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Mouse IL-21 DuoSet ELISA, 5 Plate (1 KT)

货号: DY594-05 基本售价: 3882.5 元 规格: 1 KIT

产品信息

概述
货号DY594-05
别名
IL21; IL-21; IL-21Za11interleukin-21; interleukin 21; interleukin-21 isoform
全称Interleukin 21
反应种属Mouse
目标/特异性Please see the product datasheet
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs59067 (Human); 60505 (Mouse); 365769 (Rat); 442935 (Canine); 100344172 (Rabbit);
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

ER? in CD4+ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity
J Immunol, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells.
Authors: Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S, Hoshino T, Yagita H, Ohteki T, Iwata M
Mucosal Immunol, 2014;7(4):786-801.
Species: Mouse
Sample Type: cell supernates

CXCR5(+) T helper cells mediate protective immunity against tuberculosis.
Authors: Slight S, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko B, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart T, Randall T, Khader S
J Clin Invest, 2013;123(2):712-26.
Species: Mouse
Sample Type: Cell Culture Supernates

The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
Authors: El-Behi M, Ciric B, Dai H
Nat. Immunol., 2011;12(6):568-75.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-21 Promotes Skin Recruitment of CD4+ Cells and Drives IFN-{gamma}-Dependent Epidermal Hyperplasia.
Authors: Sarra M, Caruso R, Cupi ML, Monteleone I, Stolfi C, Campione E, Diluvio L, Mazzotta A, Botti E, Chimenti S, Costanzo A, MacDonald TT, Pallone F, Monteleone G
J. Immunol., 2011;186(9):5435-42.
Species: Mouse
Sample Type: Tissue Homogenates

Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins.
Authors: Takeuchi H, Yokota A, Ohoka Y, Kagechika H, Kato C, Song SY, Iwata M
J. Immunol., 2010;185(9):5289-99.
Species: Mouse
Sample Type: Cell Culture Supernates

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
Authors: Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Hasler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
J. Exp. Med., 2010;207(8):1617-24.
Species: Mouse
Sample Type: Cell Culture Supernates

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
Authors: Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M
J. Exp. Med., 2009;206(1):69-78.
Species: Mouse
Sample Type: Cell Culture Supernates

The AP-1 transcription factor Batf controls T(H)17 differentiation.
Authors: Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM
Nature, 2009;460(7253):405-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Local IL-21 promotes the therapeutic activity of effector T cells by decreasing regulatory T cells within the tumor microenvironment.
Authors: Kim-Schulze S, Kim HS, Fan Q, Kim DW, Kaufman HL
Mol. Ther., 2009;17(2):380-8.
Species: Mouse
Sample Type: Cell Culture Supernates

A fundamental role for interleukin-21 in the generation of T follicular helper cells.
Authors: Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C
Immunity, 2008;29(1):127-37.
Species: Mouse
Sample Type: Cell Culture Supernates

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.
Authors: Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S
Nat. Immunol., 2008;9(7):769-76.
Species: Mouse
Sample Type: Cell Culture Supernates

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
Authors: Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P
Nat. Genet., 2007;39(3):329-37.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production.
Authors: Coquet JM, Kyparissoudis K, Pellicci DG, Besra G, Berzins SP, Smyth MJ, Godfrey DI
J. Immunol., 2007;178(5):2827-34.
Species: Mouse
Sample Type: Cell Culture Supernates

Interleukin-21 activates cytotoxic T lymphocytes and natural killer cells to generate antitumor response in mouse renal cell carcinoma.
Authors: Kumano M, Hara I, Furukawa J, Oniki S, Nagai H, Miyake H, Fujisawa M
J. Urol., 2007;178(4):1504-9.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.
Authors: Wei L, Laurence A, Elias KM, OShea JJ
J. Biol. Chem., 2007;282(48):34605-10.
Species: Mouse
Sample Type: Cell Culture Supernates

背景IL-21 (Interleukin-21) is member of the family of cytokines that utilize the common gamma chain as a receptor subunit. This subunit is also a component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex of the common gamma chain and the IL-21-specific IL-21 R. IL-21 supports Tfh cell development, immunoglobulin affinity maturation, plasma cell differentiation, B cell memory responses, and the migration of dendritic cells to draining lymph nodes. It costimulates the activation, proliferation, and survival of CD8+ T cells and NKT cells and promotes Th17 cell polarization. It blocks the generation of regulatory T cells and their suppressive effects on CD4+ T cells. In addition, IL-21 suppresses cutaneous hypersensitivity reactions by limiting allergen-specific IgE production and mast cell degranulation.
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