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Human IL-6 DuoSet ELISA, 5 Plate (1 KT)

货号: DY206-05 基本售价: 3882.5 元 规格: 1 KIT

产品信息

概述
货号DY206-05
别名
B cell stimulatory factor-2; B-cell differentiation factor; BSF-2; BSF2CTL differentiation factor; CDF; HGFHSFIFNB2Hybridoma growth factor; IFN-beta-2; IL6; IL-6; IL-6B-cell stimulatory factor 2; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A
全称Interleukin 6
反应种属Human
目标/特异性Please see the product datasheet
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 100034196 (Equine); 493687 (Feline); 100008733 (Rabbit);
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Characterization of the MMP/TIMP Imbalance and Collagen Production Induced by IL-1? or TNF-? Release from Human Hepatic Stellate Cells
Authors: S Robert, T Gicquel, A Bodin, V Lagente, E Boichot
PLoS ONE, 2016;11(4):e0153118.
Species: Human
Sample Type: Cell Culture Supernates

Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium
PLoS ONE, 2016;11(5):e0155161.
Species: Human
Sample Type: Cell Culture Supernates

Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients
Int J Mol Sci, 2016;17(5):.
Species: Human
Sample Type: Plasma

Analysis of receptor tyrosine kinase genetics identifies two novel risk loci in GAS6 and PROS1 in Beh�et's disease
Sci Rep, 2016;6(0):26662.
Species: Human
Sample Type: Cell Culture Supernates

Graphene-augmented nanofiber scaffolds demonstrate new features in cells behaviour
Sci Rep, 2016;6(0):30150.
Species: Human
Sample Type: Cell Culture Supernates

Acanthamoeba castellanii (Genotype T4) Stimulates the Production of Interleukin-10 as well as Pro-inflammatory Cytokines in THP-1 Cells, Human Peripheral Blood Mononuclear Cells and Human Monocyte-Derived Macrophages
Infect Immun, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion
Authors: Mélissa Noack
Arthritis Res Ther, 2016;18(0):148.
Species: Human
Sample Type: Cell Culture Supernates

IL-17 Promotes Neutrophil-Mediated Immunity by Activating Microvascular Pericytes and Not Endothelium
J Immunol, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Engineering a 3D microfluidic culture platform for tumor-treating field application
Sci Rep, 2016;6(0):26584.
Species: Human
Sample Type: Cell Culture Supernates

DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum
J Immunol, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Dual Inhibition of Rip2 and IRAK1/4 Regulates IL-1? and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear Cells
J Immunol, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin
J Immunol, 2016;196(11):4681-91.
Species: Human
Sample Type: Cell Culture Supernates

Genetic polymorphisms of cell adhesion molecules in Behcet's disease in a Chinese Han population
Authors: M Zheng, L Zhang, H Yu, J Hu, Q Cao, G Huang, Y Huang, G Yuan, A Kijlstra, P Yang
Sci Rep, 2016;6(0):24974.
Species: Human
Sample Type: Cell Culture Supernates

In vitro progesterone modulation on bacterial endotoxin-induced production of IL-1beta, TNFalpha, IL-6, IL-8, IL-10, MIP-1alpha, and MMP-9 in pre-labor human term placenta.
Authors: Garcia-Ruiz G, Flores-Espinosa P, Preciado-Martinez E, Bermejo-Martinez L, Espejel-Nunez A, Estrada-Gutierrez G, Maida-Claros R, Flores-Pliego A, Zaga-Clavellina V
Reprod Biol Endocrinol, 2015;13(0):115.
Species: Human
Sample Type: Cell Culture Supernates

Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells.
Authors: Price L, Shao D, Meng C, Perros F, Garfield B, Zhu J, Montani D, Dorfmuller P, Humbert M, Adcock I, Wort S
Respir Res, 2015;16(0):114.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin-23 Receptor Gene Polymorphism May Enhance Expression of the IL-23 Receptor, IL-17, TNF-alpha and IL-6 in Behcet's Disease.
Authors: Jiang Z, Hennein L, Tao Y, Tao L
PLoS ONE, 2015;10(7):e0134632.
Species: Human
Sample Type: Cell Culture Supernates

Transcriptomic Analyses of the Biological Effects of Airborne PM2.5 Exposure on Human Bronchial Epithelial Cells.
Authors: Zhou Z, Liu Y, Duan F, Qin M, Wu F, Sheng W, Yang L, Liu J, He K
PLoS ONE, 2015;10(9):e0138267.
Species: Human
Sample Type: Cell Culture Supernates

BET bromodomains regulate transforming growth factor-beta-induced proliferation and cytokine release in asthmatic airway smooth muscle.
Authors: Perry M, Durham A, Austin P, Adcock I, Chung K
J Biol Chem, 2015;290(14):9111-21.
Species: Human
Sample Type: Cell Culture Supernates

Effect of lipopolysaccharide on glucocorticoid receptor function in control nasal mucosa fibroblasts and in fibroblasts from patients with chronic rhinosinusitis with nasal polyps and asthma.
Authors: Fernandez-Bertolin L, Mullol J, Fuentes-Prado M, Roca-Ferrer J, Alobid I, Picado C, Pujols L
PLoS ONE, 2015;10(5):e0125443.
Species: Human
Sample Type: Cell Culture Supernates

The effects of knockdown of rho-associated kinase 1 and zipper-interacting protein kinase on gene expression and function in cultured human arterial smooth muscle cells.
Authors: Deng J, Wang X, Chen Y, OBrien E, Gui Y, Walsh M
PLoS ONE, 2015;10(2):e0116969.
Species: Human
Sample Type: Cell Culture Supernates

High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus.
Authors: Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, Konig R, Becker S, Waibler Z, Muhlebach M
J Virol, 2015;89(7):3859-69.
Species: Human
Sample Type: Cell Culture Supernates

Cytosolic phospholipase A2 modulates TLR2 signaling in synoviocytes.
Authors: Sommerfelt R, Feuerherm A, Skuland T, Johansen B
PLoS ONE, 2015;10(4):e0119088.
Species: Human
Sample Type: cell supernates

Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.
Authors: Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C
Respir Res, 2015;16(0):14.
Species: Human
Sample Type: Cell Culture Supernates

Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production.
Authors: Kearney C, Cullen S, Tynan G, Henry C, Clancy D, Lavelle E, Martin S
Cell Death Differ, 2015;22(8):1313-27.
Species: Human
Sample Type: Cell Culture Supernates

Exposure to diesel exhaust particle extracts (DEPe) impairs some polarization markers and functions of human macrophages through activation of AhR and Nrf2.
Authors: Jaguin M, Fardel O, Lecureur V
PLoS ONE, 2015;10(2):e0116560.
Species: Human
Sample Type: Cell Culture Supernates

An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells.
Authors: Campia I, Buondonno I, Castella B, Rolando B, Kopecka J, Gazzano E, Ghigo D, Riganti C
PLoS ONE, 2015;10(5):e0126159.
Species: Human
Sample Type: Cell Culture Supernates

LPS-Stimulated Whole Blood Cytokine Production Is Not Related to Disease Behavior in Patients with Quiescent Crohn's Disease.
Authors: Broekman M, Roelofs H, Hoentjen F, Wiegertjes R, Stoel N, Joosten L, de Jong D, Wanten G
PLoS ONE, 2015;10(7):e0133932.
Species: Human
Sample Type: Plasma

TRAF5 and TRAF3IP2 gene polymorphisms are associated with Behcet's disease and Vogt-Koyanagi-Harada syndrome: a case-control study.
Authors: Xiang Q, Chen L, Hou S, Fang J, Zhou Y, Bai L, Liu Y, Kijlstra A, Yang P
PLoS ONE, 2014;9(1):e84214.
Species: Human
Sample Type: Cell Culture Supernates

Circulating autoantibodies to endothelial progenitor cells: binding characteristics and association with risk factors for atherosclerosis.
Authors: George J, Matucci-Cerinic M, Bar I, Shimoni S
PLoS ONE, 2014;9(6):e97836.
Species: Human
Sample Type: Serum

Role of non-coding RNAs in maintaining primary airway smooth muscle cells.
Authors: Perry, Mark M, Tsitsiou, Eleni, Austin, Philip J, Lindsay, Mark A, Gibeon, David S, Adcock, Ian M, Chung, Kian Fan
Respir Res, 2014;15(0):58.
Species: Human
Sample Type: Cell Culture Supernates

Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes.
Authors: Dreymueller D, Martin C, Schumacher J, Groth E, Boehm J, Reiss L, Uhlig S, Ludwig A
J Immunol, 2014;192(2):722-31.
Species: Human
Sample Type: Cell Culture Supernates

Optofluidic laser for dual-mode sensitive biomolecular detection with a large dynamic range.
Authors: Wu X, Oo M, Reddy K, Chen Q, Sun Y, Fan X
Nat Commun, 2014;5(0):3779.
Species: Human
Sample Type: protein

RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.
Authors: Rigby R, Webb L, Mackenzie K, Li Y, Leitch A, Reijns M, Lundie R, Revuelta A, Davidson D, Diebold S, Modis Y, MacDonald A, Jackson A
EMBO J, 2014;33(6):542-58.
Species: Human
Sample Type: cell supernates

Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.
Authors: Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J, Cirstea D, Gorgun G, Minami J, Tai Y, Richardson P, Utsugi T, Iwama A, Anderson K
Cancer Res, 2014;74(16):4458-69.
Species: Human
Sample Type: Cell Culture Supernates

Association of TLR2 gene polymorphisms with ocular Behcet's disease in a Chinese Han population.
Authors: Fang J, Hu R, Hou S, Ye Z, Xiang Q, Qi J, Zhou Y, Kijlstra A, Yang P
Invest Ophthalmol Vis Sci, 2013;54(13):8384-92.
Species: Human
Sample Type: Cell Culture Supernates

Ex vivo cytokine release and pattern recognition receptor expression of subjects exposed to dampness: pilot study to assess the outcome of mould exposure to the innate immune system.
Authors: Punsmann S, Liebers V, Lotz A, Bruning T, Raulf M
PLoS ONE, 2013;8(12):e82734.
Species: Human
Sample Type: Serum

Effects of high-dose cholecalciferol on serum markers of inflammation and immunity in patients with early chronic kidney disease.
Authors: Alvarez J, Zughaier S, Law J, Hao L, Wasse H, Ziegler T, Tangpricha V
Eur J Clin Nutr, 2013;67(3):264-9.
Species: Human
Sample Type: Serum

Human cytomegalovirus induces a biphasic inflammatory response in primary endothelial cells.
Authors: Jeffery H, Soderberg-Naucler C, Butler L
J Virol, 2013;87(11):6530-5.
Species: Human
Sample Type: cell culture supernate

Selective activation of human dendritic cells by OM-85 through a NF-kB and MAPK dependent pathway.
Authors: Parola C, Salogni L, Vaira X, Scutera S, Somma P, Salvi V, Musso T, Tabbia G, Bardessono M, Pasquali C, Mantovani A, Sozzani S, Bosisio D
PLoS ONE, 2013;8(12):e82867.
Species: Human
Sample Type: cell culture supernate

Decidual natural killer cell interactions with trophoblasts are impaired in pregnancies at increased risk of preeclampsia.
Authors: Wallace A, Host A, Whitley G, Cartwright J
Am J Pathol, 2013;183(6):1853-61.
Species: Human
Sample Type: cell culture supernate

Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion.
Authors: Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, Nutman T, Semnani R
Infect Immun, 2013;81(5):1420-9.
Species: Human
Sample Type: Cell Culture Supernates

Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti.
Authors: Arndts K, Deininger S, Specht S, Klarmann U, Mand S, Adjobimey T, Debrah AY, Batsa L, Kwarteng A, Epp C, Taylor M, Adjei O, Layland LE, Hoerauf A
PLoS Negl Trop Dis, 2012;6(4):e1611.
Species: Human
Sample Type: Cell Culture Supernates

Transglutaminase is essential for IgA nephropathy development acting through IgA receptors.
Authors: Berthelot L, Papista C, Maciel TT, Biarnes-Pelicot M, Tissandie E, Wang PH, Tamouza H, Jamin A, Bex-Coudrat J, Gestin A, Boumediene A, Arcos-Fajardo M, England P, Pillebout E, Walker F, Daugas E, Vrtosvnik F, Flamant M, Benhamou M, Cogne M, Moura IC, Monteiro RC
J. Exp. Med., 2012;209(4):793-806.
Species: Human
Sample Type: Cell Culture Supernates

Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:C.
Authors: Drannik AG, Nag K, Yao XD, Henrick BM, Sallenave JM, Rosenthal KL
PLoS ONE, 2012;7(4):e35866.
Species: Human
Sample Type: Cell Culture Supernates

IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist.
Authors: van de Veerdonk FL, Stoeckman AK, Wu G, Boeckermann AN, Azam T, Netea MG, Joosten LA, Van der Meer JW, Hao R, Kalabokis V, Dinarello CA
Proc. Natl. Acad. Sci. U.S.A., 2012;109(8):3001-5.
Species: Human
Sample Type: Cell Culture Supernates

Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).
Authors: Suh HS, Choi N, Tarassishin L, Lee SC
PLoS ONE, 2012;7(4):e35115.
Species: Human
Sample Type: Cell Culture Supernates

Characterization and function of the human macrophage dopaminergic system: implications for CNS disease and drug abuse.
J Neuroinflammation, 2012;9(0):203.
Species: Human
Sample Type: Cell Culture Supernates

Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
Authors: Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS
PLoS ONE, 2012;7(4):e34965.
Species: Human
Sample Type: Cell Culture Supernates

ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes.
Authors: Wilhelmsen K, Mesa K, Lucero J, Xu F, Hellman J
J Biol Chem, 2012;287(32):26478-94.
Species: Human
Sample Type: Cell Culture Supernates

Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation.
Eur J Clin Nutr, 2012;66(9):1072-4.
Species: Human
Sample Type: Plasma

Inhibition of IL-32 activation by alpha-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.
Authors: Marcondes AM, Li X, Tabellini L, Bartenstein M, Kabacka J, Sale GE, Hansen JA, Dinarello CA, Deeg HJ
Blood, 2011;118(18):5031-9.
Species: Human
Sample Type: Cell Culture Supernates

GLI2 Transcription Factor Mediates Cytokine Cross-talk in the Tumor Microenvironment.
Authors: Elsawa SF, Almada LL, Ziesmer SC, Novak AJ, Witzig TE, Ansell SM, Fernandez-Zapico ME
J. Biol. Chem., 2011;286(24):21524-34.
Species: Human
Sample Type: Cell Culture Supernates

IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes.
Authors: Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, Garcovich S, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Immunol., 2010;184(9):4880-8.
Species: Human
Sample Type: Cell Culture Supernates

Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6.
Authors: Eikawa S, Ohue Y, Kitaoka K
J. Immunol., 2010;185(11):6734-40.
Species: Human
Sample Type: Plueral Effusion

PI3K/p110{delta} is a novel therapeutic target in multiple myeloma.
Authors: Ikeda H, Hideshima T, Fulciniti M
Blood, 2010;116(9):1460-8.
Species: Human
Sample Type: Cell Culture Supernates

Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease.
Authors: Khankin EV, Mutter WP, Tamez H
PLoS ONE, 2010;5(2):e9246.
Species: Human
Sample Type: Serum

Carbon dioxide inhalation causes pulmonary inflammation.
Authors: Abolhassani M, Guais A, Chaumet-Riffaud P, Sasco AJ, Schwartz L
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(4):L657-65.
Species: Human
Sample Type: Cell Culture Supernates

Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men.
Authors: Damsgaard CT, Lauritzen L, Calder PC, Kjaer TR, Frokiaer H
J. Nutr., 2009;139(7):1410-4.
Species: Human
Sample Type: Cell Culture Supernates

Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1.
Authors: Christophi GP, Panos M, Hudson CA, Tsikkou C, Mihai C, Mejico LJ, Jubelt B, Massa PT
Clin. Immunol., 2009;133(1):27-44.
Species: Human
Sample Type: Plasma

Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.
Authors: Hawn TR, Scholes D, Wang H, Li SS, Stapleton AE, Janer M, Aderem A, Stamm WE, Zhao LP, Hooton TM
PLoS ONE, 2009;4(12):e8300.
Species: Human
Sample Type: Urine

Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms.
Authors: Correale J, Farez M
J. Immunol., 2009;183(9):5999-6012.
Species: Human
Sample Type: Cell Culture Supernates

Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling.
Authors: Huang QQ, Sobkoviak R, Jockheck-Clark AR, Shi B, Mandelin AM, Tak PP, Haines GK, Nicchitta CV, Pope RM
J. Immunol., 2009;182(8):4965-73.
Species: Human
Sample Type: Cell Culture Supernates

Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells.
Authors: Hao Q, Wang L, Tang H
Am. J. Physiol., Cell Physiol., 2009;296(4):C821-7.
Species: Human
Sample Type: Cell Culture Supernates

Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
Authors: Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, Orinska Z, Paus R, Bulfone-Paus S, Giovarelli M
J. Immunol., 2009;183(5):3004-13.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.
Authors: Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G
Circulation, 2009;119(10):1424-32.
Species: Human
Sample Type: Plasma

TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.
Authors: Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M
Eur. J. Immunol., 2009;39(5):1221-30.
Species: Human
Sample Type: Cell Culture Supernates

Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12.
Authors: Lamhamedi-Cherradi SE, Martin RE, Ito T, Kheradmand F, Corry DB, Liu YJ, Moyle M
J. Immunol., 2008;180(9):6000-9.
Species: Human
Sample Type: Cell Culture Supernates

Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia.
Authors: Zhao S, Gu Y, Dong Q, Fan R, Wang Y
Placenta, 2008;29(12):1024-8.
Species: Human
Sample Type: Cell Culture Supernates

Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma.
Authors: Breitkreutz I, Raab MS, Vallet S, Hideshima T, Raje N, Mitsiades C, Chauhan D, Okawa Y, Munshi NC, Richardson PG, Anderson KC
Leukemia, 2008;22(10):1925-32.
Species: Human
Sample Type: Cell Culture Supernates

Adenosine receptors in regulation of dendritic cell differentiation and function.
Authors: Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM
Blood, 2008;112(5):1822-31.
Species: Human
Sample Type: Cell Culture Supernates

Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production.
Authors: Ahmed S, Marotte H, Kwan K, Ruth JH, Campbell PL, Rabquer BJ, Pakozdi A, Koch AE
Proc. Natl. Acad. Sci. U.S.A., 2008;105(38):14692-7.
Species: Human
Sample Type: Tissue Homogenates

Helminth infections associated with multiple sclerosis induce regulatory B cells.
Authors: Correale J, Farez M, Razzitte G
Ann. Neurol., 2008;64(2):187-99.
Species: Human
Sample Type: Cell Culture Supernates

Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages.
Authors: Birrell MA, Wong S, Catley MC, Belvisi MG
J. Cell. Physiol., 2008;214(1):27-37.
Species: Human
Sample Type: Cell Culture Supernates

Reduced response to adiponectin and lower abundance of adiponectin receptor proteins in type 2 diabetic monocytes.
Authors: Weigert J, Neumeier M, Wanninger J, Wurm S, Kopp A, Schober F, Filarsky M, Schaffler A, Zeitoun M, Aslanidis C, Buechler C
FEBS Lett., 2008;582(12):1777-82.
Species: Human
Sample Type: Cell Culture Supernates

p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications.
Authors: Ishitsuka K, Hideshima T, Neri P, Vallet S, Shiraishi N, Okawa Y, Shen Z, Raje N, Kiziltepe T, Ocio EM, Chauhan D, Tassone P, Munshi N, Campbell RM, Dios AD, Shih C, Starling JJ, Tamura K, Anderson KC
Br. J. Haematol., 2008;141(5):598-606.
Species: Human
Sample Type: Cell Culture Supernates

Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses.
Authors: Birrell MA, Catley MC, Hardaker E, Wong S, Willson TM, McCluskie K, Leonard T, Farrow SN, Collins JL, Haj-Yahia S, Belvisi MG
J. Biol. Chem., 2007;282(44):31882-90.
Species: Human
Sample Type: Cell Culture Supernates

Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis.
Authors: Wu T, Xie C, Wang HW, Zhou XJ, Schwartz N, Calixto S, Mackay M, Aranow C, Putterman C, Mohan C
J. Immunol., 2007;179(10):7166-75.
Species: Human
Sample Type: Urine

Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma.
Authors: Breitkreutz I, Raab MS, Vallet S, Hideshima T, Raje N, Chauhan D, Munshi NC, Richardson PG, Anderson KC
Br. J. Haematol., 2007;139(1):55-63.
Species: Human
Sample Type: Cell Culture Supernates

Early cytokine responses after percutaneous magnetic resonance imaging guided laser thermoablation of malignant liver tumors.
Authors: Kallio R, Sequeiros R, Surcel HM, Ohtonen P, Kiviniemi H, Syrjala H
Cytokine, 2007;34(5):278-83.
Species: Human
Sample Type: Serum

Preadipocyte response and impairment of differentiation in an inflammatory environment.
Authors: Poulain-Godefroy O, Froguel P
Biochem. Biophys. Res. Commun., 2007;356(3):662-7.
Species: Human
Sample Type: Cell Culture Supernates

Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling.
Authors: Weindl G, Naglik JR, Kaesler S, Biedermann T, Hube B, Korting HC, Schaller M
J. Clin. Invest., 2007;117(12):3664-3672.
Species: Human
Sample Type: Cell Culture Supernates

Cytokine response to strenuous exercise in athletes and non-athletes--an adaptive response.
Authors: Gokhale R, Chandrashekara S, Vasanthakumar KC
Cytokine, 2007;40(2):123-7.
Species: Human
Sample Type: Plasma

Influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells.
Authors: Aydin S, Signorelli S, Lechleitner T, Joannidis M, Pleban C, Perco P, Pfaller W, Jennings P
Am. J. Physiol., Cell Physiol., 2007;294(2):C543-54.
Species: Human
Sample Type: Cell Culture Supernates

Role of matrix metalloproteinases in the inflammatory response in human airway cell-based assays and in rodent models of airway disease.
Authors: Birrell MA, Wong S, Dekkak A, De Alba J, Haj-Yahia S, Belvisi MG
J. Pharmacol. Exp. Ther., 2006;318(2):741-50.
Species: Human
Sample Type: Cell Culture Supernates

A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression.
Authors: Macagno A, Molteni M, Rinaldi A
J. Exp. Med., 2006;203(6):1481-92.
Species: Human
Sample Type: Cell Culture Supernates

Comparison of serum levels of inflammatory markers in patients with coronary vasospasm without significant fixed coronary artery disease versus patients with stable angina pectoris and acute coronary syndromes with significant fixed coronary artery disease.
Authors: Hung MJ, Cherng WJ, Cheng CW, Li LF
Am. J. Cardiol., 2006;97(10):1429-34.
Species: Human
Sample Type: Serum

The effects of dexamethasone and dehydroepiandrosterone (DHEA) on cytokines and receptor expression in a human osteoblastic cell line: potential steroid-sparing role for DHEA.
Authors: Harding G, Mak YT, Evans B, Cheung J, MacDonald D, Hampson G
Cytokine, 2006;36(1):57-68.
Species: Human
Sample Type: Cell Culture Supernates

TLR3 can directly trigger apoptosis in human cancer cells.
Authors: Salaun B, Coste I, Rissoan MC, Lebecque SJ, Renno T
J. Immunol., 2006;176(8):4894-901.
Species: Human
Sample Type: Cell Culture Supernates

ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin.
Authors: Karadag A, Zhou M, Croucher PI
Blood, 2006;107(8):3271-8.
Species: Human
Sample Type: Cell Culture Supernates

Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk.
Authors: LeBouder E, Rey-Nores JE, Raby AC, Affolter M, Vidal K, Thornton CA, Labeta MO
J. Immunol., 2006;176(6):3742-52.
Species: Human
Sample Type: Cell Culture Supernates

Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1).
Authors: Palmer G, Trolliet S, Talabot-Ayer D, Mezin F, Magne D, Gabay C
Cytokine, 2005;31(2):153-60.
Species: Human
Sample Type: Cell Culture Supernates

Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists.
Authors: Fritz JH, Girardin SE, Fitting C, Werts C, Mengin-Lecreulx D, Caroff M, Cavaillon JM, Philpott DJ, Adib-Conquy M
Eur. J. Immunol., 2005;35(8):2459-70.
Species: Human
Sample Type: Cell Culture Supernates

Microbial exposure, symptoms and inflammatory mediators in nasal lavage fluid of kitchen and clerical personnel in schools.
Authors: Lignell U, Meklin T, Putus T, Vepsalainen A, Roponen M, Torvinen E, Reeslev M, Pennanen S, Hirvonen MR, Kalliokoski P, Nevalainen A
Int J Occup Med Environ Health, 2005;18(2):139-50.
Species: Human
Sample Type: nasal lavage

IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate.
Authors: Miranda-Carus ME, Balsa A, Benito-Miguel M, Perez de Ayala C, Martin-Mola E
J. Immunol., 2004;173(2):1463-76.
Species: Human
Sample Type: Cell Culture Supernates

Biocompatibility pattern of a bicarbonate/lactate-buffered peritoneal dialysis fluid in APD: a prospective, randomized study.
Authors: Fusshoeller A, Plail M, Grabensee B, Plum J
Nephrol. Dial. Transplant., 2004;19(8):2101-6.
Species: Human
Sample Type: Peritoneal Dialysate

IL-1, IL-6 and TNF-alpha concentrations in the peritoneal fluid of women with pelvic adhesions.
Authors: Cheong YC, Shelton JB, Laird SM, Richmond M, Kudesia G, Li TC, Ledger WL
Hum. Reprod., 2002;17(1):69-75.
Species: Human
Sample Type: Peritoneal Fluid

The correlation of adhesions and peritoneal fluid cytokine concentrations: a pilot study.
Authors: Cheong YC, Laird SM, Shelton JB, Ledger WL, Li TC, Cooke ID
Hum. Reprod., 2002;17(4):1039-45.
Species: Human
Sample Type: Peritoneal Fluid

Comparison of inflammatory elements in nasal lavage and induced sputum following occupational exposure to moldy-building microbes.
Authors: Purokivi M, Hirvonen MR, Roponen M, Randell J, Vahteristo M, Tukiainen H
Inhal Toxicol, 2002;14(6):653-62.
Species: Human
Sample Type: Sputum

Inflammatory mediators in nasal lavage, induced sputum and serum of employees with rheumatic and respiratory disorders.
Authors: Roponen M, Kiviranta J, Seuri M, Tukiainen H, Myllykangas-Luosujarvi R, Hirvonen MR
Eur. Respir. J., 2001;18(3):542-8.
Species: Human
Sample Type: Serum

Reproducibility of measurements of exhaled NO, and cell count and cytokine concentrations in induced sputum.
Authors: Purokivi M, Randell J, Hirvonen MR, Tukiainen H
Eur. Respir. J., 2000;16(2):242-6.
Species: Human
Sample Type: Sputum

Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients.
Authors: Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S
Mucosal Immunol, 0;5(2):140-9.
Species: Human
Sample Type: Cell Culture Supernates

背景IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. It contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 signals through a receptor complex of IL-6 R alpha and gp130. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha.
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