| 货号 | 2289S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/F |
| 目标/特异性 | PP5 Antibody detects endogenous levels of total PP5 protein. |
| 使用方法 | WB(1:1000) F (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Protein phosphatase 5 (PP5) is a member of the serine/threonine phosphatase family that also includes PP1, PP2A and PP2B. PP5 uniquely contains an amino-terminal regulatory domain with three tetratricopeptide repeat (TPR) motifs and a carboxy-terminal catalytic domain (1-3). Through the TPR domain, PP5 interacts with a number of proteins and has been reported to be involved in diverse signal transduction pathways, including glucocorticoid receptor signaling, p53-mediated growth arrest, oxidative stress-mediated apoptosis and the response to ionizing radiation-induced DNA damage (4-8).蛋白磷酸酶5 (PP5)是丝氨酸/苏氨酸磷酸酶家族的一员，该家族还包括PP1，PP2A和PP2B。PP5包含异性的氨基末端调节结构域，该结构域具有三个3-4肽重复序列(TPR)模体和一个羧基末端催化结构(1-3)。通过TPR结构域，PP5与一系列蛋白相互作用并被报道参与了各种信号转导途径，包括糖皮质激素受体信号，p53介导的生长捕获，氧化应激介导的细胞凋亡和离子辐射诱导的DNA损伤应答(4-8)。 |
| 存放说明 | -20C |
| 计算分子量 | 58 |
| 参考文献 | 1 . Chen, M.X. and Cohen, P.T. (1997) FEBS Lett. 400, 136-140. 2 . Andreeva, A.V. and Kutuzov, M.A. (1999) Cell. Signal. 11, 555-562. 3 . Chinkers, M. Trends Endocrinol. Metab. 12, 28-32. 4 . Zuo, Z. et al. (1998) J. Biol. Chem. 273, 12250-12258. 5 . Morita, K. et al. (2001) EMBO J. 20, 6028-6036. 6 . Silverstein, A.M. et al. (1997) J. Biol. Chem. 272, 16224-16230. 7 . Ali, A. et al. (2004) Genes Dev. 18, 249-254. 8 . Wechsler, T. et al. (2004) Proc. Natl. Acad. Sci. USA 101, 1247-1252. |
Flow cytometric analysis of HeLa cells, using PP5 Antibody (blue) compared to a nonspecific negative control antibody (red).流式细胞术检测Hela细胞，使用的抗体为 PP5 Antibody (蓝色)，非特异性阴性对照抗体（红色）作为对照。 | |
Western blot analysis of extracts from 293, NIH/3T3 and PC12 cells, using PP5 Antibody.Western blot方法检测293, NIH/3T3 和PC12细胞，使用的抗体为PP5 Antibody. |
