| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon.
Authors: Knoop, K A, McDonald, K G, McCrate, S, McDole, J R, Newberry, R D
Mucosal Immunol, 2015;8(1):198-210.
Species: Human
Sample Type: Cell Lysate
Activation of brain endothelial cells by interleukin-1 is regulated by the extracellular matrix after acute brain injury.
Authors: Summers L, Kangwantas K, Rodriguez-Grande B, Denes A, Penny J, Kielty C, Pinteaux E
Mol Cell Neurosci, 2013;57(0):93-103.
Species: Rat
Sample Type: Cell Lysate
Ras oncoproteins transfer from melanoma cells to T cells and modulate their effector functions.
Authors: Vernitsky H, Rechavi O, Rainy N, Besser M, Nagar M, Schachter J, Lerenthal Y, Ehrlich M, Kloog Y, Goldstein I
J Immunol, 2012;189(9):4361-70.
Species: Human
Sample Type: Cell Lysates
CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infection.
Authors: Gouwy M, Struyf S, Berghmans N, Vanormelingen C, Schols D, Van Damme J
Eur. J. Immunol., 2011;41(4):963-73.
Species: Human
Sample Type: Cell Lysates
Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse.
Authors: Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ
J. Cell. Biochem., 2010;109(6):1185-91.
Species: Mouse
Sample Type: Tissue Homogenates
Soluble forms of VEGF receptor-1 and -2 promote vascular maturation via mural cell recruitment.
Authors: Lorquet S, Berndt S, Blacher S, Gengoux E, Peulen O, Maquoi E, Noel A, Foidart JM, Munaut C, Pequeux C
FASEB J., 2010;24(10):3782-95.
Species: Human
Sample Type: Cell Lysates
Protein-disulfide isomerase-associated 3 (Pdia3) mediates the membrane response to 1,25-dihydroxyvitamin D3 in osteoblasts.
Authors: Chen J, Olivares-Navarrete R, Wang Y
J. Biol. Chem., 2010;285(47):37041-50.
Species: Mouse
Sample Type: Cell Lysates
Demonstration of the equivalent pharmacokinetic/pharmacodynamic dosing strategy in a multiple-dose study of gefitinib.
Authors: Wang S, Zhou Q, Gallo JM
Mol. Cancer Ther., 2009;8(6):1438-47.
Species: Human
Sample Type: Tissue Homogenates
Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4.
Authors: Struyf S, Noppen S, Loos T, Mortier A, Gouwy M, Verbeke H, Huskens D, Luangsay S, Parmentier M, Geboes K, Schols D, Van Damme J, Proost P
J. Immunol., 2009;182(1):666-74.
Species: Human
Sample Type: Cell Lysates
Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation.
Authors: Loos T, Mortier A, Gouwy M, Ronsse I, Put W, Lenaerts JP, Van Damme J, Proost P
Blood, 2008;112(7):2648-56.
Species: Hamster
Sample Type: Cell Lysates
Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events.
Authors: Gouwy M, Struyf S, Noppen S, Schutyser E, Springael JY, Parmentier M, Proost P, Van Damme J
Mol. Pharmacol., 2008;74(2):485-95.
Species: Hamster
Sample Type: Cell Lysates
Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling.
Authors: Muselet-Charlier C, Roque T, Boncoeur E, Chadelat K, Clement A, Jacquot J, Tabary O
Biochem. Biophys. Res. Commun., 2007;357(2):402-7.
Species: Human
Sample Type: Cell Lysates
In vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist; correlations between desensitization and tolerance.
Authors: Aguila B, Coulbault L, Boulouard M, Leveille F, Davis A, Toth G, Borsodi A, Balboni G, Salvadori S, Jauzac P, Allouche S
Br. J. Pharmacol., 2007;152(8):1312-24.
Species: Human
Sample Type: Cell Lysates
Intracellular HIV-Tat expression induces IL-10 synthesis by the CREB-1 transcription factor through Ser133 phosphorylation and its regulation by the ERK1/2 MAPK in human monocytic cells.
Authors: Gee K, Angel JB, Ma W, Mishra S, Gajanayaka N, Parato K, Kumar A
J. Biol. Chem., 2006;281(42):31647-58.
Species: Human
Sample Type: Cell Lysates
Low dose leflunomide activates PI3K/Akt signalling in erythroleukemia cells and reduces apoptosis induced by anticancer agents.
Authors: Leger DY, Liagre B, Beneytout JL
Apoptosis, 2006;11(10):1747-60.
Species: Human
Sample Type: Cell Lysates
Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes.
Authors: Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B
Cytokine, 2005;31(5):335-48.
Species: Human
Sample Type: Cell Lysates
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| 背景 | ERK1 and ERK2 (also known as MAPK3 and MAPK1) are 44 and 42 kDa Ser/Thr kinases, respectively. They are part of the Ras-Raf-ERK signal transduction cascade often found downstream of growth factor receptor activation. ERK1 and ERK2 were initially isolated and cloned as kinases activated in response to insulin and NGF. They are expressed in most, if not all, mammalian tissues. Dual threonine and tyrosine phosphorylation activate both ERKs, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2. ERK5, also known as Big Mitogen-activated Protein Kinase 1 (BMK1) and MAPK7, is activated by several mechanisms, including receptor tyrosine kinases, G protein-coupled receptors, and osmotic stress. Like ERK1 and ERK2, ERK5 contains the conserved Thr-Glu-Tyr activation motif in its activation loop. Unlike these ERKs, however, ERK5 contains a unique C-terminal domain that regulates its activation and nuclear translocation. |
