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Mouse IL-1 beta/IL-1F2 DuoSet ELISA, 5 Plate (1 KT)

货号: DY401-05 基本售价: 3882.5 元 规格: 1 KIT

产品信息

概述
货号DY401-05
别名
catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1b; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta
全称Interleukin 1 beta
反应种属Mouse
目标/特异性Please see the product datasheet
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig);
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF-?B Activation in Neutrophils
J Immunol, 2016;196(5):2319-26.
Species: Mouse
Sample Type: BALF

Hemocyanins Stimulate Innate Immunity by Inducing Different Temporal Patterns of Proinflammatory Cytokine Expression in Macrophages
J Immunol, 2016;196(11):4650-62.
Species: Mouse
Sample Type: Cell Culture Supernates

Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor
Sci Rep, 2016;6(0):26490.
Species: Mouse
Sample Type: Tissue Homogenates

Caspase-2 deficiency accelerates chemically induced liver cancer in mice
Cell Death Differ, 2016;0(0):.
Species: Mouse
Sample Type: Serum

HIF-1? Is an Essential Mediator of IFN-?-Dependent Immunity to Mycobacterium tuberculosis
J Immunol, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

The circadian clock regulates inflammatory arthritis
FASEB J, 2016;0(0):.
Species: Mouse
Sample Type: Serum

Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4
Authors: Kamlesh K Gupta
Biochem Biophys Res Commun, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells

Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection
Authors: Marieke Pingen
Immunity, 2016;44(6):1455-69.
Species: Mouse
Sample Type: Tissue Homogenates

Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype
Sci Rep, 2016;6(0):29712.
Species: Human
Sample Type: Cell Culture Supernates

Sphingosine-1-Phosphate Receptor 2 Regulates Proinflammatory Cytokine Production and Osteoclastogenesis
PLoS ONE, 2016;11(5):e0156303.
Species: Mouse
Sample Type: Cell Lysates

A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet
Authors: G Yang, HE Lee, JY Lee
Sci Rep, 2016;6(0):24399.
Species: Mouse
Sample Type: Cell Culture Supernates

Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation
J Clin Invest, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

Cell death is not essential for caspase-1-mediated interleukin-1? activation and secretion
Cell Death Differ, 2016;0(0):.

Infection-Mediated Priming of Phagocytes Protects against Lethal Secondary Aspergillus fumigatus Challenge
Authors: A Savers, O Rasid, M Parlato, M Brock, G Jouvion, B Ryffel, JM Cavaillon, G Eberl, O Ibrahim-Gr
PLoS ONE, 2016;11(4):e0153829.
Species: Mouse
Sample Type: tissue lysates

Effects of High-Intensity Swimming on Lung Inflammation and Oxidative Stress in a Murine Model of DEP-Induced Injury.
Authors: Avila L, Bruggemann T, Bobinski F, da Silva M, Oliveira R, Martins D, Mazzardo-Martins L, Duarte M, de Souza L, Dafre A, Vieira R, Santos A, Bonorino K, Hizume Kunzler D
PLoS ONE, 2015;10(9):e0137273.
Species: Mouse
Sample Type: Tissue Homogenates

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.
Authors: Brown A, Murphy A, Lalor S, Leech J, OKeeffe K, Mac Aogain M, OHalloran D, Lacey K, Tavakol M, Hearnden C, Fitzgerald-Hughes D, Humphreys H, Fennell J, van Wamel W, Foster T, Geoghegan J, Lavelle E, Rogers T, McLoughlin R
PLoS Pathog, 2015;11(11):e1005226.
Species: Mouse
Sample Type: Cell Culture Supernates

Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2.
Authors: Secor McVoy J, Oughli H, Oh U
J Neuroinflammation, 2015;12(0):27.
Species: Mouse
Sample Type: Cell Culture Supernates

The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
Authors: Douglas T, Champagne C, Morizot A, Lapointe J, Saleh M
J Immunol, 2015;195(5):2365-73.
Species: Mouse
Sample Type: Cell Culture Supernates

A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis.
Authors: Bernard N, Finlay C, Tannahill G, Cassidy J, ONeill L, Mills K
Mucosal Immunol, 2015;8(5):982-92.
Species: Mouse
Sample Type: Tissue Homgenates

Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling.
Authors: Wu Y, Wu Y, Mo S, Hsiao H, He Y, Lai M
J Immunol, 2015;195(6):2612-23.
Species: Mouse
Sample Type: Cell Culture Supernates

The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling.
Authors: Fleming B, Chandrasekaran P, Dillon L, Dalby E, Suresh R, Sarkar A, El-Sayed N, Mosser D
J Leukoc Biol, 2015;98(3):395-407.
Species: Mouse
Sample Type: Cell Culture Supernates

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Authors: Coll R, Robertson A, Chae J, Higgins S, Munoz-Planillo R, Inserra M, Vetter I, Dungan L, Monks B, Stutz A, Croker D, Butler M, Haneklaus M, Sutton C, Nunez G, Latz E, Kastner D, Mills K, Masters S, Schroder K, Cooper M, ONeill L
Nat Med, 2015;21(3):248-55.
Species: Mouse
Sample Type: Cell Culture Supernates

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.
Authors: Sester D, Sagulenko V, Thygesen S, Cridland J, Loi Y, Cridland S, Masters S, Genske U, Hornung V, Andoniou C, Sweet M, Degli-Esposti M, Schroder K, Stacey K
J Immunol, 2015;195(3):1233-41.
Species: Mouse
Sample Type: Cell Culture Supernates

An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1.
Authors: Shipkowski K, Taylor A, Thompson E, Glista-Baker E, Sayers B, Messenger Z, Bauer R, Jaspers I, Bonner J
PLoS ONE, 2015;10(6):e0128888.
Species: Mouse
Sample Type: BALF

Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production.
Authors: Kearney C, Cullen S, Tynan G, Henry C, Clancy D, Lavelle E, Martin S
Cell Death Differ, 2015;22(8):1313-27.
Species: Mouse
Sample Type: Cell Culture Supernates

Lack of platelet-activating factor receptor protects mice against diet-induced adipose inflammation and insulin-resistance despite fat pad expansion.
Authors: Menezes-Garcia Z, Oliveira M, Lima R, Soriani F, Cisalpino D, Botion L, Teixeira M, Souza D, Ferreira A
Obesity (Silver Spring), 2014;22(3):663-72.
Species: Mouse
Sample Type: Tissue Homogenates

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.
Authors: Dowling J, Becker C, Bourke N, Corr S, Connolly D, Quinn S, Pandolfi P, Mansell A, ONeill L
J Biol Chem, 2014;289(10):6429-37.
Species: Mouse
Sample Type: cell supernates

PPAR-gamma/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis.
Authors: Ferreira A, Sisti F, Sonego F, Wang S, Filgueiras L, Brandt S, Serezani A, Du H, Cunha F, Alves-Filho J, Serezani C
J Immunol, 2014;192(5):2357-65.
Species: Mouse
Sample Type: Serum

Role of IL-1β in experimental cystic fibrosis upon P. aeruginosa infection.
PLoS ONE, 2014;9(12):e114884.
Species: Mouse
Sample Type: Tissue Homogenates

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.
Authors: Hams, Emily, Armstrong, Michelle, Barlow, Jillian, Saunders, Sean P, Schwartz, Christia, Cooke, Gordon, Fahy, Ruairi J, Crotty, Thomas B, Hirani, Nikhil, Flynn, Robin J, Voehringer, David, McKenzie, Andrew N, Donnelly, Seamas C, Fallon, Padraic
Proc Natl Acad Sci U S A, 2014;111(1):367-72.
Species: Mouse
Sample Type: Tissue Homogenates

Role of the aryl hydrocarbon receptor in the immune response profile and development of pathology during Plasmodium berghei Anka infection.
Authors: Brant F, Miranda A, Esper L, Rodrigues D, Kangussu L, Bonaventura D, Soriani F, Pinho V, Souza D, Rachid M, Weiss L, Tanowitz H, Teixeira M, Teixeira A, Machado F
Infect Immun, 2014;82(8):3127-40.
Species: Mouse
Sample Type: Homogenized Tissue

Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor.
Authors: Goncalves-de-Albuquerque C, Burth P, Silva A, de Moraes I, Oliveira F, Santelli R, Freire A, de Lima G, da Silva E, da Silva C, Morandi V, Bozza P, Younes-Ibrahim M, de Castro Faria Neto H, de Castro Faria M
Respir Res, 2014;15(0):93.
Species: Mouse
Sample Type: BALF

Sustained Na+/H+ exchanger activation promotes gliotransmitter release from reactive hippocampal astrocytes following oxygen-glucose deprivation.
Authors: Cengiz P, Kintner D, Chanana V, Yuan H, Akture E, Kendigelen P, Begum G, Fidan E, Uluc K, Ferrazzano P, Sun D
PLoS ONE, 2014;9(1):e84294.
Species: Mouse
Sample Type: cell culture supernate

MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection.
Authors: Berod L, Stuve P, Swallow M, Arnold-Schrauf C, Kruse F, Gentilini M, Freitag J, Holzmann B, Sparwasser T
Eur J Immunol, 2014;44(5):1399-409.
Species: Mouse
Sample Type: Serum

Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Authors: Ataide M, Andrade W, Zamboni D, Wang D, Souza M, Franklin B, Elian S, Martins F, Pereira D, Reed G, Fitzgerald K, Golenbock D, Gazzinelli R
PLoS Pathog, 2014;10(1):e1003885.
Species: Mouse
Sample Type: Blood

Dendritic cell IL-1alpha and IL-1beta are polyubiquitinated and degraded by the proteasome.
Authors: Ainscough J, Frank Gerberick G, Zahedi-Nejad M, Lopez-Castejon G, Brough D, Kimber I, Dearman R
J Biol Chem, 2014;289(51):35582-92.
Species: Mouse
Sample Type: Cell Lysates

Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer.
Authors: Viennois E, Xiao B, Ayyadurai S, Wang L, Wang P, Zhang Q, Chen Y, Merlin D
Lab Invest, 2014;94(9):950-65.
Species: Mouse
Sample Type: cell supernates

ASC in renal collecting duct epithelial cells contributes to inflammation and injury after unilateral ureteral obstruction.
Authors: Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S, Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M
Am J Pathol, 2014;184(5):1287-98.
Species: Mouse
Sample Type: Cell culture supernatant

The role of Nox2-derived ROS in the development of cognitive impairment after sepsis.
Authors: Hernandes M, DAvila J, Trevelin S, Reis P, Kinjo E, Lopes L, Castro-Faria-Neto H, Cunha F, Britto L, Bozza F
J Neuroinflammation, 2014;11(0):36.
Species: Mouse
Sample Type: Peritoneal Fluid

A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation.
Authors: Csoka B, Koscso B, Toro G, Kokai E, Virag L, Nemeth Z, Pacher P, Bai P, Hasko G
Diabetes, 2014;63(3):850-66.
Species: Mouse
Sample Type: Plasma

Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model.
Authors: Everitt, Aaron R, Clare, Simon, McDonald, Jacqueli, Kane, Leanne, Harcourt, Katherin, Ahras, Malika, Lall, Amar, Hale, Christin, Rodgers, Angela, Young, Douglas, Haque, Ashraful, Billker, Oliver, Tregoning, John S, Dougan, Gordon, Kellam, Paul
PLoS ONE, 2013;8(11):e80723.
Species: Mouse
Sample Type: BALF

Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation.
Authors: Horton J, Hudak K, Chung E, White A, Scroggins B, Burkeen J, Citrin D
Stem Cells, 2013;31(10):2231-41.
Species: Mouse
Sample Type: Tissue Homogenates

A pseudopterane diterpene isolated from the octocoral Pseudopterogorgia acerosa inhibits the inflammatory response mediated by TLR-ligands and TNF-alpha in macrophages.
Authors: Gonzalez Y, Doens D, Santamaria R, Ramos M, Restrepo C, Barros de Arruda L, Lleonart R, Gutierrez M, Fernandez P
PLoS ONE, 2013;8(12):e84107.
Species: Mouse
Sample Type: cell culture supernate

NLRP3 inflammasome activation by Paracoccidioides brasiliensis.
Authors: Tavares A, Magalhaes K, Almeida R, Correa R, Burgel P, Bocca A
PLoS Negl Trop Dis, 2013;7(12):e2595.
Species: Mouse
Sample Type: Cell Culture Supernates

Further evidence for an anti-inflammatory role of artesunate in experimental cerebral malaria.
Authors: Miranda A, Brant F, Rocha N, Cisalpino D, Rodrigues D, Souza D, Machado F, Rachid M, Teixeira A, Campos A
Malar J, 2013;12(0):388.
Species: Mouse
Sample Type: Tissue Homogenates

The lung inflammation and skeletal muscle wasting induced by subchronic cigarette smoke exposure are not altered by a high-fat diet in mice.
Authors: Hansen, Michelle, Chen, Hui, Jones, Jessica, Langenbach, Shenna Y, Vlahos, Ross, Gualano, Rosa C, Morris, Margaret, Anderson, Gary P
PLoS ONE, 2013;8(11):e80471.
Species: Mouse
Sample Type: Tissue Homogenates

Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice.
Authors: Waddell A, Ahrens R, Tsai Y, Sherrill J, Denson L, Steinbrecher K, Hogan S
J Immunol, 2013;190(9):4773-85.
Species: Mouse
Sample Type: Cell Culture Supernates

Dok2 mediates the CD200Fc attenuation of Abeta-induced changes in glia.
Authors: Lyons A, Downer E, Costello D, Murphy N, Lynch M
J Neuroinflammation, 2012;9(0):107.
Species: Mouse
Sample Type: cell supernates

Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury.
Authors: Sato A, Ohtaki H, Tsumuraya T, Song D, Ohara K, Asano M, Iwakura Y, Atsumi T, Shioda S
J Neuroinflammation, 2012;9(0):65.
Species: Mouse
Sample Type: Tissue Homogenates

Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response.
Authors: Oh J, Lee R, Yu J, Ko J, Lee H, Ko A, Roddy G, Prockop D
Mol Ther, 2012;20(11):2143-52.
Species: Mouse
Sample Type: Tissue Homogenates

Influence of hypoxia-inducible factor 1-alpha on dendritic cell differentiation and migration.
Authors: Kohler T, Reizis B, Johnson RS, Weighardt H, Forster I
Eur. J. Immunol., 2012;42(5):1226-36.
Species: Mouse
Sample Type: Cell Culture Supernates

Macrophage Dectin-1 Expression Is Controlled by Leukotriene B4 via a GM-CSF/PU.1 Axis.
Authors: Serezani CH, Kane S, Collins L
J. Immunol., 2012;189(2):906-15.
Species: Mouse
Sample Type: BALF

Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection.
Authors: Veliz Rodriguez T, Moalli F, Polentarutti N, Paroni M, Bonavita E, Anselmo A, Nebuloni M, Mantero S, Jaillon S, Bragonzi A, Mantovani A, Riva F, Garlanda C
Infect. Immun., 2012;80(1):100-9.
Species: Mouse
Sample Type: Serum

TLR9 and MyD88 are crucial for the development of protective immunity to malaria.
Authors: Gowda NM, Wu X, Gowda DC
J. Immunol., 2012;188(10):5073-85.
Species: Mouse
Sample Type: Cell Culture Supernates

The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in Chronic Lung Infection Caused by Pseudomonas aeruginosa.
Authors: Moalli F, Paroni M, Veliz Rodriguez T, Riva F, Polentarutti N, Bottazzi B, Valentino S, Mantero S, Nebuloni M, Mantovani A, Bragonzi A, Garlanda C
J. Immunol., 2011;186(9):5425-34.
Species: Mouse
Sample Type: Tissue Homogenates

CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition.
Authors: Barber DL, Mayer-Barber KD, Feng CG
J. Immunol., 2011;186(3):1598-607.
Species: Mouse
Sample Type: BALF

The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
Authors: El-Behi M, Ciric B, Dai H
Nat. Immunol., 2011;12(6):568-75.
Species: Mouse
Sample Type: Cell Culture Supernates

Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity.
Authors: Sellge G, Magalhaes JG, Konradt C, Fritz JH, Salgado-Pabon W, Eberl G, Bandeira A, Di Santo JP, Sansonetti PJ, Phalipon A
J. Immunol., 2010;184(4):2076-85.
Species: Mouse
Sample Type: Cell Culture Supernates

A critical role for C5L2 in the pathogenesis of experimental allergic asthma.
Authors: Zhang X, Schmudde I, Laumonnier Y, Pandey MK, Clark JR, Konig P, Gerard NP, Gerard C, Wills-Karp M, Kohl J
J. Immunol., 2010;185(11):6741-52.
Species: Mouse
Sample Type: Cell Culture Supernates

Tyrosine kinase 2 controls IL-1beta production at the translational level.
Authors: Radwan M, Stiefvater R, Grunert T, Sharif O, Miller I, Marchetti-Deschmann M, Allmaier G, Gemeiner M, Knapp S, Kovarik P, Muller M, Strobl B
J. Immunol., 2010;185(6):3544-53.
Species: Mouse
Sample Type: Cell Culture Supernates

Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5.
Authors: Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S, Sitaraman SV, Knight R, Ley RE, Gewirtz AT
Science, 2010;328(5975):228-31.
Species: Mouse
Sample Type: Cell Culture Supernates

Toll-like receptor 4 mediates the response of epithelial and stromal cells to lipopolysaccharide in the endometrium.
Authors: Sheldon IM, Roberts MH,
PLoS ONE, 2010;5(9):e12906.
Species: Mouse
Sample Type: Cell Culture Supernates

P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases.
Authors: Lopez-Castejon G, Theaker J, Pelegrin P
J. Immunol., 2010;185(4):2611-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens.
Authors: Burton OT, Gibbs S, Miller N, Jones FM, Wen L, Dunne DW, Cooke A, Zaccone P
Eur. J. Immunol., 2010;40(8):2221-9.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-27 mediates the response to IFN-beta therapy in multiple sclerosis patients by inhibiting Th17 cells.
Authors: Sweeney CM, Lonergan R, Basdeo SA, Kinsella K, Dungan LS, Higgins SC, Kelly PJ, Costelloe L, Tubridy N, Mills KH, Fletcher JM
Brain Behav. Immun., 2010;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

Distinct roles of hepatocyte- and myeloid cell-derived IL-1 receptor antagonist during endotoxemia and sterile inflammation in mice.
Authors: Lamacchia C, Palmer G, Bischoff L, Rodriguez E, Talabot-Ayer D, Gabay C
J. Immunol., 2010;185(0):2516-24.
Species: Mouse
Sample Type: Serum

The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages.
Authors: Scatizzi JC, Mavers M, Hutcheson J, Young B, Shi B, Pope RM, Ruderman EM, Samways DS, Corbett JA, Egan TM, Perlman H
Eur. J. Immunol., 2009;39(3):820-5.
Species: Mouse
Sample Type: Cell Culture Supernates

A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARgamma-mediated suppression of toll-like receptor 4.
Authors: Reynolds CM, Draper E, Keogh B, Rahman A, Moloney AP, Mills KH, Loscher CE, Roche HM
J. Nutr., 2009;139(12):2351-7.
Species: Mouse
Sample Type: Serum

Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy.
Authors: Jaffre F, Bonnin P, Callebert J, Debbabi H, Setola V, Doly S, Monassier L, Mettauer B, Blaxall BC, Launay JM, Maroteaux L
Circ. Res., 2009;104(1):113-23.
Species: Mouse
Sample Type: Plasma

E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection.
Authors: Aronoff DM, Lewis C, Serezani CH, Eaton KA, Goel D, Phipps JC, Peters-Golden M, Mancuso P
J. Immunol., 2009;183(4):2642-9.
Species: Mouse
Sample Type: BALF

TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia.
Authors: Lagler H, Sharif O, Haslinger I, Matt U, Stich K, Furtner T, Doninger B, Schmid K, Gattringer R, de Vos AF, Knapp S
J. Immunol., 2009;183(3):2027-36.
Species: Mouse
Sample Type: Tissue Homogenates

IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema.
Authors: Couillin I, Vasseur V, Charron S, Gasse P, Tavernier M, Guillet J, Lagente V, Fick L, Jacobs M, Coelho FR, Moser R, Ryffel B
J. Immunol., 2009;183(12):8195-202.
Species: Mouse
Sample Type: BALF

Divergent effects of hypoxia on dendritic cell functions.
Authors: Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen IH, Sozzani S, Austyn JM, Mantovani A, Sica A
Blood, 2008;112(9):3723-34.
Species: Mouse
Sample Type: Cell Culture Supernates

Induction of IL-33 expression and activity in central nervous system glia.
Authors: Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT
J. Leukoc. Biol., 2008;84(3):631-43.
Species: Mouse
Sample Type: Cell Culture Supernates

Mutual modulation between interleukin-10 and interleukin-6 induced by Rhodococcus aurantiacus infection in mice.
Authors: Yimin, Kohanawa M, Ozaki M, Haga S, Fujikawa K, Zhao S, Kuge Y, Tamaki N
Microbes Infect., 2008;10(14):1450-8.
Species: Mouse
Sample Type: Cell Culture Supernates

Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis.
Authors: Kaya Z, Goser S, Buss SJ, Leuschner F, Ottl R, Li J, Volkers M, Zittrich S, Pfitzer G, Rose NR, Katus HA
Circulation, 2008;118(20):2063-72.
Species: Mouse
Sample Type: Cell Culture Supernates

Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent.
Authors: Doz E, Noulin N, Boichot E, Guenon I, Fick L, Le Bert M, Lagente V, Ryffel B, Schnyder B, Quesniaux VF, Couillin I
J. Immunol., 2008;180(2):1169-78.
Species: Mouse
Sample Type: Tissue Homogenates

Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection.
Authors: Bozza S, Zelante T, Moretti S, Bonifazi P, DeLuca A, DAngelo C, Giovannini G, Garlanda C, Boon L, Bistoni F, Puccetti P, Mantovani A, Romani L
J. Immunol., 2008;180(6):4022-31.
Species: Mouse
Sample Type: Cell Culture Supernates

Deletion of TLR5 results in spontaneous colitis in mice.
Authors: Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT
J. Clin. Invest., 2007;117(12):3909-21.
Species: Mouse
Sample Type: Serum

Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis.
Authors: Hegde A, Zhang H, Moochhala SM, Bhatia M
J. Leukoc. Biol., 2007;82(3):678-85.
Species: Mouse
Sample Type: Plasma

CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.
Authors: Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J
Neurobiol. Dis., 2007;29(2):336-53.
Species: Mouse
Sample Type: Plasma

Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes.
Authors: Tjwa M, Bellido-Martin L, Lin Y, Lutgens E, Plaisance S, Bono F, Delesque-Touchard N, Herve C, Moura R, Billiau AD, Aparicio C, Levi M, Daemen M, Dewerchin M, Lupu F, Arnout J, Herbert JM, Waer M, Garcia de Frutos P, Dahlback B, Carmeliet P, Hoylaerts MF, Moons L
Blood, 2007;111(8):4096-105.
Species: Mouse
Sample Type: Cell Culture Supernates

Lactoferrin enhanced efficacy of the BCG vaccine to generate host protective responses against challenge with virulent Mycobacterium tuberculosis.
Authors: Hwang SA, Wilk KM, Budnicka M, Olsen M, Bangale YA, Hunter RL, Kruzel ML, Actor JK
Vaccine, 2007;25(37):6730-43.
Species: Mouse
Sample Type: Cell Culture Supernates

ABCC transporter inhibition reduces zymosan-induced peritonitis.
Authors: Leite DF, Echevarria-Lima J, Ferreira SC, Calixto JB, Rumjanek VM
J. Leukoc. Biol., 2007;82(3):630-7.
Species: Mouse
Sample Type: Peritoneal Exudate

IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.
Authors: Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I
J. Clin. Invest., 2007;117(12):3786-99.
Species: Mouse
Sample Type: BALF

Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.
Authors: Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ
Immunity, 2007;26(4):445-59.
Species: Mouse
Sample Type: Cell Culture Supernates

Differential ex vivo nitric oxide production by acutely isolated neonatal and adult microglia.
Authors: Schell JB, Crane CA, Smith MF, Roberts MR
J. Neuroimmunol., 2007;189(1):75-87.
Species: Mouse
Sample Type: Cell Culture Supernates

Involvement of vitronectin in lipopolysaccaride-induced acute lung injury.
Authors: Tsuruta Y, Park YJ, Siegal GP, Liu G, Abraham E
J. Immunol., 2007;179(10):7079-86.
Species: Mouse
Sample Type: Tissue Homogenates

Glucose-6-phosphate dehydrogenase deficiency and the inflammatory response to endotoxin and polymicrobial sepsis.
Authors: Wilmanski J, Villanueva E, Deitch EA, Spolarics Z
Crit. Care Med., 2007;35(2):510-8.
Species: Mouse
Sample Type: Plasma

The effects of dehydroepiandrosterone (DHEA) on in vitro spleen cell proliferation and cytokine production.
Authors: Powell JM, Sonnenfeld G
J. Interferon Cytokine Res., 2006;26(1):34-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Choosing the frequency of deep inflation in mice: balancing recruitment against ventilator-induced lung injury.
Authors: Allen GB, Suratt BT, Rinaldi L, Petty JM, Bates JH
Am. J. Physiol. Lung Cell Mol. Physiol., 2006;291(4):L710-7.
Species: Mouse
Sample Type: BALF

Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals.
Authors: Scott P, Ma H, Viriyakosol S, Terkeltaub R, Liu-Bryan R
J. Immunol., 2006;177(9):6370-8.
Species: Mouse
Sample Type: Cell Culture Supernates

TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells.
Authors: Higgins SC, Jarnicki AG, Lavelle EC, Mills KH
J. Immunol., 2006;177(11):7980-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Anti-tumor necrosis factor alpha F(ab)2 antibody fragments protect in murine polymicrobial sepsis: concentration and early intervention are fundamental to the outcome.
Authors: Marquez-Velasco R, Bojalil R, Buelna A, Flores-Guzman F, Estevez-Ramirez J, Laguna J, Hernandez AM, Diaz-Quinonez A, Paniagua-Solis JF
Inflamm. Res., 2006;55(9):378-84.
Species: Mouse
Sample Type: Serum

Attenuation of primary nonfunction for syngeneic islet graft using sodium 4-phenylbutyrate.
Authors: Fu SH, Chen ST, Hsu BR
Transplant. Proc., 2005;37(4):1830-1.
Species: Mouse
Sample Type: Cell Culture Supernates

An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia.
Authors: Hajjar AM, Harowicz H, Liggitt HD, Fink PJ, Wilson CB, Skerrett SJ
Am. J. Respir. Cell Mol. Biol., 2005;33(5):470-5.
Species: Mouse
Sample Type: Tissue Homogenates

Anti-inflammatory activity in the aqueous crude extract of the leaves of Nidularium procerum: A bromeliaceae from the Brazilian coastal rain forest.
Authors: Amendoeira FC, Frutuoso VS, Zanon C, Chedier LM, Figueiredo MR, Kaplan MA, Bandeira-Melo C, Bozza PT, Castro-Faria-Neto HC
Biol. Pharm. Bull., 2005;28(6):1010-5.
Species: Mouse
Sample Type: Pleural Fluid

Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions.
Authors: Aviles H, Belay T, Vance M, Sun B, Sonnenfeld G
J. Appl. Physiol., 2004;97(4):1437-44.
Species: Mouse
Sample Type: Cell Culture Supernates

Toll-like receptor 2 (TLR2) mediates astrocyte activation in response to the Gram-positive bacterium Staphylococcus aureus.
Authors: Esen N, Tanga FY, DeLeo JA, Kielian T
J. Neurochem., 2004;88(3):746-58.
Species: Mouse
Sample Type: Cell Culture Supernates

TLR2 deletion promotes arthritis through reduction of IL-10.
Authors: Huang Q, Koessler R, Birkett R, Perlman H, Xing L, Pope R
J Leukoc Biol, 0;93(5):751-9.
Species: Mouse
Sample Type: Tissue Homogenates

背景IL-1 beta (Interleukin-1 beta) is produced in response to inflammatory agents, infections, or microbial endotoxins. It plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction, and IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 bioactivity.
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