Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb【科瑞奥博】

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Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb

货号： 8082S 基本售价： 3980.0 元规格： 100ul

产品信息

概述
货号	8082S
反应种属	Human/Mouse
来源宿主	Rabbit
应用	W/F
目标/特异性	Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb recognizes endogenous levels of Jak2 protein only when phosphorylated at Tyr1008. This antibody also reacts with Jak2 when dually phosphorylated at Tyr1007 and Tyr1008. Cross-reactivity was not observed with other Jak family members by western blot.
使用方法	WB(1:1000) F (1:400)

性能
供应商	CST
背景	Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains.
存放说明	-20C
计算分子量	125

参考图片

Western blot analysis of extracts from BaF3 cells, untreated or treated with Mouse Interleukin-3 (mIL-3) #8923 (10 ng/ml, 5 min), using Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb (upper) or total Jak2 (D2E12) XP® Rabbit mAb #3230 (lower).Western免疫印迹。用Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb (上图) 或者 total Jak2 (D2E12) XP® Rabbit mAb #3230 (下图)研究未经处理的和经mIL-3 #8923 (10 ng/ml, 5 min) 处理的BaF3细胞的细胞提取液。

Western blot analysis of extracts from LNCaP cells, untreated or treated with growth hormone (GH) (100 ng/ml, 5 min), using Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb (upper) or total Jak2 (D2E12) XP® Rabbit mAb #3230 (lower).Western免疫印迹。用Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb (上图) 或者 total Jak2 (D2E12) XP® Rabbit mAb #3230 (下图)研究未经处理的和经生长素(GH) (100 ng/ml, 5 min), 处理的LNCaP细胞的细胞提取液。

Western blot analysis of extracts from SET-2 cells, untreated or treated with the Jak2 inhibitor FLLL31 (10 μM, 4 hr), using Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb (upper) or total Jak2 (D2E12) XP® Rabbit mAb #3230 (lower).Western免疫印迹。用Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb (上图) 或者 total Jak2 (D2E12) XP® Rabbit mAb #3230 (下图)研究未经处理的和经Jak2抑制剂FLLL31 (10 μM, 4 hr)处理的SET-2细胞的细胞提取液。

Flow cytometric analysis of BaF3 cells, untreated (blue) or treated with Mouse Interleukin-3 (mIL-3) #8923 (green), using Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb.流式细胞仪分析BaF3细胞，未经处理(蓝色)或经过mIL-3 #8923 处理(绿色)，所用抗体为Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb。