Human Neprilysin DuoSet ELISA, 15 Plate (1 KT)【科瑞奥博】

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Human Neprilysin DuoSet ELISA, 15 Plate (1 KT)

货号： DY1182 基本售价： 10120.7 元规格： 1 KIT

产品信息

概述
货号	DY1182
别名	Atriopeptidase; CALLA; CALLAmembrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); CD10 antigen; CD10; CD10); CD10membrane metallo-endopeptidase variant 1; Common acute lymphocytic leukemia antigen; DKFZp686O16152; EC 3.4.24; EC 3.4.24.11; Enkephalinase; EPN; Leu-19; membrane metallo-endopeptidase variant 2; membrane metallo-endopeptidase; MGC126681; MGC126707; MME; NEPmembrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA; Neprilysin; Neutral Endopeptidase 24.11; Neutral endopeptidase; NKH1; SFE; Skin fibroblast elastase
反应种属	Human
目标/特异性	Please see the product datasheet

性能
供应商	R&D Systems
检测类型	Solid Phase Sandwich ELISA
Entrez Gene IDs	4311 (Human); 17380 (Mouse); 24590 (Rat);
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. CD10 enhances metastasis of colorectal cancer by abrogating the anti-tumoural effect of methionine-enkephalin in the liver. Authors: Kuniyasu H, Luo Y, Fujii K, Sasahira T, Moriwaka Y, Tatsumoto N, Sasaki T, Yamashita Y, Ohmori H Gut, 2010;59(3):348-56. Species: Human Sample Type: Tissue Homogenates Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme. Authors: Miners JS, van Helmond Z, Kehoe PG, Love S Brain Pathol., 2010;20(4):794-802. Species: Human Sample Type: Tissue Homogenates Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid. Authors: Miners JS, Verbeek MM, Rikkert MO, Kehoe PG, Love S J. Neurosci. Methods, 2008;167(2):229-36. Species: Human Sample Type: Tissue Homogenates
背景	The neprilysin (NEP) family of zinc metallopeptidases includes neprilysin, endothelin-converting enzyme-2 (ECE-2), PEX, damage induced neuronal endopeptidase (DINE), Kell and several neprilysin-like proteins. Neprilysin is expressed at the cell surface of a variety of cell types. Enzymatically, neprilysin functions both as an endopeptidase with a thermolysin-like specificity and as a dipeptidylcarboxypeptidase. Neprilysin has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide. Neprilysin has also been identified as the common acute lymphoblastic leukemia antigen (CALLA), and to be expressed on the surface of lymphocytes in some disease states. These and other observations have resulted in considerable clinical interest in neprilysin as a potential target for analgesics and antihypertensive drugs. Neprilysin is also a major degrading enzyme of amyloid-beta peptide (A-beta) in the brain, indicating that down-regulation of neprilysin activity, which could be caused by aging, can contribute to the development of Alzheimers disease by promoting A-beta accumulation.
运输条件	Blue Ice
存放说明	4℃