Phospho-c-Jun (Ser73) (D47G9) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate)
货号：
12714S 基本售价：
4460.0 元 规格：
100ul
产品信息
概述| 货号 | 12714S |
| 反应种属 | Human/Mouse/Rat/Monkey/Pig |
| 来源宿主 | Rabbit |
| 应用 | F |
| 使用方法 | F(1:50) |
性能| 供应商 | CST |
| 标记 | Alexa Fluor 488 |
| 背景 | c-Jun is a member of the Jun family containing c-Jun, JunB, and JunD, and is a component of the transcription factor activator protein-1 (AP-1). AP-1 is composed of dimers of Fos, Jun, and ATF family members and binds to and activates transcription at TRE/AP-1 elements (reviewed in 1). Extracellular signals including growth factors, chemokines, and stress activate AP-1-dependent transcription. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK (reviewed in 2). Knock-out studies in mice have shown that c-Jun is essential for embryogenesis (3), and subsequent studies have demonstrated roles for c-Jun in various tissues and developmental processes including axon regeneration (4), liver regeneration (5), and T cell development (6). AP-1 regulated genes exert diverse biological functions including cell proliferation, differentiation, and apoptosis, as well as transformation, invasion and metastasis, depending on cell type and context (7-9). Other target genes regulate survival, as well as hypoxia and angiogenesis (8,10). Research studies have implicated c-Jun as a promising therapeutic target for cancer, vascular remodeling, acute inflammation, and rheumatoid arthritis (11,12). |
| 存放说明 | 4C |
参考图片Flow cytometric analysis of HeLa cells, untreated (blue) or UV-treated (green), using Phospho-c-Jun (Ser73) (D47G9) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate). |
