| 货号 | 4989S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/F |
| 目标/特异性 | Catenin δ-1 Antibody detects endogenous levels of total catenin δ-1 protein. |
| 使用方法 | WB(1:1000) F (1:50) |
| 供应商 | CST |
| 背景 | Catenin δ-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function (1). Catenin δ-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin δ-1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin δ-1, which modulates RhoA, Rac, and cdc42 proteins (1). Analogous to β-catenin, catenin δ-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin δ-1 may function as a tumor suppressor (4). |
| 存放说明 | -20C |
| 计算分子量 | 100 |
Western blot analysis of extracts from MDA-MB-231 and NIH/3T3 cells using Catenin δ-1 Antibody.使用Catenin δ-1抗体对MDA-MB-231 和NIH/3T3 细胞提取物进行western blot分析。 | |
Flow cytometric analysis of NIH/3T3 cells, using Catenin δ-1 Antibody (blue) compared to a nonspecifc negative control antibody (red).使用Catenin δ-1抗体（蓝色）和对照的非特异性阴性对照抗体（红色）对NIH/3T3细胞进行流失细胞分析。 |
