Phospho-SAPK/JNK (Thr183/Tyr185) (G9) Mouse mAb (PE Conjugate)
货号：
5755S 基本售价：
4060.0 元 规格：
100ul
产品信息
概述| 货号 | 5755S |
| 反应种属 | Human/Mouse/Rat/Hamster/S.cerevisiae |
| 来源宿主 | Mouse |
| 应用 | F |
| 使用方法 | F(1:50) |
性能| 供应商 | CST |
| 标记 | PE |
| 背景 | The stress-activated protein kinase/Jun-amino-terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses including UV and gamma radiation, ceramides, inflammatory cytokines, and in some instances, by growth factors and GPCR agonists (1-6). As with the other MAPKs, the core signaling unit is composed of a MAPKKK, typically MEKK1-MEKK4, or by one of the mixed lineage kinases (MLKs), which phosphorylate and activate MKK4/7. Upon activation, MKKs phosphorylate and activate the SAPK/JNK kinase (2). Stress signals are delivered to this cascade by small GTPases of the Rho family (Rac, Rho, cdc42) (3). Both Rac1 and cdc42 mediate the stimulation of MEKKs and MLKs (3). Alternatively, MKK4/7 can be activated in a GTPase-independent mechanism via stimulation of a germinal center kinase (GCK) family member (4). There are three SAPK/JNK genes each of which undergoes alternative splicing resulting in numerous isoforms (3). SAPK/JNK, when active as a dimer, can translocate to the nucleus and regulate transcription through its effects on c-Jun, ATF-2, and other transcription factors (3,5). |
| 存放说明 | 4C |
参考图片Flow cytometric analysis of THP-1 cells, untreated (blue) or anisomycin-treated (green), using Phospho-SAPK/JNK (Thr183/Tyr185) (G9) Mouse mAb (PE Conjugate).流式细胞方法检测未处理（蓝色）和茴香霉素处理（绿色）的THP-1细胞，蓝色为未处理组，绿色为处理组。使用抗体为Phospho-SAPK/JNK (Thr183/Tyr185) (G9) Mouse mAb (连接PE)。 |
