Phospho-IKKα/β (Ser176/180) (16A6) Rabbit mAb (PE Conjugate)
货号：
14938S 基本售价：
4060.0 元 规格：
100ul
产品信息
概述| 货号 | 14938S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit IgG |
| 应用 | F |
| 使用方法 | F(1:50) |
性能| 供应商 | CST |
| 标记 | PE? |
| 背景 | The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins (1-3). Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB (3-7). The key regulatory step in this pathway involves activation of a high molecular weight IκB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit (8,9). Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation (10-13). |
| 存放说明 | 4C |
参考图片Flow cytometric analysis of THP-1 cells, untreated (blue) or treated with TPA #4174 (80 nM, overnight followed by a 24 hr rest) and LPS (1 μg/ml, 15 min; green), using Phospho-IKK-α/β (Ser176/Ser180) (16A6) Rabbit mAb (PE Conjugate). |
