| 货号 | 3662S |
| 反应种属 | Human/Mouse/Rat/Monkey/Bovine |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IHC-P/IF-IC/F |
| 目标/特异性 | Acetyl CoA Carboxylase Antibody detects endogenous levels of all isoforms of acetyl CoA carboxylase protein. |
| 使用方法 | WB(1:1000) IP (1:50) IHC-P (1:100) F (1:50) IF-IC (1:50) |
| 供应商 | CST |
| 背景 | Acetyl-CoA carboxylase (ACC) catalyzes the pivotal step of the fatty acid synthesis pathway. The 265 kDa ACCα (ACC1) is the predominant isoform found in liver, adipocytes, and mammary gland, while the 280 kDa ACCβ (ACC2) is the major isoform in skeletal muscle and heart (1). Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC (2). ACC is a potential target of anti-obesity drugs (3,4). |
| 存放说明 | -20C |
| 计算分子量 | 280 |
Confocal microscopic images of A431 cells showing cytoplasmic stain with Acetyl CoA Carboxylase Antibody (A) compared to an isotype control (B). A431细胞的激光共聚焦图像，显示胞质被Acetyl CoA Carboxylase Antibody（A）染色，B为阴性对照 | |
Western blot analysis of extracts from 293, HeLa, A431, NIH/3T3, L929, C6, H-4-IIE and BAEC cells, using Acetyl CoA Carboxylase Antibody. Wetern blot检测 293, HeLa, A431, NIH/3T3, L929, C6, H-4-IIE 和BAEC 细胞提取物，所用抗体为Acetyl CoA Carboxylase Antibody。 | |
Flow cytometric analysis of untreated HeLa cells, using Acetyl CoA Carboxylase Antibody (blue) compared to a nonspecific negative control antibody (red). 流式细胞检测未处理的Hela细胞系,所用抗体为Acetyl CoA Carboxylase Antibody（蓝）, 对照为非特异性阴性抗体（红） |
