| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Regulation of RAGE ectodomain shedding and its role in cell function
Authors: A Braley, T Kwak, J Jules, E Harja, R Landgraf, BI Hudson
J Biol Chem, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates
Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology.
Authors: Moser B, Janik S, Schiefer A, Mullauer L, Bekos C, Scharrer A, Mildner M, Renyi-Vamos F, Klepetko W, Ankersmit H
PLoS ONE, 2014;9(4):e94118.
Species: Human
Sample Type: Serum
Circulating endothelial progenitor cells and large artery structure and function in young subjects with uncomplicated type 1 diabetes.
Authors: Palombo C, Kozakova M, Morizzo C, Gnesi L, Barsotti M, Spontoni P, Massart F, Salvi P, Balbarini A, Saggese G, Di Stefano R, Federico G
Cardiovasc Diabetol, 2011;10(0):88.
Species: Human
Sample Type: Plasma
Circulating soluble receptor for advanced glycation end-product levels are decreased in patients with calcific aortic valve stenosis.
Authors: Basta G, Corciu AI, Vianello A, Del Turco S, Foffa I, Navarra T, Chiappino D, Berti S, Mazzone A
Atherosclerosis, 2010;210(2):614-8.
Species: Human
Sample Type: Plasma
High plasma levels of the soluble receptor for advanced glycation endproducts in patients with symptomatic carotid atherosclerosis.
Authors: Basta G, Castagnini M, Del Turco S, Epistolato MC, Righini P, Sangiorgi GM, De Caterina R, Tanganelli P
Eur. J. Clin. Invest., 2009;39(12):1065-72.
Species: Human
Sample Type: Plasma
Suspension microarrays for the identification of the response patterns in hyperinflammatory diseases.
Authors: Hsu HY, Wittemann S, Schneider EM, Weiss M, Joos TO
Med Eng Phys, 2008;30(8):976-83.
Species: Human
Sample Type: Plasma
Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury.
Authors: Determann RM, Wolthuis EK, Choi G, Bresser P, Bernard A, Lutter R, Schultz MJ
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;294(2):L344-50.
Species: Human
Sample Type: BALF
Distribution of the receptor for advanced glycation end products in the human male reproductive tract: prevalence in men with diabetes mellitus.
Authors: Mallidis C, Agbaje I, Rogers D, Glenn J, McCullough S, Atkinson AB, Steger K, Stitt A, McClure N
Hum. Reprod., 2007;22(8):2169-77.
Species: Human
Sample Type: seminal plasma
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| 背景 | RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration. |
