| 货号 | FAB6524S-100UG |
| 别名 | CO-029; tetraspanin 8; TM4SF3; TM4SF3tspan-8; Transmembrane 4 superfamily member 3tetraspanin-8; TSPAN8; Tspan-8; Tumor-associated antigen CO-029 | 全称 | Tetraspanin 8/Transmembrane 4 Superfamily, Member 3 |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects mouse TSPAN8 transfectants but not the parental cell line in flow cytometry. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 7103 (Human); 216350 (Mouse); 171048 (Rat) |
| 免疫原 | CHO Chinese hamster ovary cell line transfected with mouse TSPAN8 |
| 生物活性 | Mouse |
| 标记 | Alexa Fluor 750 |
| 背景 | Tetraspanin-8 (TSPAN8), also known as TM4SF3 and human tumor-associated antigen CO-0029, is a member of the transmembrane 4 (tetraspanin) superfamily. It is a cell surface 27 - 34 kDa protein with intracellular N- and C-termini, 4 transmembrane segments and a large extracellular loop (LEL) domain from aa 106-206. TSPAN8 is involved in integrin-mediated cell motility, metastasis, cell proliferation and differentiation, and is over-expressed in carcinomas including hepatocellular carcinoma and colon cancer. Polymorphisms have variably been associated with type II diabetes, bipolar disorder and schizophrenia. Human TSPAN8 shares 70% aa sequence identity with mouse and rat TSPAN8. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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