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Human MICB DuoSet ELISA, 15 Plate (1 KT)

货号: DY1599 基本售价: 10120.7 元 规格: 1 KIT

产品信息

概述
货号DY1599
别名
MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I polypeptide-related sequence B; MICB; MIC-B; PERB11.2MHC class I-like molecule PERB11.2-IMX; stress inducible class I homolog
全称MHC Class I-related Protein B
反应种属Human
目标/特异性Please see the product datasheet
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs4277 (Human);
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids.
Authors: Giannattasio A, Weil S, Kloess S, Ansari N, Stelzer E, Cerwenka A, Steinle A, Koehl U, Koch J
BMC Cancer, 2015;15(0):351.
Species: Human
Sample Type: Cell Culture Supernates

Umbilical cord blood plasma contains soluble NKG2D ligands that mediate loss of natural killer cell function and cytotoxicity.
Authors: Cox S, Laza-Briviesca R, Pearson H, Soria B, Gibson D, Gomez S, Madrigal J, Saudemont A
Eur J Immunol, 2015;45(8):2324-34.

Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells.
Authors: Zingoni A, Cecere F, Vulpis E, Fionda C, Molfetta R, Soriani A, Petrucci M, Ricciardi M, Fuerst D, Amendola M, Mytilineos J, Cerboni C, Paolini R, Cippitelli M, Santoni A
J Immunol, 2015;195(2):736-48.
Species: Human
Sample Type: Cell Culture Supernates

Nonblocking Monoclonal Antibody Targeting Soluble MIC Revamps Endogenous Innate and Adaptive Antitumor Responses and Eliminates Primary and Metastatic Tumors.
Authors: Lu S, Zhang J, Liu D, Li G, Staveley-OCarroll K, Li Z, Wu J
Clin Cancer Res, 2015;21(21):4819-30.
Species: Mouse
Sample Type: Serum

Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fas- and NK cell-mediated cell death.
Authors: Yamanegi K, Yamane J, Kobayashi K
Int. J. Oncol., 2012;41(1):83-91.
Species: Human
Sample Type: Cell Culture Supernates

Combinatorial Cytotoxicity of Gemcitabine and Cytokine-activated Killer Cells in Hepatocellular Carcinoma via the NKG2D-MICA/B System.
Authors: Morisaki T, Onishi H, Koya N
Anticancer Res., 2011;31(7):2505-10.
Species: Human
Sample Type: Cell Culture Supernates

The role of activation-induced cell death in the higher onset of spontaneous apoptosis of NK cell subsets in patients with metastatic epithelial cancer.
Authors: Stanzer S, Janesch B, Resel M, Augustin T, Samonigg H, Bauernhofer T
Cell. Immunol., 2010;261(2):99-104.
Species: Human
Sample Type: Serum

The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia.
Authors: Nuckel H, Switala M, Sellmann L, Horn PA, Durig J, Duhrsen U, Kuppers R, Grosse-Wilde H, Rebmann V
Leukemia, 2010;24(6):1152-9.
Species: Human
Sample Type: Plasma

Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation.
Authors: Ho VT, Vanneman M, Kim H, Sasada T, Kang YJ, Pasek M, Cutler C, Koreth J, Alyea E, Sarantopoulos S, Antin JH, Ritz J, Canning C, Kutok J, Mihm MC, Dranoff G, Soiffer R
Proc. Natl. Acad. Sci. U.S.A., 2009;106(37):15825-30.
Species: Human
Sample Type: Cell Culture Supernates

Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells.
Authors: Cerboni C, Ardolino M, Santoni A, Zingoni A
Blood, 2009;113(13):2955-64.
Species: Human
Sample Type: Cell Culture Supernates

Obstructing shedding of the immunostimulatory MHC class I chain-related gene B prevents tumor formation.
Authors: Wu JD, Atteridge CL, Wang X, Seya T, Plymate SR
Clin. Cancer Res., 2009;15(2):632-40.
Species: Mouse
Sample Type: Cell Lysates

Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: role of nitric oxide.
Authors: Siemens DR, Hu N, Sheikhi AK, Chung E, Frederiksen LJ, Pross H, Graham CH
Cancer Res., 2008;68(12):4746-53.
Species: Human
Sample Type: Cell Culture Supernates

背景MHC class I chain-related genes MICA and MICB are transmembrane glycoproteins that function as ligands for human NKG2D. The two proteins are highly related, sharing 85% amino acid identity, but are also polymorphic. Recognition of MICA or MICB by NKG2D results in the activation of NK cell cytolytic activity and/or cytokine production. MICA/B are minimally expressed on normal cells, but are frequently expressed on or shed from epithelial tumors and can be induced by bacterial and viral infections. MICA and MICB recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.
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