Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria.
Authors: Todd D, Gulledge T, Britton E, Oberhofer M, Leyte-Lugo M, Moody A, Shymanovich T, Grubbs L, Juzumaite M, Graf T, Oberlies N, Faeth S, Laster S, Cech N
PLoS ONE, 2015;10(5):e0124276.
Species: Mouse
Sample Type: Cell culture supernatant

C1q Modulates the Response to TLR7 Stimulation by Pristane-Primed Macrophages: Implications for Pristane-Induced Lupus.
Authors: Carlucci F, Ishaque A, Ling G, Szajna M, Sandison A, Donatien P, Cook H, Botto M
J Immunol, 2015;196(4):1488-94.
Species: Mouse
Sample Type: Serum

The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory.
Authors: Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Chatton B, Inoue K, Uchiyama T, Ishibashi K, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M, Ishii S
Nat Immunol, 2015;16(10):1034-43.
Species: Mouse
Sample Type: Cell Culture Supernates

A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis.
Authors: Bernard N, Finlay C, Tannahill G, Cassidy J, ONeill L, Mills K
Mucosal Immunol, 2015;8(5):982-92.
Species: Mouse
Sample Type: Tissue Homogenates

Lack of platelet-activating factor receptor protects mice against diet-induced adipose inflammation and insulin-resistance despite fat pad expansion.
Authors: Menezes-Garcia Z, Oliveira M, Lima R, Soriani F, Cisalpino D, Botion L, Teixeira M, Souza D, Ferreira A
Obesity (Silver Spring), 2014;22(3):663-72.
Species: Mouse
Sample Type: Tissue Homogenates

Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor.
Authors: Goncalves-de-Albuquerque C, Burth P, Silva A, de Moraes I, Oliveira F, Santelli R, Freire A, de Lima G, da Silva E, da Silva C, Morandi V, Bozza P, Younes-Ibrahim M, de Castro Faria Neto H, de Castro Faria M
Respir Res, 2014;15(0):93.
Species: Mouse
Sample Type: BALF

UVB-induced skin inflammation and cutaneous tissue injury is dependent on the MHC class I-like protein, CD1d.
Authors: Ryser S, Schuppli M, Gauthier B, Hernandez D, Roye O, Hohl D, German B, Holzwarth J, Moodycliffe A
J Invest Dermatol, 2014;134(1):192-202.
Species: Mouse
Sample Type: Tissue Homogenates

Syntaxin binding protein 1 is not required for allergic inflammation via IgE-mediated mast cell activation.
Authors: Wu Z, MacNeil A, Berman J, Lin T
PLoS ONE, 2013;8(3):e58560.
Species: Mouse
Sample Type: cell supernates

Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection.
Authors: Veliz Rodriguez T, Moalli F, Polentarutti N, Paroni M, Bonavita E, Anselmo A, Nebuloni M, Mantero S, Jaillon S, Bragonzi A, Mantovani A, Riva F, Garlanda C
Infect. Immun., 2012;80(1):100-9.
Species: Mouse
Sample Type: Serum

Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid.
Authors: van Neerven S, Regen T, Wolf D, Nemes A, Johann S, Beyer C, Hanisch UK, Mey J
J. Neurochem., 2010;114(5):1511-26.
Species: Mouse
Sample Type: Cell Culture Supernates

Mucosal delivery of human papillomavirus pseudovirus-encapsidated plasmids improves the potency of DNA vaccination.
Authors: Graham BS, Kines RC, Corbett KS, Nicewonger J, Roberts JN, Schiller JT, Buck CB
Mucosal Immunol, 2010;3(5):475-86.
Species: Mouse
Sample Type: BALF

Chorionic gonadotropin alleviates thioglycollate-induced peritonitis by affecting macrophage function.
Authors: Wan H, Coppens JM, van Helden-Meeuwsen CG, Leenen PJ, Van Rooijen N, Khan NA, Kiekens RC, Benner R, Versnel MA
J. Leukoc. Biol., 2009;86(2):361-70.
Species: Mouse
Sample Type: Peritoneal Lavage

CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process.
Authors: Wu Y, Li YY, Matsushima K, Baba T, Mukaida N
J. Immunol., 2008;181(9):6384-93.
Species: Mouse
Sample Type: Tissue Homogenates

Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection.
Authors: Macedo GC, Magnani DM, Carvalho NB, Bruna-Romero O, Gazzinelli RT, Oliveira SC
J. Immunol., 2008;180(2):1080-7.
Species: Mouse
Sample Type: Cell Culture Supernates

gammadeltaT cell-mediated regulation of chemokine producing macrophages during Listeria monocytogenes infection-induced inflammation.
Authors: Tramonti D, Rhodes K, Martin N, Dalton JE, Andrew E, Carding SR
J. Pathol., 2008;216(2):262-70.
Species: Mouse
Sample Type: Cell Culture Supernates

VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways.
Authors: Tiwari N, Wang CC, Brochetta C, Ke G, Vita F, Qi Z, Rivera J, Soranzo MR, Zabucchi G, Hong W, Blank U
Blood, 2008;111(7):3665-74.
Species: Mouse
Sample Type: Cell Culture Supernates

Dual effect of AMD3100, a CXCR4 antagonist, on bleomycin-induced lung inflammation.
Authors: Watanabe M, Matsuyama W, Shirahama Y, Mitsuyama H, Oonakahara K, Noma S, Higashimoto I, Osame M, Arimura K
J. Immunol., 2007;178(9):5888-98.
Species: Mouse
Sample Type: Tissue Homogenates

CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice.
Authors: Maeno T, Houghton AM, Quintero PA, Grumelli S, Owen CA, Shapiro SD
J. Immunol., 2007;178(12):8090-6.
Species: Mouse
Sample Type: BALF

Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.
Authors: Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ
Immunity, 2007;26(4):445-59.
Species: Mouse
Sample Type: Cell Culture Supernates

Mycobacterium tuberculosis antigens specifically modulate CCR2 and MCP-1/CCL2 on lymphoid cells from human pulmonary hilar lymph nodes.
Authors: Arias MA, Jaramillo G, Lopez YP, Mejia N, Mejia C, Pantoja AE, Shattock RJ, Garcia LF, Griffin GE
J. Immunol., 2007;179(12):8381-91.
Species: Human
Sample Type: Cell Culture Supernates

Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae.
Authors: Rodriguez N, Wantia N, Fend F, Durr S, Wagner H, Miethke T
Eur. J. Immunol., 2006;36(5):1145-55.
Species: Mouse
Sample Type: Tissue Homogenates

Mucosal administration of CpG oligodeoxynucleotide elicits strong CC and CXC chemokine responses in the vagina and serves as a potent Th1-tilting adjuvant for recombinant gD2 protein vaccination against genital herpes.
Authors: Tengvall S, Lundqvist A, Eisenberg RJ, Cohen GH, Harandi AM
J. Virol., 2006;80(11):5283-91.
Species: Mouse
Sample Type: Tissue Homogenates

Effects of dexamethazone on LPS-induced activationand migration of mouse dendritic cells revealed by a genome-wide transcriptional analysis.
Authors: Vizzardelli C, Pavelka N, Luchini A, Zanoni I, Bendickson L, Pelizzola M, Beretta O, Foti M, Granucci F, Nilsen-Hamilton M, Ricciardi-Castagnoli P
Eur. J. Immunol., 2006;36(6):1504-15.
Species: Mouse
Sample Type: Cell Culture Supernates

Evidence for the opposing roles of different gamma delta T cell subsets in macrophage homeostasis.
Authors: Tramonti D, Andrew EM, Rhodes K, Newton DJ, Carding SR
Eur. J. Immunol., 2006;36(7):1729-38.
Species: Mouse
Sample Type: Cell Culture Supernates

Immunosuppressive effects of CCL17 on pulmonary antifungal responses during pulmonary invasive aspergillosis.
Authors: Carpenter KJ, Hogaboam CM
Infect. Immun., 2005;73(11):7198-207.
Species: Mouse
Sample Type: Tissue Homogenates

MIP-1 gamma promotes receptor-activator-of-NF-kappa-B-ligand-induced osteoclast formation and survival.
Authors: Okamatsu Y, Battaglino R, Spate U, Stashenko P
J. Immunol., 2004;173(3):2084-90.
Species: Mouse
Sample Type: Whole Cells

Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages.
Authors: Punturieri A, Alviani RS, Polak T, Copper P, Sonstein J, Curtis JL
J. Immunol., 2004;173(2):1033-42.
Species: Mouse
Sample Type: Cell Culture Supernates

MIP-1 alpha (macrophage inflammatory protein 1 alpha) is a member of the CC or beta chemokine subfamily that was originally purified from the conditioned media of an LPS-stimulated murine macrophage cell line. MIP-1 alpha acts as a chemoattractant to a variety of cells including monocytes, T cells, B cells and eosinophils.

The two human MIP-1 alpha genes arise by duplication/mutation. They code for MIP-1 alpha isoforms CCL3/LD78a and CCL3L1/LD78b, which share 94% amino acid sequence homology. Whereas the human CCL3/LD78a is a single-copy gene, the human CCL3L1/LD78b gene copy number varies within the population. Human CCL3L1/LD78b binds and signals through chemokine receptors CCR1, CCR5. When compared to CCL3/LD78a, CCL3L1/LD78b has higher binding affinity to CCR5, which also functions as a coreceptor for HIV-1 entry. The copy number of CCL3L1 is one of several genetic determinants of HIV-1 susceptibility.