| 货号 | FAB2754S-100UG |
| 别名 | LILRB3; PIRB; PIR-B | 全称 | Paired-Ig-like Receptor B |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects mouse PIR-B in direct ELISAs and Western blots. In Western blots, this antibody does not cross-react with recombinant mouse PIR‑A. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 18733 (Mouse); 65146 (Rat) |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant mouse PIR-B Gly24-Gly635 Accession # AAH26937 |
| 生物活性 | Mouse |
| 标记 | Alexa Fluor 750 |
| 背景 | Mouse PIR-B is a 125 kDa type I transmembrane glycoprotein with six Ig-like domains in its extracellular domain (ECD) and four ITIM-like sequences in its cytoplasmic domain. The ECD of PIR-B is highly homologous to the ECDs of multiple mouse PIR-A receptors (92-99% amino acid sequence homology), which have short cytoplasmic tails lacking ITIM motifs. PIR-A receptors have a charged residue in their transmembrane domain that facilitates interaction with ITAM-containing adaptor molecules. Whereas PIR-A receptors deliver activation signals, PIR-B can inhibit receptor-mediated activation signaling. PIR-A and PIR-B have been shown to bind various mouse MHC class I molecules. They have been proposed to be orthologs of human leukocyte immunoglobulin-like receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
|