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Mouse IFN-gamma DuoSet ELISA, 5 Plate (1 KT)

货号: DY485-05 基本售价: 3882.5 元 规格: 1 KIT

产品信息

概述
货号DY485-05
别名
IFG; IFI; IFNG; IFNgamma; IFN-gamma; Immune interferon; interferon gamma; interferon, gamma
全称Interferon gamma
反应种属Mouse
目标/特异性Please see the product datasheet
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs3458 (Human); 15978 (Mouse); 25712 (Rat); 396991 (Porcine); 281237 (Bovine); 403801 (Canine); 493965 (Feline);
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Proinflammatory M1 macrophages inhibit RANKL-induced osteoclastogenesis
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF-?B Activation in Neutrophils
J Immunol, 2016;196(5):2319-26.
Species: Mouse
Sample Type: BALF

Myelin Oligodendrocyte Glycoprotein induces incomplete tolerance of CD4(+) T cells specific for both a myelin and a neuronal self antigen in mice
Authors: Liliana E Lucca
Eur J Immunol, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors
EMBO Mol Med, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

Dendritic Cell-Like Cells Accumulate in Regenerating Murine Skeletal Muscle after Injury and Boost Adaptive Immune Responses Only upon a Microbial Challenge
PLoS ONE, 2016;11(5):e0155870.
Species: Mouse
Sample Type: Cell Culture Supernates

Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection
J Immunol, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis
PLoS ONE, 2016;11(5):e0154630.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression
Authors: JL Reyes, MR Fernando, F Lopes, G Leung, NL Mancini, CE Matisz, A Wang, DM McKay
PLoS Pathog, 2016;12(4):e1005481.
Species: Mouse
Sample Type: Cell Culture Supernates

ER? in CD4+ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity
J Immunol, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

Impact of Histone H1 on the Progression of Allergic Rhinitis and Its Suppression by Neutralizing Antibody in Mice
Authors: T Nakano, R Kamei, T Fujimura, Y Takaoka, A Hori, CY Lai, KC Chiang, Y Shimada, N Ohmori, T Goto, K Ono, CL Chen, S Goto, S Kawamoto
PLoS ONE, 2016;11(4):e0153630.
Species: Mouse
Sample Type: Cell Culture Supernates

Repeated Activation of Lung Invariant NKT Cells Results in Chronic Obstructive Pulmonary Disease-Like Symptoms.
Authors: Tsao C, Tsao P, Chen Y, Chuang Y
PLoS ONE, 2016;11(1):e0147710.
Species: Mouse
Sample Type: BALF

Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis
Authors: Pan Su
J Immunol, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

Coadministration of a Plasmid Encoding HIV-1 Gag Enhances the Efficacy of Cancer DNA Vaccines
Mol Ther, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

Cannabinoid receptor 2 modulates susceptibility to experimental cerebral malaria through a CCL17-dependent mechanism
J Biol Chem, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

Poly-N-acetyl glucosamine production by Staphylococcus epidermidis cells increases their in vivo pro-inflammatory effect
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Type: Peritoneal Exudates

The circadian clock regulates inflammatory arthritis
FASEB J, 2016;0(0):.
Species: Mouse
Sample Type: Serum

AAV8-Mediated Angiotensin-Converting Enzyme 2 Gene Delivery Prevents Experimental Autoimmune Uveitis by Regulating MAPK, NF-?B and STAT3 Pathways
Sci Rep, 2016;6(0):31912.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-22 dampens the T cell response in experimental malaria
Authors: Julie Sellau
Sci Rep, 2016;6(0):28058.
Species: Mouse
Sample Type: Cell Culture Supernates

Interleukin-27 Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response
Authors: Gustavo F S Quirino
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Type: Tissue Homogenates

Eriobotrya japonica Water Extract Characterization: An Inducer of Interferon-Gamma Production Mainly by the JAK-STAT Pathway
Authors: Khalid Z Matalka
Molecules, 2016;21(6):.
Species: Mouse
Sample Type: Cell Culture Supernates

TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.
Authors: Na B, Kim H, Piragyte I, Oh H, Kwon M, Akber U, Lee H, Park D, Song W, Park Z, Im S, Rho M, Hyun Y, Kim M, Jun C
J Cell Biol, 2015;209(1):143-62.
Species: Mouse
Sample Type: Cell Culture Supernates

Innate immunity drives the initiation of a murine model of primary biliary cirrhosis.
Authors: Chang C, Chen Y, Zhang W, Leung P, Gershwin M, Chuang Y
PLoS ONE, 2015;10(3):e0121320.
Species: Mouse
Sample Type: Serum

NK cells require IL-28R for optimal in vivo activity.
Authors: Souza-Fonseca-Guimaraes F, Young A, Mittal D, Martinet L, Bruedigam C, Takeda K, Andoniou C, Degli-Esposti M, Hill G, Smyth M
Proc Natl Acad Sci U S A, 2015;112(18):E2376-84.
Species: Mouse
Sample Type: Cell culture supernatant

Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice.
Authors: Li Y, Chen H, Bannick N, Henry M, Holm A, Metwali A, Urban J, Rothman P, Weiner G, Blazar B, Elliott D, Ince M
J Immunol, 2015;194(3):1011-20.
Species: Mouse
Sample Type: Cell Culture Supernates

Th1-Like ICOS+ Foxp3+ Treg Cells Preferentially Express CXCR3 and Home to beta-Islets during Pre-Diabetes in BDC2.5 NOD Mice.
Authors: Kornete M, Mason E, Girouard J, Lafferty E, Qureshi S, Piccirillo C
PLoS ONE, 2015;10(5):e0126311.
Species: Mouse
Sample Type: Homogenized Tissue

B cells modulate systemic responses to Pneumocystis murina lung infection and protect on-demand hematopoiesis via T cell-independent innate mechanisms when type I interferon signaling is absent.
Authors: Hoyt T, Dobrinen E, Kochetkova I, Meissner N
Infect Immun, 2015;83(2):743-58.
Species: Mouse
Sample Type: Serum

Hydroxypropyl-beta-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen.
Authors: Onishi M, Ozasa K, Kobiyama K, Ohata K, Kitano M, Taniguchi K, Homma T, Kobayashi M, Sato A, Katakai Y, Yasutomi Y, Wijaya E, Igarashi Y, Nakatsu N, Ise W, Inoue T, Yamada H, Vandenbon A, Standley D, Kurosaki T, Coban C, Aoshi T, Kuroda E, Ishii K
J Immunol, 2015;194(6):2673-82.
Species: Mouse
Sample Type: Cell Culture Supernates

DCIR maintains bone homeostasis by regulating IFN-gamma production in T cells.
Authors: Maruhashi T, Kaifu T, Yabe R, Seno A, Chung S, Fujikado N, Iwakura Y
J Immunol, 2015;194(12):5681-91.
Species: Mouse
Sample Type: Tissue Homogenates

Limited Contribution of IL-36 versus IL-1 and TNF Pathways in Host Response to Mycobacterial Infection.
Authors: Segueni N, Vigne S, Palmer G, Bourigault M, Olleros M, Vesin D, Garcia I, Ryffel B, Quesniaux V, Gabay C
PLoS ONE, 2015;10(5):e0126058.
Species: Mouse
Sample Type: Homogenized Tissue

Superior Suppressive Capacity of Skin Tregs Compared with Lung Tregs in a Model of Epicutaneous Priming.
Authors: Mahapatra S, Albrecht M, Baru A, Sparwasser T, Herrick C, Dittrich A
J Invest Dermatol, 2015;135(10):2418-26.
Species: Mouse
Sample Type: Cell Culture Supernates

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.
Authors: Brown A, Murphy A, Lalor S, Leech J, OKeeffe K, Mac Aogain M, OHalloran D, Lacey K, Tavakol M, Hearnden C, Fitzgerald-Hughes D, Humphreys H, Fennell J, van Wamel W, Foster T, Geoghegan J, Lavelle E, Rogers T, McLoughlin R
PLoS Pathog, 2015;11(11):e1005226.
Species: Mouse
Sample Type: Cell Culture Supernatesperitoneal exudate

Differential Immunometabolic Phenotype in Th1 and Th2 Dominant Mouse Strains in Response to High-Fat Feeding.
Authors: Jovicic N, Jeftic I, Jovanovic I, Radosavljevic G, Arsenijevic N, Lukic M, Pejnovic N
PLoS ONE, 2015;10(7):e0134089.
Species: Mouse
Sample Type: Tissue Homogenates

CD252 regulates mast cell mediated, CD1d-restricted NKT-cell activation in mice.
Authors: Gonzalez Roldan N, Orinska Z, Ewers H, Bulfone-Paus S
Eur J Immunol, 2015;46(2):432-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.
Authors: Gillgrass A, Chew M, Krneta T, Ashkar A
BMC Cancer, 2015;15(0):293.
Species: Mouse
Sample Type: Cell Culture Supernates

Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells.
Authors: Fontinha D, Lopes F, Marques S, Simas J
PLoS ONE, 2015;10(11):e0142540.
Species: Mouse
Sample Type: Cell Culture Supernates

Effects of High-Intensity Swimming on Lung Inflammation and Oxidative Stress in a Murine Model of DEP-Induced Injury.
Authors: Avila L, Bruggemann T, Bobinski F, da Silva M, Oliveira R, Martins D, Mazzardo-Martins L, Duarte M, de Souza L, Dafre A, Vieira R, Santos A, Bonorino K, Hizume Kunzler D
PLoS ONE, 2015;10(9):e0137273.
Species: Mouse
Sample Type: Tissue Homogenates

Proinflammatory effects of interferon gamma in mouse adenovirus 1 myocarditis.
Authors: McCarthy M, Procario M, Twisselmann N, Wilkinson J, Archambeau A, Michele D, Day S, Weinberg J
J Virol, 2015;89(1):468-79.
Species: Mouse
Sample Type: Tissue Homogenates

Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge.
Authors: Monin L, Griffiths K, Slight S, Lin Y, Rangel-Moreno J, Khader S
Mucosal Immunol, 2015;8(5):1099-109.
Species: Mouse
Sample Type: Cell Culture Supernates

High IFN-gamma and low SLPI mark severe asthma in mice and humans.
Authors: Raundhal M, Morse C, Khare A, Oriss T, Milosevic J, Trudeau J, Huff R, Pilewski J, Holguin F, Kolls J, Wenzel S, Ray P, Ray A
J Clin Invest, 2015;125(8):3037-50.
Species: Mouse
Sample Type: Tissue Homogenates

Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function.
Authors: Sahakian E, Powers J, Chen J, Deng S, Cheng F, Distler A, Woods D, Rock-Klotz J, Sodre A, Youn J, Woan K, Villagra A, Gabrilovich D, Sotomayor E, Pinilla-Ibarz J
Mol Immunol, 2015;63(2):579-85.
Species: Mouse
Sample Type: Cell Culture Supernates

A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis.
Authors: Bernard N, Finlay C, Tannahill G, Cassidy J, ONeill L, Mills K
Mucosal Immunol, 2015;8(5):982-92.
Species: Mouse
Sample Type: Tissue Homogenates

Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Authors: Ataide M, Andrade W, Zamboni D, Wang D, Souza M, Franklin B, Elian S, Martins F, Pereira D, Reed G, Fitzgerald K, Golenbock D, Gazzinelli R
PLoS Pathog, 2014;10(1):e1003885.
Species: Mouse
Sample Type: Blood

MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection.
Authors: Berod L, Stuve P, Swallow M, Arnold-Schrauf C, Kruse F, Gentilini M, Freitag J, Holzmann B, Sparwasser T
Eur J Immunol, 2014;44(5):1399-409.
Species: Mouse
Sample Type: Serum

Pulmonary immune responses to 2009 pandemic influenza A (H1N1) virus in mice.
Authors: Lv J, Wang D, Hua Y, Pei S, Wang J, Hu W, Wang X, Jia N, Jiang Q
BMC Infect Dis, 2014;14(0):197.
Species: Mouse
Sample Type: Tissue Homogenates

A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation.
Authors: Csoka B, Koscso B, Toro G, Kokai E, Virag L, Nemeth Z, Pacher P, Bai P, Hasko G
Diabetes, 2014;63(3):850-66.
Species: Mouse
Sample Type: Plasma

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.
Authors: Hams, Emily, Armstrong, Michelle, Barlow, Jillian, Saunders, Sean P, Schwartz, Christia, Cooke, Gordon, Fahy, Ruairi J, Crotty, Thomas B, Hirani, Nikhil, Flynn, Robin J, Voehringer, David, McKenzie, Andrew N, Donnelly, Seamas C, Fallon, Padraic
Proc Natl Acad Sci U S A, 2014;111(1):367-72.
Species: Mouse
Sample Type: Tissue Homogenates

Sm10.3, a member of the micro-exon gene 4 (MEG-4) family, induces erythrocyte agglutination in vitro and partially protects vaccinated mice against Schistosoma mansoni infection.
Authors: Martins V, Morais S, Pinheiro C, Assis N, Figueiredo B, Ricci N, Alves-Silva J, Caliari M, Oliveira S
PLoS Negl Trop Dis, 2014;8(3):e2750.
Species: Mouse
Sample Type: Cell Culture Supernates

Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35.
Authors: Aparicio-Siegmund S, Moll J, Lokau J, Grusdat M, Schroder J, Plohn S, Rose-John S, Grotzinger J, Lang P, Scheller J, Garbers C
PLoS ONE, 2014;9(9):e107990.
Species: Mouse
Sample Type: cell supernates

Role of the aryl hydrocarbon receptor in the immune response profile and development of pathology during Plasmodium berghei Anka infection.
Authors: Brant F, Miranda A, Esper L, Rodrigues D, Kangussu L, Bonaventura D, Soriani F, Pinho V, Souza D, Rachid M, Weiss L, Tanowitz H, Teixeira M, Teixeira A, Machado F
Infect Immun, 2014;82(8):3127-40.
Species: Mouse
Sample Type: Tissue Homogenates

Role of OGR1 in myeloid-derived cells in prostate cancer.
Authors: Yan, L, Singh, L S, Zhang, L, Xu, Y
Oncogene, 2014;33(2):157-64.
Species: Mouse
Sample Type: Cell Culture Supernates

Signaling via tumor necrosis factor receptor 1 but not Toll-like receptor 2 contributes significantly to hydrosalpinx development following Chlamydia muridarum infection.
Authors: Dong X, Liu Y, Chang X, Lei L, Zhong G
Infect Immun, 2014;82(5):1833-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Fingolimod attenuates splenocyte-induced demyelination in cerebellar slice cultures.
Authors: Pritchard A, Mir A, Dev K
PLoS ONE, 2014;9(6):e99444.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1.
Authors: Heinemann C, Heink S, Petermann F, Vasanthakumar A, Rothhammer V, Doorduijn E, Mitsdoerffer M, Sie C, Prazeres da Costa O, Buch T, Hemmer B, Oukka M, Kallies A, Korn T
Nat Commun, 2014;5(0):3770.
Species: Mouse
Sample Type: Cell Culture Supernates

IFN-gamma-producing and IL-17-producing gammadelta T cells differentiate at distinct developmental stages in murine fetal thymus.
Authors: Shibata K, Yamada H, Nakamura M, Hatano S, Katsuragi Y, Kominami R, Yoshikai Y
J Immunol, 2014;192(5):2210-8.
Species: Mouse
Sample Type: Cell Culture Supernates

Epithelial NF-kappaB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling.
Authors: Tully J, Hoffman S, Lahue K, Nolin J, Anathy V, Lundblad L, Daphtary N, Aliyeva M, Black K, Dixon A, Poynter M, Irvin C, Janssen-Heininger Y
J Immunol, 2013;191(12):5811-21.
Species: Mouse
Sample Type: Tissue Homogenates

Toll-like receptor 6 senses Mycobacterium avium and is required for efficient control of mycobacterial infection.
Authors: Marinho F, de Paula R, Mendes A, de Almeida L, Gomes M, Carvalho N, Oliveira F, Caliari M, Oliveira S
Eur J Immunol, 2013;43(9):2373-85.
Species: Mouse
Sample Type: Cell Culture Supernates

Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation.
Authors: Horton J, Hudak K, Chung E, White A, Scroggins B, Burkeen J, Citrin D
Stem Cells, 2013;31(10):2231-41.
Species: Mouse
Sample Type: Tissue Homogenates

CXCR5(+) T helper cells mediate protective immunity against tuberculosis.
Authors: Slight S, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko B, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart T, Randall T, Khader S
J Clin Invest, 2013;123(2):712-26.
Species: Mouse
Sample Type: Cell Culture Supernates

Bifidobacterium longum alleviates dextran sulfate sodium-induced colitis by suppressing IL-17A response: involvement of intestinal epithelial costimulatory molecules.
Authors: Miyauchi, Eiji, Ogita, Tasuku, Miyamoto, Junki, Kawamoto, Seiji, Morita, Hidetosh, Ohno, Hiroshi, Suzuki, Takuya, Tanabe, Soichi
PLoS ONE, 2013;8(11):e79735.
Species: Mouse
Sample Type: cell culture supernate

Vaccination using recombinants influenza and adenoviruses encoding amastigote surface protein-2 are highly effective on protection against Trypanosoma cruzi infection.
Authors: Barbosa R, Filho B, Dos Santos L, Junior P, Marques P, Pereira R, Cara D, Bruna-Romero O, Rodrigues M, Gazzinelli R, Machado A
PLoS ONE, 2013;8(4):e61795.
Species: Mouse
Sample Type: Cell Culture Supernates

Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor.
Authors: van Voorhis, Michael, Knopp, Samantha, Julliard, Walker, Fechner, John H, Zhang, Xiaoji, Schauer, James J, Mezrich, Joshua D
PLoS ONE, 2013;8(12):e82545.
Species: Mouse
Sample Type: Cell Culture Supernates

Subcomponent vaccine based on CTA1-DD adjuvant with incorporated UreB class II peptides stimulates protective Helicobacter pylori immunity.
Authors: Nedrud J, Bagheri N, Schon K, Xin W, Bergroth H, Eliasson D, Lycke N
PLoS ONE, 2013;8(12):e83321.
Species: Mouse
Sample Type: Cell Culture Supernates

Rac2-deficiency leads to exacerbated and protracted colitis in response to Citrobacter rodentium infection.
Authors: Fattouh R, Guo C, Lam G, Gareau M, Ngan B, Glogauer M, Muise A, Brumell J
PLoS ONE, 2013;8(4):e61629.
Species: Mouse
Sample Type: Cell culture supernatant

Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T cells.
Authors: Zhang T, Sentman C
J Immunol, 2013;190(5):2455-63.
Species: Mouse
Sample Type: cell culture supernate

Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model.
Authors: Everitt, Aaron R, Clare, Simon, McDonald, Jacqueli, Kane, Leanne, Harcourt, Katherin, Ahras, Malika, Lall, Amar, Hale, Christin, Rodgers, Angela, Young, Douglas, Haque, Ashraful, Billker, Oliver, Tregoning, John S, Dougan, Gordon, Kellam, Paul
PLoS ONE, 2013;8(11):e80723.
Species: Mouse
Sample Type: BALF

Effects of Lactobacillus kefiranofaciens M1 isolated from kefir grains on germ-free mice.
Authors: Chen Y, Chen M
PLoS ONE, 2013;8(11):e78789.
Species: Mouse
Sample Type: Cell Culture Supernates

Alveolar Macrophages Play a Key Role in Cockroach-Induced Allergic Inflammation via TNF-alpha Pathway.
Authors: Kim J, Sohn J, Choi J, Lee J, Hong C, Lee J, Park J
PLoS ONE, 2012;7(10):e47971.
Species: Mouse
Sample Type: Tissue Homogenates

Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor.
J. Exp. Med., 2012;209(10):1753-67, S1.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-10 mediated regulation of liver inflammation during acute murine cytomegalovirus infection.
Authors: Gaddi, Pamela J, Crane, Meredith, Kamanaka, Masahito, Flavell, Richard, Yap, George S, Salazar-Mather, Thais P
PLoS ONE, 2012;7(8):e42850.
Species: Mouse
Sample Type: Serum

Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12.
Authors: Paulissen G, El Hour M, Rocks N, Gueders M, Bureau F, Foidart J, Lopez-Otin C, Noel A, Cataldo D
J Immunol, 2012;189(8):4135-43.
Species: Mouse
Sample Type: Tissue Homogenates

Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection.
Authors: Veliz Rodriguez T, Moalli F, Polentarutti N, Paroni M, Bonavita E, Anselmo A, Nebuloni M, Mantero S, Jaillon S, Bragonzi A, Mantovani A, Riva F, Garlanda C
Infect. Immun., 2012;80(1):100-9.
Species: Mouse
Sample Type: Serum

TLR9 and MyD88 are crucial for the development of protective immunity to malaria.
Authors: Gowda NM, Wu X, Gowda DC
J. Immunol., 2012;188(10):5073-85.
Species: Mouse
Sample Type: Cell Culture Supernates

Immune Modulation Mediated by Cryptococcal Laccase Promotes Pulmonary Growth and Brain Dissemination of Virulent Cryptococcus neoformans in Mice.
Authors: Qiu Y, Davis M, Dayrit J, Hadd Z, Meister D, Osterholzer J, Williamson P, Olszewski M
PLoS ONE, 2012;7(10):e47853.
Species: Mouse
Sample Type: Cell Culture Supernates

Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response.
Authors: Oh J, Lee R, Yu J, Ko J, Lee H, Ko A, Roddy G, Prockop D
Mol Ther, 2012;20(11):2143-52.
Species: Mouse
Sample Type: Tissue Homogenates

Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection.
Authors: Teijaro JR, Walsh KB, Cahalan S, Fremgen DM, Roberts E, Scott F, Martinborough E, Peach R, Oldstone MB, Rosen H
Cell, 2011;146(6):980-91.
Species: Mouse
Sample Type: BALF

Api6/AIM/Sp{alpha}/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma.
Authors: Li Y, Qu P, Wu L, Li B, Du H, Yan C
Cancer Res., 2011;71(16):5488-99.
Species: Mouse
Sample Type: Serum

CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition.
Authors: Barber DL, Mayer-Barber KD, Feng CG
J. Immunol., 2011;186(3):1598-607.
Species: Mouse
Sample Type: BALF

Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via alphavbeta1 integrin.
Authors: Kang S, Okuno T, Takegahara N, Takamatsu H, Nojima S, Kimura T, Yoshida Y, Ito D, Ohmae S, You DJ, Toyofuku T, Jang MH, Kumanogoh A
J. Immunol., 2011;188(3):1108-16.
Species: Mouse
Sample Type: Cell Culture Supernates

Phosphoinositide 3-kinase gamma plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice.
Authors: Russo RC, Garcia CC, Barcelos LS, Rachid MA, Guabiraba R, Roffe E, Souza AL, Sousa LP, Mirolo M, Doni A, Cassali GD, Pinho V, Locati M, Teixeira MM
J. Leukoc. Biol., 2011;89(2):269-82.
Species: Mouse
Sample Type: Tissue Homogenates

The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in Chronic Lung Infection Caused by Pseudomonas aeruginosa.
Authors: Moalli F, Paroni M, Veliz Rodriguez T, Riva F, Polentarutti N, Bottazzi B, Valentino S, Mantero S, Nebuloni M, Mantovani A, Bragonzi A, Garlanda C
J. Immunol., 2011;186(9):5425-34.
Species: Mouse
Sample Type: Tissue Homogenates

Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein.
Authors: Le Goffic R, Leymarie O, Chevalier C, Rebours E, Da Costa B, Vidic J, Descamps D, Sallenave JM, Rauch M, Samson M, Delmas B
PLoS Pathog., 2011;7(8):e1002202.
Species: Mouse
Sample Type: BALF

A critical role for C5L2 in the pathogenesis of experimental allergic asthma.
Authors: Zhang X, Schmudde I, Laumonnier Y, Pandey MK, Clark JR, Konig P, Gerard NP, Gerard C, Wills-Karp M, Kohl J
J. Immunol., 2010;185(11):6741-52.
Species: Mouse
Sample Type: Cell Culture Supernates

Mucosal delivery of human papillomavirus pseudovirus-encapsidated plasmids improves the potency of DNA vaccination.
Authors: Graham BS, Kines RC, Corbett KS, Nicewonger J, Roberts JN, Schiller JT, Buck CB
Mucosal Immunol, 2010;3(5):475-86.
Species: Mouse
Sample Type: BALF

Alpha-Galactosylceramide-induced airway eosinophilia is mediated through the activation of NKT cells.
Authors: Chuang YH, Wang TC, Jen HY, Yu AL, Chiang BL
J. Immunol., 2010;186(8):4687-92.
Species: Mouse
Sample Type: BALF

Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5.
Authors: Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S, Sitaraman SV, Knight R, Ley RE, Gewirtz AT
Science, 2010;328(5975):228-31.
Species: Mouse
Sample Type: Cell Culture Supernates

Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity.
Authors: Sellge G, Magalhaes JG, Konradt C, Fritz JH, Salgado-Pabon W, Eberl G, Bandeira A, Di Santo JP, Sansonetti PJ, Phalipon A
J. Immunol., 2010;184(4):2076-85.
Species: Mouse
Sample Type: Cell Culture Supernates

The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection.
Authors: Steinberg C, Eisenacher K, Gross O, Reindl W, Schmitz F, Ruland J, Krug A
Eur. J. Immunol., 2009;39(4):1007-18.
Species: Mouse
Sample Type: Serum

A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARgamma-mediated suppression of toll-like receptor 4.
Authors: Reynolds CM, Draper E, Keogh B, Rahman A, Moloney AP, Mills KH, Loscher CE, Roche HM
J. Nutr., 2009;139(12):2351-7.
Species: Mouse
Sample Type: Serum

Expression of bioactive single-chain murine IL-12 in transgenic plants.
Authors: Liu J, Dolan MC, Reidy M, Cramer CL
J. Interferon Cytokine Res., 2009;28(0):381-92.
Species: Mouse
Sample Type: Cell Culture Supernates

Effects of umbelliferone in a murine model of allergic airway inflammation.
Authors: Vasconcelos JF, Teixeira MM, Barbosa-Filho JM, Agra MF, Nunes XP, Giulietti AM, Ribeiro-Dos-Santos R, Soares MB
Eur. J. Pharmacol., 2009;609(1):126-31.
Species: Mouse
Sample Type: BALF

Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice.
Authors: Wells SM, Buford MC, Migliaccio CT, Holian A
Am. J. Respir. Cell Mol. Biol., 2009;40(2):179-88.
Species: Mouse
Sample Type: BALF

CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1.
Authors: Han Y, Guo Q, Zhang M, Chen Z, Cao X
J. Immunol., 2009;182(1):111-20.
Species: Mouse
Sample Type: Cell Culture Supernates

Mucosal immunity in mice induced by orally administered transgenic rice.
Authors: Zhang X, Yuan Z, Duan Q, Zhu H, Yu H, Wang Q
Vaccine, 2009;27(10):1596-600.
Species: Mouse
Sample Type: Cell Culture Supernates

A chlamydial type III-secreted effector protein (Tarp) is predominantly recognized by antibodies from humans infected with Chlamydia trachomatis and induces protective immunity against upper genital tract pathologies in mice.
Authors: Wang J, Chen L, Chen F, Zhang X, Zhang Y, Baseman J, Perdue S, Yeh IT, Shain R, Holland M, Bailey R, Mabey D, Yu P, Zhong G
Vaccine, 2009;27(22):2967-80.
Species: Mouse
Sample Type: Cell Culture Supernates

Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection.
Authors: Schaefer M, Reiling N, Fessler C, Stephani J, Taniuchi I, Hatam F, Yildirim AO, Fehrenbach H, Walter K, Ruland J, Wagner H, Ehlers S, Sparwasser T
J. Immunol., 2008;180(10):6836-45.
Species: Mouse
Sample Type: Cell Culture Supernates

Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection.
Authors: Bozza S, Zelante T, Moretti S, Bonifazi P, DeLuca A, DAngelo C, Giovannini G, Garlanda C, Boon L, Bistoni F, Puccetti P, Mantovani A, Romani L
J. Immunol., 2008;180(6):4022-31.
Species: Mouse
Sample Type: Cell Culture Supernates

Amelioration of experimental autoimmune encephalomyelitis in IL-4Ralpha-/- mice implicates compensatory up-regulation of Th2-type cytokines.
Authors: Gaupp S, Cannella B, Raine CS
Am. J. Pathol., 2008;173(1):119-29.
Species: Mouse
Sample Type: Cell Culture Supernates

Amelioration of delayed-type hypersensitivity responses by IL-27 administration.
Authors: Miyazaki Y, Shimanoe Y, Wang S, Yoshida H
Biochem. Biophys. Res. Commun., 2008;373(3):397-402.
Species: Mouse
Sample Type: Cell Culture Supernates

Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection.
Authors: Macedo GC, Magnani DM, Carvalho NB, Bruna-Romero O, Gazzinelli RT, Oliveira SC
J. Immunol., 2008;180(2):1080-7.
Species: Mouse
Sample Type: Cell Culture Supernates

CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production.
Authors: Wong KL, Lew FC, MacAry PA, Kemeny DM
Eur. J. Immunol., 2008;38(8):2251-62.
Species: Mouse
Sample Type: Cell Culture Supernates

Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis.
Authors: Kaya Z, Goser S, Buss SJ, Leuschner F, Ottl R, Li J, Volkers M, Zittrich S, Pfitzer G, Rose NR, Katus HA
Circulation, 2008;118(20):2063-72.
Species: Mouse
Sample Type: Cell Culture Supernates

Streptococcus equi antigens adsorbed onto surface modified poly-epsilon-caprolactone microspheres induce humoral and cellular specific immune responses.
Authors: Florindo HF, Pandit S, Goncalves LM, Alpar HO, Almeida AJ
Vaccine, 2008;26(33):4168-77.
Species: Mouse
Sample Type: Cell Culture Supernates

Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17.
Authors: Schulz SM, Kohler G, Schutze N, Knauer J, Straubinger RK, Chackerian AA, Witte E, Wolk K, Sabat R, Iwakura Y, Holscher C, Muller U, Kastelein RA, Alber G
J. Immunol., 2008;181(11):7891-901.
Species: Mouse
Sample Type: Serum

Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemia.
Authors: Lembo A, Pelletier M, Iyer R, Timko M, Dudda JC, West TE, Wilson CB, Hajjar AM, Skerrett SJ
J. Immunol., 2008;180(11):7574-81.
Species: Mouse
Sample Type: Tissue Homogenates

Surfactant protein D alters allergic lung responses in mice and human subjects.
Authors: Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME
J. Allergy Clin. Immunol., 2008;121(5):1140-1147.e2.
Species: Mouse
Sample Type: BALF

Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function.
Authors: Csoka B, Himer L, Selmeczy Z, Vizi ES, Pacher P, Ledent C, Deitch EA, Spolarics Z, Nemeth ZH, Hasko G
FASEB J., 2008;22(10):3491-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation.
Authors: Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, Hildeman DA, Belkaid Y, Chougnet C
J. Immunol., 2008;181(3):1835-48.
Species: Mouse
Sample Type: Cell Culture Supernates

Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.
Authors: Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ
Immunity, 2007;26(4):445-59.
Species: Mouse
Sample Type: Cell Culture Supernates

Chimeric NKG2D receptor-bearing T cells as immunotherapy for ovarian cancer.
Authors: Barber A, Zhang T, DeMars LR, Conejo-Garcia J, Roby KF, Sentman CL
Cancer Res., 2007;67(10):5003-8.
Species: Mouse
Sample Type: Cell Culture Supernates

Lactoferrin enhanced efficacy of the BCG vaccine to generate host protective responses against challenge with virulent Mycobacterium tuberculosis.
Authors: Hwang SA, Wilk KM, Budnicka M, Olsen M, Bangale YA, Hunter RL, Kruzel ML, Actor JK
Vaccine, 2007;25(37):6730-43.
Species: Mouse
Sample Type: Cell Culture Supernates

An alternative pathway of NF-kappaB activation results in maturation and T cell priming activity of dendritic cells overexpressing a mutated IkappaBalpha.
Authors: Moore F, Buonocore S, Aksoy E, Ouled-Haddou N, Goriely S, Lazarova E, Paulart F, Heirman C, Vaeremans E, Thielemans K, Goldman M, Flamand V
J. Immunol., 2007;178(3):1301-11.
Species: Mouse
Sample Type: Cell Culture Supernates

Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis.
Authors: Ephrem A, Chamat S, Miquel C, Fisson S, Mouthon L, Caligiuri G, Delignat S, Elluru S, Bayry J, Lacroix-Desmazes S, Cohen JL, Salomon BL, Kazatchkine MD, Kaveri SV, Misra N
Blood, 2007;111(2):715-22.
Species: Mouse
Sample Type: Cell Culture Supernates

Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice.
Authors: Robertson SA, Care AS, Skinner RJ
Biol. Reprod., 2007;76(5):738-48.
Species: Mouse
Sample Type: Serum

Differing effects of clarithromycin and azithromycin on cytokine production by murine dendritic cells.
Authors: Sugiyama K, Shirai R, Mukae H, Ishimoto H, Nagata T, Sakamoto N, Ishii H, Nakayama S, Yanagihara K, Mizuta Y, Kohno S
Clin. Exp. Immunol., 2007;147(3):540-6.
Species: Mouse
Sample Type: Cell Culture Supernates

Deletion of TLR5 results in spontaneous colitis in mice.
Authors: Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT
J. Clin. Invest., 2007;117(12):3909-21.
Species: Mouse
Sample Type: Serum

CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.
Authors: Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J
Neurobiol. Dis., 2007;29(2):336-53.
Species: Mouse
Sample Type: Cell Culture Supernates

NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis.
Authors: Walsh KB, Lanier LL, Lane TE
J. Virol., 2007;82(6):3031-44.
Species: Mouse
Sample Type: Tissue Homogenates

The differential effect of Eriobotrya japonica hydrophilic leaf extract on cytokines production and modulation.
Authors: Matalka KZ, Ali D, Khawad AE, Qadan F
Cytokine, 2007;40(3):235-40.
Species: Mouse
Sample Type: Serum

Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15.
Authors: Bulanova E, Budagian V, Duitman E, Orinska Z, Krause H, Ruckert R, Reiling N, Bulfone-Paus S
J. Biol. Chem., 2007;282(18):13167-79.
Species: Mouse
Sample Type: Cell Culture Supernates

Mycobacterium tuberculosis antigens specifically modulate CCR2 and MCP-1/CCL2 on lymphoid cells from human pulmonary hilar lymph nodes.
Authors: Arias MA, Jaramillo G, Lopez YP, Mejia N, Mejia C, Pantoja AE, Shattock RJ, Garcia LF, Griffin GE
J. Immunol., 2007;179(12):8381-91.
Species: Human
Sample Type: Cell Culture Supernates

CXCR3-dependent recruitment of antigen-specific T lymphocytes to the liver during murine cytomegalovirus infection.
Authors: Hokeness KL, Deweerd ES, Munks MW, Lewis CA, Gladue RP, Salazar-Mather TP
J. Virol., 2007;81(3):1241-50.
Species: Mouse
Sample Type: Cell Culture Supernates

Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae.
Authors: Rodriguez N, Wantia N, Fend F, Durr S, Wagner H, Miethke T
Eur. J. Immunol., 2006;36(5):1145-55.
Species: Mouse
Sample Type: Tissue Homogenates

Transgenic expression of a CD83-immunoglobulin fusion protein impairs the development of immune-competent CD4-positive T cells.
Authors: Luthje K, Cramer SO, Ehrlich S, Veit A, Steeg C, Fleischer B, Bonin A, Breloer M
Eur. J. Immunol., 2006;36(8):2035-45.
Species: Mouse
Sample Type: Cell Culture Supernates

The effects of dehydroepiandrosterone (DHEA) on in vitro spleen cell proliferation and cytokine production.
Authors: Powell JM, Sonnenfeld G
J. Interferon Cytokine Res., 2006;26(1):34-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice.
Authors: Robertson SA, Skinner RJ, Care AS
J. Immunol., 2006;177(7):4888-96.
Species: Mouse
Sample Type: Serum

Mucosal administration of CpG oligodeoxynucleotide elicits strong CC and CXC chemokine responses in the vagina and serves as a potent Th1-tilting adjuvant for recombinant gD2 protein vaccination against genital herpes.
Authors: Tengvall S, Lundqvist A, Eisenberg RJ, Cohen GH, Harandi AM
J. Virol., 2006;80(11):5283-91.
Species: Mouse
Sample Type: Cell Culture Supernates

Leukemia inhibitory factor is linked to regulatory transplantation tolerance.
Authors: Metcalfe SM, Watson TJ, Shurey S, Adams E, Green CJ
Transplantation, 2005;79(6):726-30.
Species: Mouse
Sample Type: Cell Culture Supernates

Dendritic cells and NK cells stimulate bystander T cell activation in response to TLR agonists through secretion of IFN-alpha beta and IFN-gamma.
Authors: Kamath AT, Sheasby CE, Tough DF
J. Immunol., 2005;174(2):767-76.
Species: Mouse
Sample Type: Cell Culture Supernates

Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance.
Authors: Metcalfe SM, Muthukumarana PA, Thompson HL, Haendel MA, Lyons GE
FEBS Lett., 2005;579(3):609-14.
Species: Mouse
Sample Type: Cell Culture Supernates

MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.
Authors: Delale T, Paquin A, Asselin-Paturel C, Dalod M, Brizard G, Bates EE, Kastner P, Chan S, Akira S, Vicari A, Biron CA, Trinchieri G, Briere F
J. Immunol., 2005;175(10):6723-32.
Species: Mouse
Sample Type: Serum

Subcellular fractions of Brucella ovis distinctively induce the production of interleukin-2, interleukin-4, and interferon-gamma in mice.
Authors: Salas-Tellez E, Nunez del Arco A, Tenorio V, Diaz-Aparicio E, de la Garza M, Suarez-Guemes F
Can. J. Vet. Res., 2005;69(1):53-7.
Species: Mouse
Sample Type: Cell Culture Supernates

Attenuation of primary nonfunction for syngeneic islet graft using sodium 4-phenylbutyrate.
Authors: Fu SH, Chen ST, Hsu BR
Transplant. Proc., 2005;37(4):1830-1.
Species: Mouse
Sample Type: Cell Culture Supernates

Immunosuppressive effects of CCL17 on pulmonary antifungal responses during pulmonary invasive aspergillosis.
Authors: Carpenter KJ, Hogaboam CM
Infect. Immun., 2005;73(11):7198-207.
Species: Mouse
Sample Type: Tissue Homogenates

Comparative immunomodulatory properties of a chitosan-MDP adjuvant combination following intranasal or intramuscular immunisation.
Authors: Moschos SA, Bramwell VW, Somavarapu S, Alpar HO
Vaccine, 2005;23(16):1923-30.
Species: Mouse
Sample Type: Cell Culture Supernates

Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions.
Authors: Aviles H, Belay T, Vance M, Sun B, Sonnenfeld G
J. Appl. Physiol., 2004;97(4):1437-44.
Species: Mouse
Sample Type: Cell Culture Supernates

Long-term control of Mycobacterium bovis BCG infection in the absence of Toll-like receptors (TLRs): investigation of TLR2-, TLR6-, or TLR2-TLR4-deficient mice.
Authors: Nicolle D, Fremond C, Pichon X, Bouchot A, Maillet I, Ryffel B, Quesniaux VJ
Infect. Immun., 2004;72(12):6994-7004.
Species: Mouse
Sample Type: Cell Lysates

Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88.
Authors: Fremond CM, Yeremeev V, Nicolle DM, Jacobs M, Quesniaux VF, Ryffel B
J. Clin. Invest., 2004;114(12):1790-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection.
Authors: Torres D, Barrier M, Bihl F, Quesniaux VJ, Maillet I, Akira S, Ryffel B, Erard F
Infect. Immun., 2004;72(4):2131-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Comparison of immunogenicities of recombinant Plasmodium vivax merozoite surface protein 1 19- and 42-kiloDalton fragments expressed in Escherichia coli.
Authors: Sachdeva S, Ahmad G, Malhotra P, Mukherjee P, Chauhan VS
Infect. Immun., 2004;72(10):5775-82.
Species: Mouse
Sample Type: Cell Culture Supernates

Transcutaneous immunization with cholera toxin B subunit adjuvant suppresses IgE antibody responses via selective induction of Th1 immune responses.
Authors: Anjuere F, George-Chandy A, Audant F, Rousseau D, Holmgren J, Czerkinsky C
J. Immunol., 2003;170(3):1586-92.
Species: Mouse
Sample Type: Cell Culture Supernates

Intracellular thiols contribute to Th2 function via a positive role in IL-4 production.
Authors: Monick MM, Samavati L, Butler NS, Mohning M, Powers LS, Yarovinsky T, Spitz DR, Hunninghake GW
J. Immunol., 2003;171(10):5107-15.
Species: Mouse
Sample Type: Cell Culture Supernates

背景IFN-gamma (Interferon-gamma) is the prototype proinflammatory cytokine and is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. IFN-gamma dimers signal through a receptor complex of two IFN-gamma R1 and two IFN-gamma R2 subunits.
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