High endogenous activated protein C levels attenuates bleomycin-induced pulmonary fibrosis
Authors: Cong Lin
J Cell Mol Med, 2016;0(0):.
Species: Mouse
Sample Type: Tissue Homogenates

Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis
PLoS ONE, 2016;11(5):e0154630.
Species: Mouse
Sample Type: Cell Culture Supernates

Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Mouse
Sample Type: BALF

Proinflammatory M1 macrophages inhibit RANKL-induced osteoclastogenesis
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates

Differential Immunometabolic Phenotype in Th1 and Th2 Dominant Mouse Strains in Response to High-Fat Feeding.
Authors: Jovicic N, Jeftic I, Jovanovic I, Radosavljevic G, Arsenijevic N, Lukic M, Pejnovic N
PLoS ONE, 2015;10(7):e0134089.
Species: Mouse
Sample Type: Tissue Homogenates

Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice.
Authors: Li Y, Chen H, Bannick N, Henry M, Holm A, Metwali A, Urban J, Rothman P, Weiner G, Blazar B, Elliott D, Ince M
J Immunol, 2015;194(3):1011-20.
Species: Mouse
Sample Type: Cell Culture Supernates

Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation.
Authors: Horton J, Hudak K, Chung E, White A, Scroggins B, Burkeen J, Citrin D
Stem Cells, 2013;31(10):2231-41.
Species: Mouse
Sample Type: Tissue Homogenates

Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection.
Authors: Veliz Rodriguez T, Moalli F, Polentarutti N, Paroni M, Bonavita E, Anselmo A, Nebuloni M, Mantero S, Jaillon S, Bragonzi A, Mantovani A, Riva F, Garlanda C
Infect. Immun., 2012;80(1):100-9.
Species: Mouse
Sample Type: Serum

Toll-like Receptor 2 (TLR2), Transforming Growth Factor-beta, Hyaluronan (HA), and Receptor for HA-mediated Motility (RHAMM) Are Required for Surfactant Protein A-stimulated Macrophage Chemotaxis.
Authors: Foley J, Lam D, Jiang H, Liao J, Cheong N, McDevitt T, Zaman A, Wright J, Savani R
J Biol Chem, 2012;287(44):37406-19.
Species: Human
Sample Type: Cell Culture Supernates

High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism.
Authors: Nakagome K, Imamura M, Kawahata K
J. Immunol., 2011;187(10):5077-89.
Species: Mouse
Sample Type: BALF

The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in Chronic Lung Infection Caused by Pseudomonas aeruginosa.
Authors: Moalli F, Paroni M, Veliz Rodriguez T, Riva F, Polentarutti N, Bottazzi B, Valentino S, Mantero S, Nebuloni M, Mantovani A, Bragonzi A, Garlanda C
J. Immunol., 2011;186(9):5425-34.
Species: Mouse
Sample Type: Tissue Homogenates

Phosphoinositide 3-kinase gamma plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice.
Authors: Russo RC, Garcia CC, Barcelos LS, Rachid MA, Guabiraba R, Roffe E, Souza AL, Sousa LP, Mirolo M, Doni A, Cassali GD, Pinho V, Locati M, Teixeira MM
J. Leukoc. Biol., 2011;89(2):269-82.
Species: Mouse
Sample Type: Tissue Homogenates

Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens.
Authors: Burton OT, Gibbs S, Miller N, Jones FM, Wen L, Dunne DW, Cooke A, Zaccone P
Eur. J. Immunol., 2010;40(8):2221-9.
Species: Mouse
Sample Type: Cell Culture Supernates

A critical role for C5L2 in the pathogenesis of experimental allergic asthma.
Authors: Zhang X, Schmudde I, Laumonnier Y, Pandey MK, Clark JR, Konig P, Gerard NP, Gerard C, Wills-Karp M, Kohl J
J. Immunol., 2010;185(11):6741-52.
Species: Mouse
Sample Type: Cell Culture Supernates

Latent herpesvirus infection augments experimental pulmonary fibrosis.
Authors: Vannella KM, Luckhardt TR, Wilke CA, van Dyk LF, Toews GB, Moore BB
Am. J. Respir. Crit. Care Med., 2010;181(5):465-77.
Species: Mouse
Sample Type: Cell Culture Supernates

Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity.
Authors: Sellge G, Magalhaes JG, Konradt C, Fritz JH, Salgado-Pabon W, Eberl G, Bandeira A, Di Santo JP, Sansonetti PJ, Phalipon A
J. Immunol., 2010;184(4):2076-85.
Species: Mouse
Sample Type: Cell Culture Supernates

T-cell polarization depends on concentration of the danger signal used to activate dendritic cells.
Authors: Peters M, Dudziak K, Stiehm M
Immunol. Cell Biol., 2010;88(5):537-44.
Species: Mouse
Sample Type: Cell Culture Supernates

Mucosal immunity in mice induced by orally administered transgenic rice.
Authors: Zhang X, Yuan Z, Duan Q, Zhu H, Yu H, Wang Q
Vaccine, 2009;27(10):1596-600.
Species: Mouse
Sample Type: Cell Culture Supernates

Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy.
Authors: Jaffre F, Bonnin P, Callebert J, Debbabi H, Setola V, Doly S, Monassier L, Mettauer B, Blaxall BC, Launay JM, Maroteaux L
Circ. Res., 2009;104(1):113-23.
Species: Mouse
Sample Type: Plasma

BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells.
Authors: Mani M, Carrasco DE, Zhang Y, Takada K, Gatt ME, Dutta-Simmons J, Ikeda H, Diaz-Griffero F, Pena-Cruz V, Bertagnolli M, Myeroff LL, Markowitz SD, Anderson KC, Carrasco DR
Cancer Res., 2009;69(19):7577-86.
Species: Mouse
Sample Type: Cell Culture Supernates

Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts.
Authors: Salazar KD, Lankford SM, Brody AR
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;297(5):L1002-11.
Species: Mouse
Sample Type: Cell Culture Supernates

CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1.
Authors: Han Y, Guo Q, Zhang M, Chen Z, Cao X
J. Immunol., 2009;182(1):111-20.
Species: Mouse
Sample Type: Cell Culture Supernates

Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1.
Authors: Zhou G, Dada LA, Wu M, Kelly A, Trejo H, Zhou Q, Varga J, Sznajder JI
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;297(6):L1120-30.
Species: Rat
Sample Type: Cell Culture Supernates

In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis.
Authors: Fineschi S, Bongiovanni M, Donati Y, Djaafar S, Naso F, Goffin L, Argiroffo CB, Pache JC, Dayer JM, Ferrari-Lacraz S, Chizzolini C
Am. J. Respir. Cell Mol. Biol., 2008;39(4):458-65.
Species: Mouse
Sample Type: BALF

Expression of inflammatory mediators in the otitis media induced by Helicobacter pylori antigen in mice.
Authors: Kariya S, Okano M, Fukushima K, Nomiya S, Kataoka Y, Nomiya R, Akagi H, Nishizaki K
Clin. Exp. Immunol., 2008;154(1):134-40.
Species: Mouse
Sample Type: middle ear wash

Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling.
Authors: Fattouh R, Midence NG, Arias K, Johnson JR, Walker TD, Goncharova S, Souza KP, Gregory RC, Lonning S, Gauldie J, Jordana M
Am. J. Respir. Crit. Care Med., 2008;177(6):593-603.
Species: Mouse
Sample Type: BALF

Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection.
Authors: Bozza S, Zelante T, Moretti S, Bonifazi P, DeLuca A, DAngelo C, Giovannini G, Garlanda C, Boon L, Bistoni F, Puccetti P, Mantovani A, Romani L
J. Immunol., 2008;180(6):4022-31.
Species: Mouse
Sample Type: Tissue Homogenates

Methylprednisolone improves lung mechanics and reduces the inflammatory response in pulmonary but not in extrapulmonary mild acute lung injury in mice.
Authors: Leite-Junior JH, Garcia CS, Souza-Fernandes AB, Silva PL, Ornellas DS, Larangeira AP, Castro-Faria-Neto HC, Morales MM, Negri EM, Capelozzi VL, Zin WA, Pelosi P, Bozza PT, Rocco PR
Crit. Care Med., 2008;36(9):2621-8.
Species: Mouse
Sample Type: BALF

Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity.
Authors: Presser K, Schwinge D, Wegmann M, Huber S, Schmitt S, Quaas A, Maxeiner JH, Finotto S, Lohse AW, Blessing M, Schramm C
J. Immunol., 2008;181(11):7751-8.
Species: Mouse
Sample Type: BALF

CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.
Authors: Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J
Neurobiol. Dis., 2007;29(2):336-53.
Species: Mouse
Sample Type: Plasma

Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.
Authors: Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ
Immunity, 2007;26(4):445-59.
Species: Mouse
Sample Type: Cell Culture Supernates

Dual effect of AMD3100, a CXCR4 antagonist, on bleomycin-induced lung inflammation.
Authors: Watanabe M, Matsuyama W, Shirahama Y, Mitsuyama H, Oonakahara K, Noma S, Higashimoto I, Osame M, Arimura K
J. Immunol., 2007;178(9):5888-98.
Species: Mouse
Sample Type: Tissue Homogenates

Poly(ADP-ribose) polymerase-1 (PARP-1) controls lung cell proliferation and repair after hyperoxia-induced lung damage.
Authors: Pagano A, Metrailler-Ruchonnet I, Aurrand-Lions M, Lucattelli M, Donati Y, Argiroffo CB
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(3):L619-29.
Species: Mouse
Sample Type: BALF

Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis.
Authors: Ephrem A, Chamat S, Miquel C, Fisson S, Mouthon L, Caligiuri G, Delignat S, Elluru S, Bayry J, Lacroix-Desmazes S, Cohen JL, Salomon BL, Kazatchkine MD, Kaveri SV, Misra N
Blood, 2007;111(2):715-22.
Species: Mouse
Sample Type: Cell Culture Supernates

Induction of prolonged infiltration of T lymphocytes and transient T lymphocyte-dependent collagen deposition in mouse lungs following adenoviral gene transfer of CCL18.
Authors: Luzina IG, Papadimitriou JC, Anderson R, Pochetuhen K, Atamas SP
Arthritis Rheum., 2006;54(8):2643-55.
Species: Mouse
Sample Type: BALF

Hierarchical suppression of asthma-like responses by mucosal tolerance.
Authors: Keller AC, Mucida D, Gomes E, Faquim-Mauro E, Faria AM, Rodriguez D, Russo M
J. Allergy Clin. Immunol., 2006;117(2):283-90.
Species: Mouse
Sample Type: Cell Culture Supernates

Inhibition of angiogenesis by interleukin-4 gene therapy in rat adjuvant-induced arthritis.
Authors: Haas CS, Amin MA, Allen BB, Ruth JH, Haines GK, Woods JM, Koch AE
Arthritis Rheum., 2006;54(8):2402-14.
Species: Rat
Sample Type: Tissue Homogenates

Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.

TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic cysteine knot. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.