| 货号 | 9104S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Mouse |
| 应用 | W/IF-F/IF-IC/F |
| 目标/特异性 | CREB (86B10) Mouse mAb detects endogenous levels of total CREB protein. |
| 使用方法 | WB(1:1000) F (1:100) IF-F (1:200) IF-IC (1:200) |
| 供应商 | CST |
| 背景 | CREB is a bZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations (1-3). Additionally, CREB signaling is involved in learning and memory in several organisms (4-6). CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2 (7-9). |
| 存放说明 | -20C |
| 计算分子量 | 43 |
Confocal microscopic images of SK-N-MC cells showing nuclear stain with CREB (86B10) Mouse mAb (red). Blue pseudocolor = DRAQ5 (fluorescent DNA dye). | |
SK-N-MC细胞的共聚焦显微图像显示细胞核染色（红色），使用的抗体是CREB (86B10) Mouse mAb 鼠单抗。蓝色伪彩=DRAQ5(荧光DNA染料)。 |
