Yagi H, Sonoda K, Kai M, Kanoh H, Nakano H, Mekada E
Cancer Res., 2004;64(16):5720-7.
Species: Human
Sample Type: Ascites

Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK.
Authors: Kansra S, Johnson JL
Mol. Biol. Cell, 2004;15(9):4299-309.
Species: Human
Sample Type: Cell Culture Supernates