Survivin (71G4B7) Rabbit mAb (Alexa Fluor® 647 Conjugate)
货号：
2866S 基本售价：
4060.0 元 规格：
100ul
产品信息
概述| 货号 | 2866S |
| 描述 | Cell Signaling Technology antibody is conjugated to Alexa Fluor® 647 fluorescent dye and tested in-house for direct flow cytometric analysis of human cells. The unconjugated antibody, #2808 reacts with survivin from human, mouse, and rat. CST expects that Survivin (71G4E) Rabbit mAb (Alexa Fluor® 647 Conjugate) will also recognize survivin in these species. |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | F |
| 使用方法 | F(1:50) |
性能| 供应商 | CST |
| 标记 | Alexa Fluor 647 |
| 背景 | Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy (1). Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle by inhibiting apoptosis and promoting cell division (2,3). This regulatory process requires the phosphorylation of survivin at Thr34 by p34 cdc2 kinase (4). Gene targeting using a Thr34 phosphorylation-defective survivin mutant, as well as antisense survivin, have been shown to inhibit tumor growth (5,6). |
| 存放说明 | 4C |
参考图片Flow cytometric analysis of untreated Jurkat cells, using Survivin (71G4E) Rabbit mAb (Alexa Fluor® 647 Conjugate) in the absence of blocking peptide (green) or in the presence of Survivin Blocking Peptide #1037 (blue), compared to a nonspecific control antibody #3452 (red). 流式细胞仪检测未处理Jurkat细胞，无blocking peptide（绿色）或有Survivin Blocking Peptide #1037 （蓝色）处理 ，使用抗体为Survivin (71G4) Rabbit mAb (Alexa Fluor® 647 conjugate)兔单抗， 一个非特异性抗体#3452 （红色）作为对照。 |
