| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Mesenchymal stem cells are efficiently transduced with adenoviruses bearing type 35-derived fibers and the transduced cells with the IL-28A gene produces cytotoxicity to lung carcinoma cells co-cultured.
Authors: Suzuki T, Kawamura K, Li Q, Okamoto S, Tada Y, Tatsumi K, Shimada H, Hiroshima K, Yamaguchi N, Tagawa M
BMC Cancer, 2014;14(0):713.
Species: Human
Sample Type: Cell Culture Supernates
Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells.
Authors: Dolganiuc A, Kodys K, Marshall C, Saha B, Zhang S, Bala S, Szabo G
PLoS ONE, 2012;7(10):e44915.
Species: Human
Sample Type: Serum
Hepatitis C virus NS3/4A protease blocks IL-28 production.
Eur J Immunol, 2012;42(9):2374-82.
Species: Human
Sample Type: Cell Culture Supernates
Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta.
Authors: Bierne H, Travier L, Mahlakoiv T, Tailleux L, Subtil A, Lebreton A, Paliwal A, Gicquel B, Staeheli P, Lecuit M, Cossart P
PLoS ONE, 2012;7(6):e39080.
Species: Human
Sample Type: Cell Culture Supernates
Adenoviruses-mediated transduction of human oesophageal carcinoma cells with the interferon-lambda genes produced anti-tumour effects.
Authors: Li Q, Kawamura K, Okamoto S, Fujie H, Numasaki M, Namba M, Nagata M, Shimada H, Kobayashi H, Tagawa M
Br. J. Cancer, 2011;105(9):1302-12.
Species: Human
Sample Type: Cell Culture Supernates
Alpha/beta interferon (IFN-alpha/beta)-independent induction of IFN-lambda1 (interleukin-29) in response to Hantaan virus infection.
Authors: Stoltz M, Klingstrom J
J. Virol., 2010;84(18):9140-8.
Species: Human
Sample Type: Cell Culture Supernates
Inhibition of dynamin-dependent endocytosis interferes with type III IFN expression in bacteria-infected human monocyte-derived DCs.
Authors: Pietila TE, Latvala S, Osterlund P, Julkunen I
J. Leukoc. Biol., 2010;88(4):665-74.
Species: Human
Sample Type: Cell Culture Supernates
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| 背景 | Human/mouse IL-28A (IFN-lambda 2), IL-28B (IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity). These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1). Mouse IL-28 shares 61%, 62%, and 52% aa identity with human IL-28A, IL-28B, and IL-29, respectively. |
