Non-phospho (Active) β-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
货号：
13537S 基本售价：
4060.0 元 规格：
100ul
产品信息
概述| 货号 | 13537S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | F |
| 使用方法 | F(1:50) |
性能| 供应商 | CST |
| 标记 | PE |
| 背景 | β-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8). |
| 存放说明 | 4C |
参考图片Flow cytometric analysis of K-562 cells, untreated (blue) or treated with CHIR99021 (3 μM, 48 hr) (green) using Non-phospho (Active) β-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate). |
