R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Interleukin-33 from Monocytes Recruited to the Lung Contributes to House Dust Mite-Induced Airway Inflammation in a Mouse Model Authors: Hiroki Tashiro PLoS ONE, 2016;11(6):e0157571. Species: Mouse Sample Type: Whole Tissue Application: IHC - Paraffin embedded Expression and function of IL-1R8 (TIR8/SIGIRR), a regulatory member of the IL-1 receptor family in platelets Authors: Achille Anselmo Cardiovasc Res, 2016;0(0):. Species: Human Sample Type: Whole Cells Application: Flow Ctrl Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate Clin Cancer Res, 2016;0(0):. Species: Mouse Sample Type: In Vivo Application: In vivo Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway. Authors: Liu T, Kanaoka Y, Barrett N, Feng C, Garofalo D, Lai J, Buchheit K, Bhattacharya N, Laidlaw T, Katz H, Boyce J J Immunol, 2016;195(8):3537-45. Species: Mouse Sample Type: In Vivo Application: In vivo Collagen-induced arthritis and imiquimod-induced psoriasis develop independently of interleukin-33 Authors: Sara Khaleghparast Athari Arthritis Res Ther, 2016;18(1):143. Species: Mouse Sample Type: Whole Tissue Application: IHC - Paraffin embedded The Effect of Chronic Hepatitis B Virus Infection on BDCA3+ Dendritic Cell Frequency and Function PLoS ONE, 2016;11(8):e0161235. Species: Human Sample Type: Whole Cells Application: Bioassay The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation Authors: C Cerri, S Genovesi, M Allegra, F Pistillo, U Püntener, A Guglielmot, VH Perry, Y Bozzi, M Caleo J Neurosci, 2016;36(13):3777-88. Species: Mouse Sample Type: In Vivo Application: In vivo A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo. Authors: Wong J, Krueger K, Costa M, Aggarwal A, Du H, McLaughlin T, Feldman B Sci Signal, 2016;9(451):ra103. Species: Mouse Sample Type: In Vivo Application: Bioassay HEREGULIN/ErbB3 SIGNALING ENHANCES CXCR4-DRIVEN Rac1 ACTIVATION AND BREAST CANCER CELL MOTILITY VIA HIF-1? Mol Cell Biol, 2016;0(0):. Species: Human Sample Type: Chromatin Application: ChIP Assay IL-1alpha signaling is critical for leukocyte recruitment after pulmonary Aspergillus fumigatus challenge. Authors: Caffrey A, Lehmann M, Zickovich J, Espinosa V, Shepardson K, Watschke C, Hilmer K, Thammahong A, Barker B, Rivera A, Cramer R, Obar J PLoS Pathog, 2015;11(1):e1004625. Species: Mouse Sample Type: In Vivo Application: In vivo IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells. Authors: Crosley, Erin J, Dunk, Caroline, Beristain, Alexande, Christians, Julian K Reprod Biol Endocrinol, 2015;12(0):123. Species: Human Sample Type: Whole Tissue Application: IHC Ctrl The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity. Authors: Hoffmann F, Kuhn P, Laurent S, Hauck S, Berer K, Wendlinger S, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister H, Alexander T, Hiepe F, Kumpfel T, Crawford H, Wekerle H, Hohlfeld R, Lichtenthaler S, Meinl E J Immunol, 2015;194(2):542-52. Species: Human Sample Type: cell culture supernate Application: IP Stearoyl-CoA desaturase 1 and paracrine diffusible signals have a major role in the promotion of breast cancer cell migration induced by cancer-associated fibroblasts. Authors: Angelucci C, Maulucci G, Colabianchi A, Iacopino F, DAlessio A, Maiorana A, Palmieri V, Papi M, De Spirito M, Di Leone A, Masetti R, Sica G Br J Cancer, 2015;112(10):1675-86. Species: Human Sample Type: Whole Cells Application: Neut Ctrl High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus. Authors: Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, Konig R, Becker S, Waibler Z, Muhlebach M J Virol, 2015;89(7):3859-69. Species: Human Sample Type: Whole Cells Application: Ctrl Crucial role of IL1beta and C3a in the in vitro-response of multipotent mesenchymal stromal cells to inflammatory mediators of polytrauma. Authors: Hengartner N, Fiedler J, Schrezenmeier H, Huber-Lang M, Brenner R PLoS ONE, 2015;10(1):e0116772. Species: Human Sample Type: Whole Cells Application: Blocking The Tissue Fibrinolytic System Contributes to the Induction of Macrophage Function and CCL3 during Bone Repair in Mice. Authors: Kawao N, Tamura Y, Horiuchi Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H PLoS ONE, 2015;10(4):e0123982. Species: Mouse Sample Type: In Vivo Application: In vivo Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Authors: Bonapace L, Coissieux M, Wyckoff J, Mertz K, Varga Z, Junt T, Bentires-Alj M Nature, 2015;515(7525):130-3. Species: Mouse Sample Type: In Vivo
Convergence of cMyc and beta-catenin on Tcf7l1 enables endoderm specification. Authors: Morrison G, Scognamiglio R, Trumpp A, Smith A EMBO J, 2015;35(3):356-68. Species: Mouse Sample Type: Cell Lysates Application: ChIP An anti-inflammatory property of Candida albicans beta-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism. Authors: Smeekens S, Gresnigt M, Becker K, Cheng S, Netea S, Jacobs L, Jansen T, van de Veerdonk F, Williams D, Joosten L, Dinarello C, Netea M Cytokine, 2015;71(2):215-22. Species: Human Sample Type: Whole Cells Application: Neut Ctrl Survival of neural stem cell grafts in the lesioned spinal cord is enhanced by a combination of treadmill locomotor training via insulin-like growth factor-1 signaling. Authors: Hwang D, Shin H, Kwon M, Choi J, Ryu B, Kim B J Neurosci, 2014;34(38):12788-800. Species: Rat Sample Type: In Vivo Application: In Vivo Lymphotoxin beta receptor signaling induces IL-8 production in human bronchial epithelial cells. Authors: Mikami Y, Matsuzaki H, Horie M, Noguchi S, Jo T, Narumoto O, Kohyama T, Takizawa H, Nagase T, Yamauchi Y PLoS ONE, 2014;9(12):e114791. Species: Human Sample Type: Cell Lysate Application: Isotype control Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7. Authors: Su, Boxing, Zhao, Wei, Shi, Bentao, Zhang, Zhongyua, Yu, Xi, Xie, Feng, Guo, Zhongqia, Zhang, Xiaoyu, Liu, Jin, Shen, Qi, Wang, Jinghua, Li, Xuesong, Zhang, Zhiqian, Zhou, Liqun Mol Cancer, 2014;13(0):206. Species: Human Sample Type: Whole Cells Application: Neut Ctrl Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Authors: Ramkhelawon B, Hennessy E, Menager M, Ray T, Sheedy F, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner K, Moore K Nat Med, 2014;20(4):377-84. Species: Mouse Sample Type: Whole Cells Application: Bioassay - Ctrl Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta. Authors: Zhao Y, Xiao X, Frank S, Lin H, Xia Y Am J Physiol Endocrinol Metab, 2014;307(2):E186-98. Species: Mouse Sample Type: In Vivo Application: In vivo Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone. Authors: Shigemoto-Mogami Y, Hoshikawa K, Goldman J, Sekino Y, Sato K J Neurosci, 2014;34(6):2231-43. Species: Rat Sample Type: Whole Cells Application: Neut Quantitative analyses of retinal vascular area and density after different methods to reduce VEGF in a rat model of retinopathy of prematurity. Authors: Wang H, Yang Z, Jiang Y, Flannery J, Hammond S, Kafri T, Vemuri S, Jones B, Hartnett M Invest Ophthalmol Vis Sci, 2014;55(2):737-44. Species: Rat Sample Type: In Vivo Application: contorl NF-kappaB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma. Authors: McFarland B, Hong S, Rajbhandari R, Twitty G, Gray G, Yu H, Benveniste E, Nozell S PLoS ONE, 2013;8(11):e78728. Application: Isotype control Fetal fibronectin signaling induces matrix metalloproteases and cyclooxygenase-2 (COX-2) in amnion cells and preterm birth in mice. Authors: Mogami H, Kishore A, Shi H, Keller P, Akgul Y, Word R J Biol Chem, 2013;288(3):1953-66. Species: Human Sample Type: whole cells Application: Neut Ctrl Lenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphoma. Authors: Song K, Herzog B, Sheng M, Fu J, McDaniel J, Chen H, Ruan J, Xia L Cancer Res, 2013;73(24):7254-64. Species: Mouse Sample Type: Whole Cells Application: Neut Ctrl CCR6 is required for epidermal trafficking of gammadelta-T cells in an IL-23-induced model of psoriasiform dermatitis. Authors: Mabuchi T, Singh T, Takekoshi T, Jia G, Wu X, Kao M, Weiss I, Farber J, Hwang S J Invest Dermatol, 2013;133(1):164-71. Species: Mouse Sample Type: tissue Application: IHC Frozen Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. Authors: Yang, Guang, Holl, T Matt, Liu, Yang, Li, Yi, Lu, Xiaozhi, Nicely, Nathan I, Kepler, Thomas B, Alam, S Munir, Liao, Hua-Xin, Cain, Derek W, Spicer, Leonard, VandeBerg, John L, Haynes, Barton F, Kelsoe, Garnett J Exp Med, 2013;210(2):241-56. Species: Human Sample Type: whole cells Application: IF Tricyclic antidepressant amitriptyline indirectly increases the proliferation of adult dentate gyrus-derived neural precursors: an involvement of astrocytes. Authors: Boku, Shuken, Hisaoka-Nakashima, Kazue, Nakagawa, Shin, Kato, Akiko, Kajitani, Naoto, Inoue, Takeshi, Kusumi, Ichiro, Takebayashi, Minoru PLoS ONE, 2013;8(11):e79371. Species: Rat Sample Type: whole cells Application: Neut Ctrl Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence. Authors: Brzezinski J, Uoon Park K, Reh T Dev Biol, 2013;384(2):194-204. Species: Mouse Sample Type: Tissue Homogenates Application: IP Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function. Authors: Langer, Marybeth, Duggan, Elizabet, Booth, John Lel, Patel, Vineet I, Zander, Ryan A, Silasi-Mansat, Robert, Ramani, Vijay, Veres, Tibor Zo, Prenzler, Frauke, Sewald, Katherin, Williams, Daniel M, Coggeshall, Kenneth, Awasthi, Shanjana, Lupu, Florea, Burian, Dennis, Ballard, Jimmy Da, Braun, Armin, Metcalf, Jordan P Infect Immun, 2012;80(12):4374-87. Species: Human Sample Type: Whole Cells Application: Ctrl Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis. J. Clin. Invest., 2012;122(9):3184-96. Species: Mouse Sample Type: In Vivo Application: In vivo control Galectin-8 Promotes Cytoskeletal Rearrangement in Trabecular Meshwork Cells through Activation of Rho Signaling. Authors: Diskin S, Chen WS, Cao Z, Gyawali S, Gong H, Soza A, Gonzalez A, Panjwani N PLoS ONE, 2012;7(9):e44400. Species: Human Sample Type: Whole Tissue Application: Ctrl Transforming growth factor Beta 3 is required for excisional wound repair in vivo. Authors: Le M, Naridze R, Morrison J, Biggs L, Rhea L, Schutte B, Kaartinen V, Dunnwald M PLoS ONE, 2012;7(10):e48040. Species: Mouse Sample Type: In Vivo Application: Ctrl Leukemia inhibitory factor signaling is required for lung protection during pneumonia. Authors: Quinton LJ, Mizgerd JP, Hilliard KL J. Immunol., 2012;188(12):6300-8. Species: Mouse Sample Type: In Vivo Application: Ctrl Cytomegalovirus impairs cytotrophoblast-induced lymphangiogenesis and vascular remodeling in an in vivo human placentation model. Authors: Tabata T, Petitt M, Fang-Hoover J, Rivera J, Nozawa N, Shiboski S, Inoue N, Pereira L Am J Pathol, 2012;181(5):1540-59. Species: Human Sample Type: Whole Cells Application: Ctrl The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat. Med., 2012;18(0):1217. Species: Mouse Sample Type: Whole Tissue Application: Ctrl FcgammaRI mediates serum amyloid P inhibition of fibrocyte differentiation. Authors: Crawford J, Pilling D, Gomer R J Leukoc Biol, 2012;92(4):699-711. Species: Human Sample Type: Whole Cells Application: Ctrl The adaptation of the blood-brain barrier to vascular endothelial growth factor and placental growth factor during pregnancy. Authors: Schreurs MP, Houston EM, May V, Cipolla MJ FASEB J., 2012;26(1):355-62. Species: Rat Sample Type: In Vivo Application: Ctrl Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Authors: Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, Yamada SD, Peter ME, Gwin K, Lengyel E Nat. Med., 2011;17(11):1498-503. Species: Mouse Sample Type: In Vivo Application: Ctrl The immune-modulating cytokine and endogenous Alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation. Authors: Byrne SN, Beaugie C, OSullivan C, Leighton S, Halliday GM Am. J. Pathol., 2011;179(1):211-22. Species: Human Sample Type: Whole Tissue Application: Ctrl Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization. Authors: Liu J, Jha P, Lyzogubov VV, Tytarenko RG, Bora NS, Bora PS J. Biol. Chem., 2011;286(23):20991-1001. Species: Mouse Sample Type: In Vivo Application: Ctrl Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L J. Exp. Med., 2011;208(3):491-503. Species: Mouse Sample Type: Whole Cells Application: Isotype control Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells. Authors: Yamakawa N, Uchida T, Matthay MA, Makita K Am. J. Physiol. Lung Cell Mol. Physiol., 2011;300(4):L516-25. Species: Rat Sample Type: Whole Cells Application: Ctrl The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Authors: Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Despres S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T Nature, 2011;477(7362):90-4. Species: Mouse Sample Type: Whole Cells Application: Ctrl Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Authors: Peters A, Pitcher LA, Sullivan JM, Mitsdoerffer M, Acton SE, Franz B, Wucherpfennig K, Turley S, Carroll MC, Sobel RA, Bettelli E, Kuchroo VK Immunity, 2011;35(6):986-96. Species: Mouse Sample Type: In Vivo Application: Ctrl Inhibitory actions of Anti-Mullerian Hormone (AMH) on ovarian primordial follicle assembly. Authors: Nilsson EE, Schindler R, Savenkova MI, Skinner MK PLoS ONE, 2011;6(5):e20087. Species: Rat Sample Type: Whole Tissue Application: Ctrl Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus. Authors: Noyce RS, Bondre DG, Ha MN PLoS Pathog., 2011;7(8):e1002240. Species: Hamster Sample Type: Whole Cells Application: Ctrl IL-1F5, -F6, -F8, and -F9: A Novel IL-1 Family Signaling System That Is Active in Psoriasis and Promotes Keratinocyte Antimicrobial Peptide Expression. Authors: Johnston A, Xing X, Guzman AM, Riblett M, Loyd CM, Ward NL, Wohn C, Prens EP, Wang F, Maier LE, Kang S, Voorhees JJ, Elder JT, Gudjonsson JE J. Immunol., 2011;186(4):2613-22. Species: Mouse Sample Type: Whole Tissue Application: Ctrl Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma. Authors: Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C PLoS Pathog., 2011;7(4):e1002016. Species: Human Sample Type: Whole Cells Application: Ctrl Irritant-induced migration of Langerhans cells coincides with an IL-10-dependent switch to a macrophage-like phenotype. Authors: Ouwehand K, Oosterhoff D, Breetveld M J. Invest. Dermatol., 2011;131(2):418-25. Species: Human Sample Type: Whole Tissue Application: Ctrl Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling. Authors: Tesio M, Golan K, Corso S Blood, 2011;117(2):419-28. Species: Mouse Sample Type: In Vivo Application: Ctrl IL-27 mediates the response to IFN-beta therapy in multiple sclerosis patients by inhibiting Th17 cells. Authors: Sweeney CM, Lonergan R, Basdeo SA, Kinsella K, Dungan LS, Higgins SC, Kelly PJ, Costelloe L, Tubridy N, Mills KH, Fletcher JM Brain Behav. Immun., 2010;0(0):. Species: Human Sample Type: Whole Cells Application: Ctrl Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation. Authors: Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O Eur. J. Haematol., 2010;84(3):239-51. Species: Human Sample Type: Whole Cells Application: Ctrl Paternal recognition of adult offspring mediated by newly generated CNS neurons. Authors: Mak GK, Weiss S, Nat. Neurosci., 2010;13(6):753-8. Species: Mouse Sample Type: In Vivo Application: Ctrl Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity. Authors: Villani RM, Adolphe C, Palmer J, Waters MJ, Wainwright BJ Cancer Prev Res (Phila), 2010;3(10):1222-34. Species: Mouse Sample Type: Whole Tissue Application: Ctrl Thymic stromal lymphopoietin contributes to myeloid hyperplasia and increased immunoglobulins, but not epidermal hyperplasia, in RabGEF1-deficient mice. Authors: Tsai M, Chen CC, Mukai K Am. J. Pathol., 2010;177(5):2411-20. Species: Mouse Sample Type: Whole Tissue Application: Ctrl Interleukin-1beta mediates the extra-intestinal thrombosis associated with experimental colitis. Authors: Yoshida H, Russell J, Senchenkova EY, Almeida Paula LD, Granger DN Am. J. Pathol., 2010;177(6):2774-81. Species: Mouse Sample Type: In Vivo Application: Ctrl Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Authors: Eidenschenk C, Crozat K, Krebs P, Arens R, Popkin D, Arnold CN, Blasius AL, Benedict CA, Moresco EM, Xia Y, Beutler B Proc. Natl. Acad. Sci. U.S.A., 2010;107(21):9759-64. Species: Mouse Sample Type: In Vivo Application: Ctrl Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. Authors: Caldwell JM, Blanchard C, Collins MH, Putnam PE, Kaul A, Aceves SS, Bouska CA, Rothenberg ME J. Allergy Clin. Immunol., 2010;125(4):879-888. Species: Human Sample Type: Whole Tissue Application: Ctrl The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor. Authors: Hudecek M, Schmitt TM, Baskar S Blood, 2010;116(22):4532-41. Species: Human Sample Type: Whole Cells Application: Ctrl IL-33 is produced by mast cells and regulates IgE-dependent inflammation. Authors: Hsu CL, Neilsen CV, Bryce PJ PLoS ONE, 2010;5(8):e11944. Species: Mouse Sample Type: Whole Cells Application: Ctrl A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa. Authors: Kotarsky K, Sitnik KM, Stenstad H, Kotarsky H, Schmidtchen A, Koslowski M, Wehkamp J, Agace WW Mucosal Immunol, 2010;3(1):40-8. Species: Mouse Sample Type: Whole Tissue Application: Ctrl Chemerin peptides promote phagocytosis in a ChemR23- and Syk-dependent manner. Authors: Cash JL, Christian AR, Greaves DR J. Immunol., 2010;184(9):5315-24. Species: Mouse Sample Type: In Vivo Application: Ctrl GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. Authors: Shiozawa Y, Pedersen EA, Taichman RS Exp. Hematol., 2010;38(2):132-40. Species: Human Sample Type: Whole Cells Application: Ctrl Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation. Authors: Maeda T, Kiguchi N, Kobayashi Y, Ikuta T, Ozaki M, Kishioka S Proc. Natl. Acad. Sci. U.S.A., 2009;106(31):13076-81. Species: Mouse Sample Type: In Vivo Application: Ctrl Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Authors: Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ Proc. Natl. Acad. Sci. U.S.A., 2009;106(14):5954-9. Species: Mouse Sample Type: In Vivo Application: Ctrl Vascular endothelial growth factor-induced chemotaxis and IL-10 from T cells. Authors: Shin JY, Yoon IH, Kim JS, Kim B, Park CG Cell. Immunol., 2009;256(1):72-8. Species: Mouse Sample Type: Whole Cells Application: Ctrl Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression. Authors: Fujimoto H, Sangai T, Ishii G, Ikehara A, Nagashima T, Miyazaki M, Ochiai A Int. J. Cancer, 2009;125(6):1276-84. Species: Mouse Sample Type: In Vivo Application: Ctrl Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. Authors: St John AL, Abraham SN Nat. Med., 2009;15(11):1259-65. Species: Mouse Sample Type: In Vivo Application: Ctrl Long term oncostatin M treatment induces an osteocyte-like differentiation on osteosarcoma and calvaria cells. Authors: Brounais B, David E, Chipoy C, Trichet V, Ferre V, Charrier C, Duplomb L, Berreur M, Redini F, Heymann D, Blanchard F Bone, 2009;44(5):830-9. Species: Mouse Sample Type: Cell Lysates Application: Ctrl Atropine-enhanced, antigen challenge-induced airway hyperreactivity in guinea pigs is mediated by eosinophils and nerve growth factor. Authors: Verbout NG, Jacoby DB, Gleich GJ, Fryer AD Am. J. Physiol. Lung Cell Mol. Physiol., 2009;297(2):L228-37. Species: Guinea Pig Sample Type: In Vivo Application: Ctrl The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Authors: Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R Eur. J. Immunol., 2009;39(12):3570-81. Species: Human Sample Type: Whole Cells Application: Ctrl CCR7-CCL19/CCL21-regulated dendritic cells are responsible for effectiveness of sublingual vaccination. Authors: Song JH, Kim JI, Kwon HJ, Shim DH, Parajuli N, Cuburu N, Czerkinsky C, Kweon MN J. Immunol., 2009;182(11):6851-60. Species: Mouse Sample Type: In Vivo Application: Ctrl Uropathogenic Escherichia coli-induced inflammation alters mouse urinary bladder contraction via an interleukin-6-activated inducible nitric oxide synthase-related pathway. Authors: Weng TI, Wu HY, Lin PY, Liu SH Infect. Immun., 2009;77(8):3312-9. Species: Mouse Sample Type: In Vivo Application: Ctrl Mature antigen-experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint. Arthritis Rheum., 2008;58(0):3377-87. Species: Human Sample Type: Whole Tissue Application: Ctrl Fibroblast-type reticular stromal cells regulate the lymph node vasculature. Authors: Chyou S, Ekland EH, Carpenter AC, Tzeng TC, Tian S, Michaud M, Madri JA, Lu TT J. Immunol., 2008;181(6):3887-96. Species: Mouse Sample Type: In Vivo Application: Ctrl CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis. Authors: Ouwehand K, Santegoets SJ, Bruynzeel DP, Scheper RJ, de Gruijl TD, Gibbs S Eur. J. Immunol., 2008;38(11):3050-9. Species: Human Sample Type: Ex Vivo Application: Ctrl Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo. Authors: Sakatani S, Seto-Ohshima A, Shinohara Y, Yamamoto Y, Yamamoto H, Itohara S, Hirase H J. Neurosci., 2008;28(43):10928-36. Species: Mouse Sample Type: In Vivo Application: Ctrl BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Authors: Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V Blood, 2008;112(8):3154-63. Species: Human Sample Type: Whole Cells Application: Ctrl Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor alpha2 in vivo. Authors: Chen W, Tabata Y, Gibson AM, Daines MO, Warrier MR, Wills-Karp M, Hershey GK J. Allergy Clin. Immunol., 2008;122(3):625-32. Species: Mouse Sample Type: Whole Cells Application: Ctrl Overexpression of CXCL16 and its receptor CXCR6/Bonzo promotes growth of human schwannomas. Authors: Held-Feindt J, Rehmke B, Mentlein R, Hattermann K, Knerlich F, Hugo HH, Ludwig A, Mehdorn HM Glia, 2008;56(7):764-74. Species: Human Sample Type: Whole Cells Application: Ctrl Trauma and hemorrhage-induced acute hepatic insulin resistance: dominant role of tumor necrosis factor-alpha. Authors: Xu J, Kim HT, Ma Y, Zhao L, Zhai L, Kokorina N, Wang P, Messina JL Endocrinology, 2008;149(5):2369-82. Species: Rat Sample Type: In Vivo Application: Ctrl Regulation of scar formation by vascular endothelial growth factor. Authors: Wilgus TA, Ferreira AM, Oberyszyn TM, Bergdall VK, DiPietro LA Lab. Invest., 2008;88(6):579-90. Species: Mouse Sample Type: In Vivo Application: Ctrl The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice. Authors: Kiguchi N, Maeda T, Kobayashi Y, Kondo T, Ozaki M, Kishioka S Eur. J. Pharmacol., 2008;592(1):87-92. Species: Mouse Sample Type: In Vivo Application: Ctrl The secretory leukocyte protease inhibitor (SLPI) and the secondary granule protein lactoferrin are synthesized in myelocytes, colocalize in subcellular fractions of neutrophils, and are coreleased by activated neutrophils. Authors: Jacobsen LC, Sorensen OE, Cowland JB, Borregaard N, Theilgaard-Monch K J. Leukoc. Biol., 2008;83(5):1155-64. Species: Human Sample Type: Whole Cells Application: Ctrl Distribution of the receptor for advanced glycation end products in the human male reproductive tract: prevalence in men with diabetes mellitus. Authors: Mallidis C, Agbaje I, Rogers D, Glenn J, McCullough S, Atkinson AB, Steger K, Stitt A, McClure N Hum. Reprod., 2007;22(8):2169-77. Species: Human Sample Type: Whole Tissue Application: Ctrl Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1. Authors: Crocker SJ, Frausto RF, Whitmire JK, Benning N, Milner R, Whitton JL Am. J. Pathol., 2007;171(6):1762-73. Species: Mouse Sample Type: In Vivo Application: Ctrl Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Authors: Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N Nature, 2007;450(7171):825-31. Species: Mouse Sample Type: Cell Lysates Application: Ctrl IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells. Authors: Gleissner CA, Zastrow A, Klingenberg R, Kluger MS, Konstandin M, Celik S, Haemmerling S, Shankar V, Giese T, Katus HA, Dengler TJ Eur. J. Immunol., 2007;37(1):177-92. Species: Human Sample Type: Whole Cells Application: Ctrl 12-O-tetradecanoyl phorbol 13-acetate induces the expression of B7-DC, -H1, -H2, and -H3 in K562 cells. Authors: Jang BC, Park YK, Choi IH, Kim SP, Hwang JB, Baek WK, Suh MH, Mun KC, Suh SI Int. J. Oncol., 2007;31(6):1439-47. Species: Human Sample Type: Whole Cells Application: Ctrl Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions. Authors: Advani A, Kelly DJ, Advani SL, Cox AJ, Thai K, Zhang Y, White KE, Gow RM, Marshall SM, Steer BM, Marsden PA, Rakoczy PE, Gilbert RE Proc. Natl. Acad. Sci. U.S.A., 2007;104(36):14448-53. Species: Rat Sample Type: In Vivo Application: Ctrl Vascular-derived artemin: a determinant of vascular sympathetic innervation? Authors: Damon DH, Teriele JA, Marko SB Am. J. Physiol. Heart Circ. Physiol., 2007;293(1):H266-73. Species: Rat Sample Type: Whole Cells Application: Ctrl Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage. Authors: Yang S, Hu S, Choudhry MA, Rue LW, Bland KI, Chaudry IH J. Mol. Cell. Cardiol., 2007;42(3):620-30. Species: Rat Sample Type: Application: Ctrl Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. Authors: Xanthou G, Alissafi T, Semitekolou M, Simoes DC, Economidou E, Gaga M, Lambrecht BN, Lloyd CM, Panoutsakopoulou V Nat. Med., 2007;13(5):570-8.
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Authors: Clark AK, Yip PK, Grist J, Gentry C, Staniland AA, Marchand F, Dehvari M, Wotherspoon G, Winter J, Ullah J, Bevan S, Malcangio M Proc. Natl. Acad. Sci. U.S.A., 2007;104(25):10655-60. Species: Rat Sample Type: In Vivo Application: Ctrl Bronchial epithelial cell growth regulation in fibroblast cocultures: the role of hepatocyte growth factor. Authors: Skibinski G, Elborn JS, Ennis M Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(1):L69-76. Species: Human Sample Type: Whole Cells Application: Ctrl The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade. Authors: Fuller GL, Williams JA, Tomlinson MG, Eble JA, Hanna SL, Pohlmann S, Suzuki-Inoue K, Ozaki Y, Watson SP, Pearce AC J. Biol. Chem., 2007;282(17):12397-409. Species: Chicken Sample Type: Whole Cells Application: Ctrl Erythropoietin promotes survival of retinal ganglion cells in DBA/2J glaucoma mice. Authors: Zhong L, Bradley J, Schubert W, Ahmed E, Adamis AP, Shima DT, Robinson GS, Ng YS Invest. Ophthalmol. Vis. Sci., 2007;48(3):1212-8. Species: Mouse Sample Type: Whole Tissue Application: Ctrl T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissue. Authors: Withers DR, Fiorini C, Fischer RT, Ettinger R, Lipsky PE, Grammer AC Blood, 2007;109(11):4856-64. Species: Human Sample Type: Whole Cells Application: Ctrl Enhancement of glucose transporter expression of brain endothelial cells by vascular endothelial growth factor derived from glioma exposed to hypoxia. Authors: Yeh WL, Lin CJ, Fu WM Mol. Pharmacol., 2007;73(1):170-7. Species: Rat Sample Type: Whole Cells Application: Ctrl IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. Authors: Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA J. Immunol., 2007;178(4):2018-27. Species: Mouse Sample Type: Whole Cells Application: Ctrl Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation. Authors: Chandrasekar B, Patel DN, Mummidi S, Kim JW, Clark RA, Valente AJ J. Biol. Chem., 2007;283(7):4200-9. Species: Mouse Sample Type: Cell Culture Supernates Application: Ctrl CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses. Authors: Calvert JG, Slade DE, Shields SL, Jolie R, Mannan RM, Ankenbauer RG, Welch SK J. Virol., 2007;81(14):7371-9. Species: Primate - Macaca mulatta (Rhesus monkey) Sample Type: Whole Cells Application: Ctrl The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation. Authors: Zarbock A, Schmolke M, Bockhorn SG, Scharte M, Buschmann K, Ley K, Singbartl K Crit. Care Med., 2007;35(9):2156-63. Species: Mouse Sample Type: In Vivo Application: Ctrl Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth. Authors: Chen H, Gordon MS, Campbell RA, Li M, Wang CS, Lee HJ, Sanchez E, Manyak SJ, Gui D, Shalitin D, Said J, Chang Y, Deuel TF, Baritaki S, Bonavida B, Berenson JR Blood, 2007;110(1):287-95. Species: Human Sample Type: Whole Cells Application: Ctrl Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor. Authors: Colston JT, de la Rosa SD, Koehler M, Gonzales K, Mestril R, Freeman GL, Bailey SR, Chandrasekar B Am. J. Physiol. Heart Circ. Physiol., 2007;293(3):H1839-46. Species: Rat Sample Type: Whole Cells Application: Ctrl Junctional adhesion molecule 1 is a functional receptor for feline calicivirus. Authors: Makino A, Shimojima M, Miyazawa T, Kato K, Tohya Y, Akashi H J. Virol., 2006;80(9):4482-90. Species: Human Sample Type: Whole Cells Application: Ctrl Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes. Authors: Koelle DM, Huang J, Hensel MT, McClurkan CL J. Virol., 2006;80(6):2863-72. Species: Human Sample Type: Whole Cells Application: Ctrl Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration. Authors: Li Y, Fan J, Chen M, Li W, Woodley DT J. Invest. Dermatol., 2006;126(9):2096-105. Species: Human Sample Type: Serum Application: Ctrl Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions. Authors: Cahill RA, Wang JH, Soohkai S, Redmond HP Surgery, 2006;140(1):108-12. Species: Mouse Sample Type: In Vivo Application: Ctrl Apoptotic neutrophils release macrophage migration inhibitory factor upon stimulation with tumor necrosis factor-alpha. Authors: Daryadel A, Grifone RF, Simon HU, Yousefi S J. Biol. Chem., 2006;281(37):27653-61. Species: Human Sample Type: Whole Cells Application: Ctrl TLR4-NOX4-AP-1 signaling mediates lipopolysaccharide-induced CXCR6 expression in human aortic smooth muscle cells. Authors: Patel DN, Bailey SR, Gresham JK, Schuchman DB, Shelhamer JH, Goldstein BJ, Foxwell BM, Stemerman MB, Maranchie JK, Valente AJ, Mummidi S, Chandrasekar B Biochem. Biophys. Res. Commun., 2006;347(4):1113-20. Species: Human Sample Type: Whole Cells Application: Ctrl Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Authors: Nguyen AN, Stebbins EG, Henson M, O'Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS Exp. Cell Res., 2006;312(10):1909-23. Species: Human Sample Type: Whole Cells Application: Ctrl Mechanism of IL-6-mediated cardiac dysfunction following trauma-hemorrhage. Authors: Yang S, Hu S, Hsieh YC, Choudhry MA, Rue LW, Bland KI, Chaudry IH J. Mol. Cell. Cardiol., 2006;40(4):570-9. Species: Rat Sample Type: Application: Ctrl Induction of interleukin-6 by hepatitis C virus core protein in hepatitis C-associated mixed cryoglobulinemia and B-cell non-Hodgkins lymphoma. Authors: Feldmann G, Nischalke HD, Nattermann J, Banas B, Berg T, Teschendorf C, Schmiegel W, Duhrsen U, Halangk J, Iwan A, Sauerbruch T, Caselmann WH, Spengler U Clin. Cancer Res., 2006;12(15):4491-8. Species: Human Sample Type: Whole Cells Application: Ctrl CCL2 regulates angiogenesis via activation of Ets-1 transcription factor. Authors: Stamatovic SM, Keep RF, Mostarica-Stojkovic M, Andjelkovic AV J. Immunol., 2006;177(4):2651-61. Species: Mouse Sample Type: Whole Cells Application: Ctrl Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2. Authors: Sakamoto E, Hato F, Kato T, Sakamoto C, Akahori M, Hino M, Kitagawa S J. Leukoc. Biol., 2005;78(1):301-9. Species: Human Sample Type: Whole Cells Application: Ctrl Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses. Authors: Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA J. Thromb. Haemost., 2005;3(4):733-41. Species: Human Sample Type: Whole Cells Application: Neut The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts. Authors: Puxeddu I, Bader R, Piliponsky AM, Reich R, Levi-Schaffer F, Berkman N J. Allergy Clin. Immunol., 2005;117(1):103-10. Species: Human Sample Type: Whole Cells Application: Ctrl Immunosuppressive effects of CCL17 on pulmonary antifungal responses during pulmonary invasive aspergillosis. Authors: Carpenter KJ, Hogaboam CM Infect. Immun., 2005;73(11):7198-207. Species: Mouse Sample Type: Application: Ctrl Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism. Authors: Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, Kufe D J. Immunol., 2005;174(4):2376-86. Species: Human Sample Type: Whole Cells Application: Ctrl Requirement for intercellular adhesion molecule 1 and caveolae in invasion of human oral epithelial cells by Porphyromonas gingivalis. Authors: Tamai R, Asai Y, Ogawa T Infect. Immun., 2005;73(10):6290-8. Species: Human Sample Type: Whole Cells Application: Ctrl Variation in macrophage-migration-inhibitory-factor immunoreactivity during porcine gestation. Authors: Paulesu L, Cateni C, Romagnoli R, Ietta F, Dantzer V Biol. Reprod., 2005;72(4):949-53. Species: Human Sample Type: Whole Tissue Application: Ctrl Protection of human conjunctival fibroblasts from NO-induced apoptosis by interleukin-4 or interleukin-13. Authors: Fujitsu Y, Fukuda K, Kimura K, Seki K, Kumagai N, Nishida T Invest. Ophthalmol. Vis. Sci., 2005;46(3):797-802. Species: Human Sample Type: Whole Cells Application: Flow Maladaptive role of IL-6 in ischemic acute renal failure. Authors: Kielar ML, John R, Bennett M J. Am. Soc. Nephrol., 2005;16(11):3315-25. Species: Mouse Sample Type: In Vivo Application: Ctrl IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. Authors: Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H J. Immunol., 2005;175(9):6177-89. Species: Human Sample Type: Whole Tissue Application: Ctrl Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages. Authors: Emori Y, Ikeda T, Ohashi T, Masuda T, Kurimoto T, Takei M, Kannagi M J. Gen. Virol., 2004;85(0):2603-13. Species: Human Sample Type: Whole Cells Application: Neut Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. Authors: Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA J. Immunol., 2004;172(9):5213-21. Species: Human Sample Type: Whole Cells Application: Ctrl Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. Authors: Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ J. Immunol., 2004;172(9):5753-64. Species: Primate - Macaca mulatta (Rhesus monkey) Sample Type: Whole Cells Application: Ctrl Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype. Authors: Leach RE, Kilburn B, Wang J, Liu Z, Romero R, Armant DR Dev. Biol., 2004;266(2):223-37. Species: Human Sample Type: Whole Cells Application: Ctrl Interleukin 11 advances progesterone-induced decidualization of human endometrial stromal cells. Authors: Dimitriadis E, Robb L, Salamonsen LA Mol. Hum. Reprod., 2002;8(7):636-43. Species: Human Sample Type: Whole Cells Application: Ctrl Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Authors: Cashman J, Clark-Lewis I, Eaves A, Eaves C Blood, 2002;99(3):792-9. Species: Human Sample Type: Whole Cells Application: Ctrl Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment. Authors: Janatpour MJ, Hudak S, Sathe M, McEvoy LM J. Exp. Med., 2001;194(9):1375-84. Species: Mouse Sample Type: In Vivo Application: Ctrl LeIF: a recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile. Authors: Skeiky YA, Kennedy M, Kaufman D J. Immunol., 1998;161(11):6171-9. Species: Mouse Sample Type: Whole Cells Application: Ctrl |