| 货号 | DY1578 |
| 别名 | CCL14; CCL14a; HCC1; HCC-1 |
| 反应种属 | Human |
| 目标/特异性 | Please see the product datasheet |
| 供应商 | R&D Systems |
| 检测类型 | Solid Phase Sandwich ELISA |
| Entrez Gene IDs | 6358 (Human); |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Recognition versus adaptive up-regulation and degradation of CC chemokines by the chemokine decoy receptor D6 are determined by their N-terminal sequence. | |
| 背景 | CCL14, is a member of the chemokine superfamily of ligands. In-depth genome analysis has determined that there is no mouse ortholog for human CCL14. Two alternatively spliced isoforms of CCL14, CCL14a/HCC-1 and CCL14b/HHC-3, have been identified. The CCL14a/HCC-1 isoform is a 93 amino acid (aa) precursor peptide with a predicted molecular weight of 10 kDa, while the CCL14b/HCC-3 isoform contains an additional 17 aa insertion and has a predicted molecular weight of 12 kDa. CCL14a/HCC-1 is cleaved into a 74 aa secreted bioactive peptide by Plasmin or u-Plasminogen Activator/Urokinase. CCL14a/HCC-1 binds and activates CCR1, CCR3, and CCR5; it also binds the non-signaling chemokine decoy receptors DARC and D6. CCL14a/HCC-1 is widely expressed in normal tissues including spleen, liver, skeletal and heart muscle, gut, and bone marrow, and it circulates at high concentrations in the plasma. CCL14a/HCC-1 induces the chemotaxis of T lymphocytes, monocytes, and eosinophils. It also exhibits anti-HIV activities by causing CCR5, a key mediator of HIV entry, internalization and intracellular sequestration. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |