| 货号 | FAB567T-100UG |
| 别名 | MGC126574; neuropilin 2; Neuropilin2; Neuropilin-2; neuropilin-2a(22); neuropilin-2b(0); NP2; NPN 2; NPN2; PRO2714; receptor for VEGF165 and semaphorins class3; Vascular endothelial cell growth factor 165 receptor 2; vascular endothelial growth factor-165 receptor 2; VEGF1265R2; VEGF165R2neuropilin-2a(17) |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects rat Neuropilin-2 in direct ELISAs and detects human, mouse, and rat Neuropilin-2 in Western blots. In direct ELISAs and Western blots, this antibody does not cross-react with recombinant human Neuropilin‑1. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 8828 (Human); 18187 (Mouse); 81527 (Rat) |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant rat Neuropilin‑2 Gln23-Asp857 (Val809-Asp825 del) Accession # O35276 |
| 生物活性 | Human, Mouse, Rat |
| 标记 | Alexa Fluor 594 |
| 背景 | Neuropilin-1 (Npn-1, previously known as neuropilin) and Npn-2 (previously known as Npn-1-related molecule) are type I transmembrane proteins that bind members of the class III secreted semaphorin subfamily which are implicated in repulsive axon guidance. The extracellular domain of these proteins is composed of two N-terminal CUB (complement-binding) domains (domains a1 and a2), two domains with homology to coagulation factors V and VIII (domains b1 and b2) and a MAM (meprin) domain (domain c). In the absence of ligands, neuropilins can form homo- and hetero-oligomers via homophilic interactions of their MAM domains. At the amino acid sequence level, Npn-1and Npn-2 share 44% identity. Npn-1 and Npn-2 show different binding specificities for different members of the semaphorin family. The expression patterns of Npn-1 and Npn-2 in developing neurons of the central and peripheral nervous systems are largely, though not completely non-overlapping. Npn‑1 and Npn-2 are also expressed by endothelial and tumor cells and have been shown to be isoform-specific receptors for VEGF165. Npn-1 was also reported to bind PlGF-2 and the VEGF-like protein from of virus NZ2. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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