| 货号 | FAB1639N-100UG |
| 别名 | CLEC5A; CLECSF5; CLECSF5carbohydrate-recognition domain) lectin, superfamilymember 5; C-type lectin domain family 5, member A; C-type lectin superfamily member 5; MDL1; MDL-1; MDL-1MGC138304; Myeloid DAP12-associating lectin 1; myeloid DAP12-associating lectin-1 | 全称 | Myeloid DAP12-associating Lectin |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects mouse MDL-1/CLEC5A. In ELISAs, approximately 50% cross-reactivity with recombinant human MDL‑1 is observed. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 23601 (Human); 23845 (Mouse) |
| 免疫原 | BaF3 mouse pro-B cell line transfected with mouse MDL-1/CLEC5A |
| 生物活性 | Mouse |
| 标记 | Alexa Fluor 700 |
| 背景 | MDL-1 is anapproximately 40 kDa transmembrane glycoprotein belonging to the C-type lectinsuperfamily (CLEC5A). MDL-1 is expressed on immature myeloid cells, monocytes,macrophages, dendritic cells, neutrophils, NK cells, and osteocytes. Itcontains a charged lysine in the transmembrane region that enables it toassociate with DAP12 and deliver an activating signal. MDL-1 mediates inflammatory responses duringautoimmune arthritis and upon binding to Dengue and Japanese encephalitisviruses. The extracellular domain (ECD) of MDL-1 contains a juxtamembrane stalkregion and one C-type lectin domain. Within the ECD, mouse and human MDL-1share 67% amino acid sequence identity. In mouse, alternative splicinggenerates a short isoform with a 25 aa deletion in the stalk region. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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