| 货号 | IC4532T-100UG |
| 简介 | Recombinant Monoclonal Antibody |
| 别名 | CINC1; CINC-1; CXCL1; GRO alpha; KC; MGSA-alpha |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects mouse CXCL1/GRO alpha /KC/CINC‑1 in direct ELISAs. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | Store the unopened product at 2 - 8 °C. Do not use past expiration date. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 2919 (Human); 14825 (Mouse); 81503 (Rat) |
| 免疫原 | E. coli-derived recombinant mouse CXCL1/GRO alpha /KC/CINC‑1 Asn29-Lys96 Accession # P12850 |
| 生物活性 | Mouse |
| 标记 | Alexa Fluor 594 |
| 背景 | KC, a member of the alpha (CXC) chemokine subfamily, was initially identified as an immediate early gene induced in mouse fibroblasts by platelet‑derived growth factor. KC cDNA encodes a 96 amino acid (aa) residue precursor protein with a predicted secretory signal peptide that is removed to yield the mature protein. The protein sequence of mouse KC shows approximately 63% identity to that of mouse MIP-2. KC is also approximately 60% identical to the human GROs. It has been suggested that mouse KC and MIP-2 are the orthologs of the human GROs and rat CINCs. In addition to mouse fibroblasts, KC is expressed in macrophages and endothelial cells. Mouse KC is a potent neutrophil attractant and activator. The functional receptor for KC has been identified as CXCR2. Based on the pattern of KC expression in a number of inflammatory disease models, KC appears to have an important role in inflammation. KC was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease. Many chemokines are substrates for selective proteolysis at the amino-terminus by various proteases including dipeptidyl peptidase IV or matrix metalloproteases, resulting in truncated chemokine isoforms with different (both enhanced or reduced) bioactivities. The naturally occurring 68 aa N-terminal truncated isoform of mouse KC is reported to be a more potent synergistic growth stimulant for CFU-GM. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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