| 货号 | IC7640S-100UG |
| 别名 | Gm287; hgnc31753; TLR11; Toll like receptor 11 | 全称 | Toll-like Receptor 11 |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects mouse TLR11 in direct ELISAs. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 239081 (Mouse); 498491 (Rat) |
| 免疫原 | E. coli-derived recombinant mouse TLR11 Thr209-Gln325 Accession # Q6R5P0 |
| 生物活性 | Mouse |
| 标记 | Alexa Fluor 750 |
| 背景 | TLR11 is a type I transmembrane receptor of the Toll-like receptor family that is primarily expressed in epithelial cells, but also in dendritic cells and macrophages. The 926 amino acid (aa) mouse TLR11 transcript encodes a 30 aa signal sequence, a 691 aa extracellular domain with 10 leucine-rich repeats and 9 potential N-glycosylation sites, a 21 aa transmembrane domain, and a 184 aa cytoplasmic domain with a TIR domain. Within the region used as an immunogen, mouse and rat TLR11 share 86% aa sequence identity. Human TLR11 is a pseudogene that is not expressed. TLR11 resides in the endoplasmic reticulum (ER), interacts with the multispan ER protein UNC93B1, recognizes profilin-like proteins on Toxoplasma gondii and other intracellular parasites, and activates dendritic cell IL-12 production. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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