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Human IL-10 DuoSet ELISA, 5 Plate (1 KT)

货号: DY217B-05 基本售价: 3882.5 元 规格: 1 KIT

产品信息

概述
货号DY217B-05
别名
CSIF; CSIFMGC126450; Cytokine synthesis inhibitory factor; IL10; IL-10; IL10A; IL-10MGC126451; interleukin 10; interleukin-10; TGIF
全称Interleukin 10
反应种属Human
目标/特异性Please see the product datasheet
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs3586 (Human); 16153 (Mouse); 25325 (Rat); 397106 (Porcine); 403628 (Canine); 493683 (Feline); 100135553 (Guinea Pig); 2949786 (Viral);
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells.
Authors: Saulep-Easton D, Vincent F, Quah P, Wei A, Ting S, Croce C, Tam C, Mackay F
Leukemia, 2016;30(1):163-72.
Species: Human
Sample Type: Cell Culture Supernates

Acanthamoeba castellanii (Genotype T4) Stimulates the Production of Interleukin-10 as well as Pro-inflammatory Cytokines in THP-1 Cells, Human Peripheral Blood Mononuclear Cells and Human Monocyte-Derived Macrophages
Infect Immun, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Soluble alpha-enolase activates monocytes by CD14-dependent TLR4 signalling pathway and exhibits a dual function
Authors: C Guillou, M Fréret, E Fondard, C Derambure, G Avenel, ML Golinski, M Verdet, O Boyer, F Caillot, P Musette, T Lequerré, O Vittecoq
Sci Rep, 2016;6(0):23796.
Species: Human
Sample Type: Cell Culture Supernates

Genetic polymorphisms of cell adhesion molecules in Behcet's disease in a Chinese Han population
Authors: M Zheng, L Zhang, H Yu, J Hu, Q Cao, G Huang, Y Huang, G Yuan, A Kijlstra, P Yang
Sci Rep, 2016;6(0):24974.
Species: Human
Sample Type: Cell Culture Supernates

Analysis of receptor tyrosine kinase genetics identifies two novel risk loci in GAS6 and PROS1 in Beh�et's disease
Sci Rep, 2016;6(0):26662.
Species: Human
Sample Type: Cell Culture Supernates

In vitro progesterone modulation on bacterial endotoxin-induced production of IL-1beta, TNFalpha, IL-6, IL-8, IL-10, MIP-1alpha, and MMP-9 in pre-labor human term placenta.
Authors: Garcia-Ruiz G, Flores-Espinosa P, Preciado-Martinez E, Bermejo-Martinez L, Espejel-Nunez A, Estrada-Gutierrez G, Maida-Claros R, Flores-Pliego A, Zaga-Clavellina V
Reprod Biol Endocrinol, 2015;13(0):115.
Species: Human
Sample Type: Cell Culture Supernates

Exposure to diesel exhaust particle extracts (DEPe) impairs some polarization markers and functions of human macrophages through activation of AhR and Nrf2.
Authors: Jaguin M, Fardel O, Lecureur V
PLoS ONE, 2015;10(2):e0116560.
Species: Human
Sample Type: Cell Culture Supernates

The effects of cytokines on spontaneous hepatitis B surface antigen seroconversion in chronic hepatitis B virus infection.
Authors: Wu J, Hsu H, Chiu Y, Chen H, Ni Y, Chang M
J Immunol, 2015;194(2):690-6.
Species: Human
Sample Type: Serum

Sourcing of an alternative pericyte-like cell type from peripheral blood in clinically relevant numbers for therapeutic angiogenic applications.
Authors: Blocki A, Wang Y, Koch M, Goralczyk A, Beyer S, Agarwal N, Lee M, Moonshi S, Dewavrin J, Peh P, Schwarz H, Bhakoo K, Raghunath M
Mol Ther, 2015;23(3):510-22.
Species: Human
Sample Type: Cell Culture Supernates

LPS-Stimulated Whole Blood Cytokine Production Is Not Related to Disease Behavior in Patients with Quiescent Crohn's Disease.
Authors: Broekman M, Roelofs H, Hoentjen F, Wiegertjes R, Stoel N, Joosten L, de Jong D, Wanten G
PLoS ONE, 2015;10(7):e0133932.
Species: Human
Sample Type: Plasma

Characterization of host and microbial determinants in individuals with latent tuberculosis infection using a human granuloma model.
Authors: Guirado E, Mbawuike U, Keiser T, Arcos J, Azad A, Wang S, Schlesinger L
MBio, 2015;6(1):e02537-14.
Species: Human
Sample Type: cell supernates

CD137 ligand signalling induces differentiation of primary acute myeloid leukaemia cells.
Authors: Cheng K, Wong S, Linn Y, Ho L, Chng W, Schwarz H
Br J Haematol, 2014;165(1):134-44.
Species: Human
Sample Type: Cell Culture Supernates

Human CD4+ T cell responses to the dog major allergen Can f 1 and its human homologue tear lipocalin resemble each other.
Authors: Liukko A, Kinnunen T, Rytkonen-Nissinen M, Kailaanmaki A, Randell J, Maillere B, Virtanen T
PLoS ONE, 2014;9(5):e98461.
Species: Human
Sample Type: Cell Culture Supernates

Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive.
Authors: OToole A, Michielsen A, Nolan B, Tosetto M, Sheahan K, Mulcahy H, Winter D, Hyland J, OConnell P, Fennelly D, ODonoghue D, OSullivan J, Doherty G, Ryan E
Br J Cancer, 2014;111(5):927-32.
Species: Human
Sample Type: Cell Culture Supernates

Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion.
Authors: Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, Nutman T, Semnani R
Infect Immun, 2013;81(5):1420-9.
Species: Human
Sample Type: Cell Culture Supernates

Leishmania braziliensis-reactive T cells are down-regulated in long-term cured cutaneous Leishmaniasis, but the renewal capacity of T effector memory compartments is preserved.
Authors: Pereira-Carvalho R, Mendes-Aguiar C, Oliveira-Neto M, Covas C, Bertho A, Da-Cruz A, Gomes-Silva A
PLoS ONE, 2013;8(11):e81529.
Species: Human
Sample Type: Cell Culture Supernates

Association of TLR2 gene polymorphisms with ocular Behcet's disease in a Chinese Han population.
Authors: Fang J, Hu R, Hou S, Ye Z, Xiang Q, Qi J, Zhou Y, Kijlstra A, Yang P
Invest Ophthalmol Vis Sci, 2013;54(13):8384-92.
Species: Human
Sample Type: Cell Culture Supernates

Selective activation of human dendritic cells by OM-85 through a NF-kB and MAPK dependent pathway.
Authors: Parola C, Salogni L, Vaira X, Scutera S, Somma P, Salvi V, Musso T, Tabbia G, Bardessono M, Pasquali C, Mantovani A, Sozzani S, Bosisio D
PLoS ONE, 2013;8(12):e82867.
Species: Human
Sample Type: cell culture supernate

Urinary neutrophil gelatinase-associated lipocalin is a potential biomarker for renal damage in patients with systemic lupus erythematosus.
Authors: Yang CC, Hsieh SC, Li KJ, Wu CH, Lu MC, Tsai CY, Yu CL
J. Biomed. Biotechnol., 2012;2012(0):759313.
Species: Human
Sample Type: Urine

Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti.
Authors: Arndts K, Deininger S, Specht S, Klarmann U, Mand S, Adjobimey T, Debrah AY, Batsa L, Kwarteng A, Epp C, Taylor M, Adjei O, Layland LE, Hoerauf A
PLoS Negl Trop Dis, 2012;6(4):e1611.
Species: Human
Sample Type: Cell Culture Supernates

Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation.
Eur J Clin Nutr, 2012;66(9):1072-4.
Species: Human
Sample Type: Serum

Characterization and function of the human macrophage dopaminergic system: implications for CNS disease and drug abuse.
J Neuroinflammation, 2012;9(0):203.
Species: Human
Sample Type: Cell Culture Supernates

Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).
Authors: Suh HS, Choi N, Tarassishin L, Lee SC
PLoS ONE, 2012;7(4):e35115.
Species: Human
Sample Type: Cell Culture Supernates

IFN-alpha blocks IL-17 production by peripheral blood mononuclear cells in Behcet's disease.
Authors: Liu X, Yang P, Wang C, Li F, Kijlstra A
Rheumatology (Oxford), 2011;50(2):293-8.
Species: Human
Sample Type: Cell Culture Supernates

Possible involvement of IL-21 and IL-10 on salivary IgA levels in chronic periodontitis subjects.
Authors: Napimoga MH, Nunes LH, Maciel AA, Demasi AP, Benatti BB, Santos VR, Bastos MF, de Miranda TS, Duarte PM
Scand. J. Immunol., 2011;74(6):596-602.
Species: Human
Sample Type: Tissue Homogenates

IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes.
Authors: Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, Garcovich S, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Immunol., 2010;184(9):4880-8.
Species: Human
Sample Type: Cell Culture Supernates

Immunoregulation of autocrine prolactin: suppressing the expression of costimulatory molecules and cytokines in T lymphocytes by prolactin receptor knockdown.
Authors: Xu D, Lin L, Lin X
Cell. Immunol., 2010;263(1):71-8.
Species: Human
Sample Type: Cell Culture Supernates

Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands.
Authors: Ochiel DO, Ghosh M, Fahey JV
J. Leukoc. Biol., 2010;88(3):435-44.
Species: Human
Sample Type: Cell Culture Supernates

Investigation of functional IL-10 gene polymorphism and IL-10 levels in acute graft-versus-host disease.
Authors: Resende RG, Correia-Silva Jde F, Arao TC, Silva TA, Abreu MH, Bittencourt H, Gomez RS
J. Clin. Immunol., 2010;30(3):465-73.
Species: Human
Sample Type: Saliva

PEGylation of interleukin-10 for the mitigation of enhanced pain states.
Authors: Soderquist RG, Milligan ED, Harrison JA, Chavez RA, Johnson KW, Watkins LR, Mahoney MJ
J Biomed Mater Res A, 2010;93(3):1169-79.
Species: Human
Sample Type: CSF

Anemia in Hodgkins lymphoma: the role of interleukin-6 and hepcidin.
Authors: Hohaus S, Massini G, Giachelia M, Vannata B, Bozzoli V, Cuccaro A, DAlo F, Larocca LM, Raymakers RA, Swinkels DW, Voso MT, Leone G
J. Clin. Oncol., 2010;28(15):2538-43.
Species: Human
Sample Type: Plasma

Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma.
Authors: Hohaus S, Giachelia M, Massini G, Vannata B, Criscuolo M, Martini M, DAlo F, Voso MT, Larocca LM, Leone G
Leuk. Res., 2009;33(10):1352-6.
Species: Human
Sample Type: Plasma

Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms.
Authors: Correale J, Farez M
J. Immunol., 2009;183(9):5999-6012.
Species: Human
Sample Type: Cell Culture Supernates

Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men.
Authors: Damsgaard CT, Lauritzen L, Calder PC, Kjaer TR, Frokiaer H
J. Nutr., 2009;139(7):1410-4.
Species: Human
Sample Type: Cell Culture Supernates

Divergent effects of hypoxia on dendritic cell functions.
Authors: Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen IH, Sozzani S, Austyn JM, Mantovani A, Sica A
Blood, 2008;112(9):3723-34.
Species: Human
Sample Type: Cell Culture Supernates

Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12.
Authors: Lamhamedi-Cherradi SE, Martin RE, Ito T, Kheradmand F, Corry DB, Liu YJ, Moyle M
J. Immunol., 2008;180(9):6000-9.
Species: Human
Sample Type: Cell Culture Supernates

Reduced response to adiponectin and lower abundance of adiponectin receptor proteins in type 2 diabetic monocytes.
Authors: Weigert J, Neumeier M, Wanninger J, Wurm S, Kopp A, Schober F, Filarsky M, Schaffler A, Zeitoun M, Aslanidis C, Buechler C
FEBS Lett., 2008;582(12):1777-82.
Species: Human
Sample Type: Cell Culture Supernates

Adenosine receptors in regulation of dendritic cell differentiation and function.
Authors: Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM
Blood, 2008;112(5):1822-31.
Species: Human
Sample Type: Cell Culture Supernates

Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells.
Authors: Spadaro M, Caorsi C, Ceruti P, Varadhachary A, Forni G, Pericle F, Giovarelli M
FASEB J., 2008;22(8):2747-57.
Species: Human
Sample Type: Cell Culture Supernates

Helminth infections associated with multiple sclerosis induce regulatory B cells.
Authors: Correale J, Farez M, Razzitte G
Ann. Neurol., 2008;64(2):187-99.
Species: Human
Sample Type: Cell Culture Supernates

Early cytokine responses after percutaneous magnetic resonance imaging guided laser thermoablation of malignant liver tumors.
Authors: Kallio R, Sequeiros R, Surcel HM, Ohtonen P, Kiviniemi H, Syrjala H
Cytokine, 2007;34(5):278-83.

Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2.
Authors: Clayton A, Mitchell JP, Court J, Mason MD, Tabi Z
Cancer Res., 2007;67(15):7458-66.

Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells.
Authors: Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, Lenoir J, Preisser L, Anegon I, Catala L, Ifrah N, Descamps P, Gamelin E, Gascan H, Hebbar M, Jeannin P
Blood, 2007;110(13):4319-30.
Species: Human
Sample Type: Cell Culture Supernates

The differential effect of Eriobotrya japonica hydrophilic leaf extract on cytokines production and modulation.
Authors: Matalka KZ, Ali D, Khawad AE, Qadan F
Cytokine, 2007;40(3):235-40.
Species: Human
Sample Type: Cell Culture Supernates

Airway remodelling in children with cystic fibrosis.
Authors: Hilliard TN, Regamey N, Shute JK, Nicholson AG, Alton EW, Bush A, Davies JC
Thorax, 2007;62(12):1074-80.

B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease.
Authors: Kawai T, Matsuyama T, Hosokawa Y, Makihira S, Seki M, Karimbux NY, Goncalves RB, Valverde P, Dibart S, Li YP, Miranda LA, Ernst CW, Izumi Y, Taubman MA
Am. J. Pathol., 2006;169(3):987-98.
Species: Human
Sample Type: Tissue Homogenates

Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation.
Authors: Smith EL, Finney HM, Nesbitt AM, Ramsdell F, Robinson MK
Immunology, 2006;119(2):203-11.

Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists.
Authors: Fritz JH, Girardin SE, Fitting C, Werts C, Mengin-Lecreulx D, Caroff M, Cavaillon JM, Philpott DJ, Adib-Conquy M
Eur. J. Immunol., 2005;35(8):2459-70.
Species: Human
Sample Type: Cell Culture Supernates

Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma.
Authors: Pound JD, Batth BK, Johannessen I, Wood K
J. Immunol., 2005;174(5):3015-23.
Species: Human
Sample Type: Cell Culture Supernates

Association of type 2 cytokines with hepatic fibrosis in human Schistosoma mansoni infection.
Authors: de Jesus AR, Magalhaes A, Miranda DG, Miranda RG, Araujo MI, de Jesus AA, Silva A, Santana LB, Pearce E, Carvalho EM
Infect. Immun., 2004;72(6):3391-7.
Species: Human
Sample Type: Cell Culture Supernates

The Toll-like receptor-2/6 agonist macrophage-activating lipopeptide-2 cooperates with IFN-gamma to reverse the Th2 skew in an in vitro allergy model.
Authors: Weigt H, Muhlradt PF, Larbig M, Krug N, Braun A
J. Immunol., 2004;172(10):6080-6.
Species: Human
Sample Type: Cell Culture Supernates

Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors.
Authors: Cloez-Tayarani I, Petit-Bertron AF, Venters HD, Cavaillon JM
Int. Immunol., 2003;15(2):233-40.
Species: Human
Sample Type: Cell Culture Supernates

背景Interleukin-10 functions as an anti-inflammatory cytokine by inhibiting the expansion and activation of Th1 cells and Th17 cells and by promoting the development of M2 macrophages and regulatory T cells (Treg). Within a tumor microrenvironment, however, IL-10 can inhibit the expansion of both Treg and myeloid-derived suppressor cells (MDSC). IL-10 exerts protective effects including limiting tissue damage in arthritic inflammation and promoting muscle regeneration after injury, but it also contributes to the persistence of viral infections. IL-10 signals through a receptor complex composed of IL-10 R alpha and IL-10 R beta. IL-10 R beta additionally associates with IL-20 R alpha, IL-22 R alpha 1, or IL-28 R alpha to form the receptor complexes for IL-22, IL-26, IL-28, and IL-29.
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