Phospho-PZR (Tyr263) (D6A5) Rabbit mAb【科瑞奥博】

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Phospho-PZR (Tyr263) (D6A5) Rabbit mAb

货号： 8088S 基本售价： 3980.0 元规格： 100ul

产品信息

概述
货号	8088S
反应种属	Human/Mouse/Rat/Bovine
来源宿主	Rabbit
应用	W/IP/IF-IC/F
目标/特异性	Phospho-PZR (Tyr263) (D6A5) Rabbit mAb recognizes endogenous levels of PZR protein only when phosphorylated at Tyr263.
使用方法	WB(1:1000) IP (1:50) F (1:6400) IF-IC (1:400)

性能
供应商	CST
背景	PZR (Protein zero related) is an immunoglobulin superfamily protein that specifically binds the tyrosine phosphatase SHP-2 through its intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) (1,2). PZR is phosphorylated by c-Src, c-Fyn, c-Lyn, Csk, and c-Abl (3). PP1, a Src family kinase inhibitor, inhibits PZR phosphorylation (4,5). There are three alternatively spliced isoforms, designated as PZR, PZRa, and PZRb; both PZRa and PZRb lack ITIMs (6,7). PZR is the main receptor of ConA and has an important role in cell signaling via c-Src (4). PZR is expressed in many cell types and is localized to cell contacts and intracellular granules in BAECs and mesothelioma (REN) cells. PZR has been implicated as a cell adhesion protein that may be involved in SHP-2-dependent signaling at interendothelial cell contacts (3). Hypertyrosine phosphorylation of PZR was observed during embryogenesis in a mouse model of Noonan syndrome (8).
存放说明	-20C
计算分子量	30-50

参考图片

Confocal immunofluorescent analysis of BAE cells, untreated (left) or H2O2-treated (2 mM, 30 min; right) using Phospho-PZR (Tyr263) (D6A5) Rabbit mAb (green). Blue pseudocolor= DRAQ5® #4084 (fluorescent DNA dye).未处理（左）或H2O2处理（2 mM，30分钟；右）的BAE细胞，使用Phospho-PZR (Tyr263) (D6A5)兔单抗（绿色）进行激光共聚焦荧光分析。蓝色假色=AQ5® #4084 （DNA荧光染料）。

Western blot analysis of extracts from BAE cells, untreated or H2O2-treated (0.3 mM, 30 min) and untreated HeLa cells, using Phospho-PZR (Tyr263) (D6A5) Rabbit mAb.未处理或经过H2O2处理（0.3mM，30分钟）的BAE细胞和未处理的HeLa细胞提取物，使用 Phospho-PZR (Tyr263) (D6A5) 兔单抗进行western blot分析。

Flow cytometric analysis of BAE cells, untreated (blue) or H2O2-treated (green), using Phospho-PZR (Tyr263) (D6A5) Rabbit mAb.未处理（蓝色）或H2O2处理（绿色）的BAE细胞，使用Phospho-PZR (Tyr263) (D6A5)兔单抗进行流式细胞分析。