| 货号 | FAB7775S-100UG |
| 别名 | Siglec-10; SiglecG; Siglec-G | 全称 | Sialic Acid Binding Ig-like Lectin G |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects mouse Siglec-G in ELISAs. In direct ELISAs, no cross-reactivity with recombinantmouse Siglec-F or recombinant human Siglec-10 is observed. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 243958 (Mouse) |
| 免疫原 | Chinese hamster ovary cell line CHO-derived recombinant mouse Siglec-G Glu20-Gln525 Accession # NP_766488 |
| 生物活性 | Mouse |
| 标记 | Alexa Fluor 750 |
| 背景 | Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by a V-type Ig-like domain which mediates sialic acid binding, followed by varying numbers of C2-type Ig-like domains. Mouse Siglec-G, the apparent ortholog of human Siglec-10, is a 110-120 kDa, 688 amino acid (aa) type I transmembrane protein mainly expressed on mouse B1-type B cells. It controls B1 cell survival, selection, expansion and calcium signaling by negatively regulating B cell receptor signals. A potentially secreted 269 aa variant diverges after the first two Ig-like domains. Mouse Siglec-G shares approximately 63% aa sequence identity with human Siglec-10 within the extracellular domain. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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