Aiolos (D1C1E) Rabbit mAb (PE Conjugate)
货号：
21799S 基本售价：
4060.0 元 规格：
100ul
产品信息
概述| 货号 | 21799S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit IgG |
| 应用 | F |
| 使用方法 | F(1:50) |
性能| 供应商 | CST |
| 背景 | Aiolos is an Ikaros family transcription factor composed of several zinc fingers that mediate DNA binding and homodimerization or heterodimerization with other Ikaros family members (1). Multiple Aiolos isoforms are generated through alternative splicing of the portion of the transcript encoding the amino-terminal zinc fingers (2). Aiolos is expressed by lymphoid tissues, with highest expression levels seen in mature B and T cells (1). Ikaros family proteins control lymphocyte development by recruiting chromatin remodeling complexes to DNA (3). B cells from mice lacking Aiolos have a reduced threshold for activation, increased proliferation, and elevated levels of IgG and IgE. In addition, Aiolos null mice develop B cell lymphomas (4). In T cells, Aiolos contributes to Th17 cell differentiation by suppressing IL-2 expression (5). Aberrant expression of Aiolos in transformed epithelial cells promotes anchorage independence through downregulation of adhesion-related genes (6). Alterations in the Aiolos gene are observed in near haploid acute lymphoblastic leukemia, and the genetic locus containing Aiolos is linked to increased susceptibility to rheumatoid arthritis and systemic lupus erythematosus (7-9). |
| 存放说明 | 4C |
参考图片Flow cytometric analysis of U-937 cells (blue), untreated RPMI 8226 cells (green), or lenalidomide-treated RPMI 8226 cells (2 µM, 24 hr; red), using Aiolos (D1C1E) Rabbit mAb (PE Conjugate). |
