| 货号 | IC5957V-100UG |
| 别名 | KIAA1303; KIAA1303p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats; KOG1; Mip1; p150 target of rapamycin (TOR)-scaffold protein; Raptor; regulatory associated protein of MTOR, complex 1; regulatory-associated protein of mTOR; RPTOR | 全称 | Regulatory Associated Protein of mTOR |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human and mouse RPTOR in Western blots. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | Store the unopened product at 2 - 8 °C. Do not use past expiration date. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 57521 (Human); 74370 (Mouse); 287871 (Rat) |
| 免疫原 | E. coli-derived recombinant human RPTOR Lys77-Gln230 Accession # Q8N122 |
| 生物活性 | Human, Mouse |
| 标记 | Alexa Fluor 405 |
| 背景 | RPTOR (Raptor) is a 150 kDa component of the cytosolic mammalian target of Rapamycin complex 1 (mTORC1) which also contains mTOR and GBL proteins. mTORC1 plays a dominant role in cell cycle regulation in response to metabolic conditions. The interaction of RPTOR with the kinase mTOR is stabilized under conditions of nutrient deprivation and energy stress, leading to inhibition of mTOR and cell cycle arrest. RPTOR contains multiple Ser and Thr residues whose phosphorylation regulates the activation status of mTOR. RPTOR is critical for the response of skeletal muscle and adipose tissue to insulin. It contains three RNC blocks (aa 48-511), three HEAT repeats (aa 550-667), and seven C-terminal WD40 domains (aa 1020-1335). Within aa 77-230, human RPTOR shares 100% aa sequence identity with mouse and rat RPTOR. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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