Human R-Spondin 4 DuoSet ELISA, 5 Plate (1 KT)
货号：
DY4575-05 基本售价：
4667.7 元 规格：
1 KIT
产品信息
概述| 货号 | DY4575-05 |
| 别名 | C20orf182; chromosome 20 open reading frame 182; Cristin 4; CRISTIN4; dJ824F16.3; FLJ16018; hRspo4; Roof plate-specific spondin-4; RSPO4; RSpondin 4; R-Spondin 4; R-spondin family, member 4; R-spondin-4 |
全称 | Roof Plate-specific Spondin 4 | | 反应种属 | Human |
| 目标/特异性 | Please see the product datasheet |
性能| 供应商 | R&D Systems |
| 检测类型 | Solid Phase Sandwich ELISA |
| Entrez Gene IDs | 343637 (Human); 228770 (Mouse); |
| 背景 | R-Spondin 4 (RSPO4, roof plate-specific spondin 4), also called cysteine-rich and single thrombospondin domain containing-4 (Cristin 4), is an ~33 kDa secreted heparin-binding protein that shares ~35% amino acid (aa) identity with three other R-Spondin family members. All are positive modulators of Wnt/beta-Catenin signaling, but vary in activity. R-Spondins regulate Wnt/beta-Catenin by competing with the Wnt antagonist DKK-1 for binding to the Wnt co-receptors LRP-6 and Kremen, reducing their DKK-1-mediated internalization. Like other R-spondins, human R-Spondin 4 (228 aa) contains a signal sequence (aa 1-19), two adjacent cysteine-rich furin-like domains (aa 85-128) with one potential tyrosine phosphorylation site (aa 114), followed by a thrombospondin (TSP-1) motif (aa 137-197) and a region rich in basic residues (aa 199-228). Mature human R-Spondin 4 shares 81%, 81%, 84%, 84% and 86% aa identity with mouse, rat, equine, canine and bovine R-Spondin 4, respectively. Of two potential isoforms, one lacks the TSP-1 domain, while another terminates at aa 224. Each R-Spondin has a distinct expression pattern. In the mouse, R-Spondin 4 mRNA is found during development of limb bud mesenchyme, nail beds, heart and teeth. In humans, mutations of R-Spondin 4 have been found to cause anonychia, a condition in which fingernails and toenails are absent. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
