LIN28A (D1A1A) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate)
货号：
12573S 基本售价：
4264.0 元 规格：
100ul
产品信息
概述| 货号 | 12573S |
| 描述 | This Cell Signaling Technology antibody is conjugated to Alexa Fluor® 488 fluorescent dye and tested in-house for direct flow cytometry analysis in human cells. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated LIN28A (D1A1A) XP® Rabbit mAb #8641. |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | IF-IC/F |
| 使用方法 | F(1:50)
IF-IC (1:200) |
性能| 供应商 | CST |
| 标记 | Alexa Fluor 488 |
| 背景 | LIN28A and LIN28B are conserved, developmentally regulated RNA binding proteins that inhibit the processing and maturation of the let-7 family of miRNAs (1,2). The let-7 miRNAs have been implicated in repression of oncogenes such as Ras, Myc, and HMGA2 (3). It has recently been shown that upregulation of LIN28A and LIN28B in primary human tumors and human cancer cell lines is correlated with downregulation of let-7 miRNAs (4). LIN28 genes are reported to be involved in primordial germ cell development and germ cell malignancy (5). In addition, allelic variation in LIN28B is associated with regulating the timing of puberty in humans (6). Overexpression of LIN28A, in conjunction with Oct-4, Sox2, and Nanog, can reprogram human fibroblasts to pluripotent, ES-like cells (7). |
| 存放说明 | 4C |
参考图片 |
Immunofluorescent analysis of NTERA -2 cl.D1 (left) and HeLa (right) cells using Lin28A (D1A1A) XP® (Alexa Fluor® 488 Conjugate) Rabbit mAb (green). Pseudocolor blue = DRAQ5® #4084 (fluorescent DNA dye). |
