| 货号 | IC1018N-100UG |
| 别名 | ERK1/ERK2 | 全称 | Extracellular Signal-regulated Kinase 1/2 |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human, mouse, and rat ERK1 and ERK2 dually phosphorylated at T202/Y204 or T185/Y187, respectively. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | Store the unopened product at 2 - 8 °C. Do not use past expiration date. |
| 产品组分 |
| 供应商 | R&D Systems |
| 免疫原 | Phosphopeptide containing ERK1 T202/Y204 site |
| 生物活性 | Human, Mouse, Rat |
| 标记 | Alexa Fluor 700 |
| 背景 | ERK1 and ERK2 (also known as MAPK3 and MAPK1) are 44- and42-kDa Ser/Thr kinases, respectively. They are part of the Ras-Raf-ERK signaltransduction cascade often found downstream of growth factor receptoractivation. ERK1 and ERK2 were initially isolated and cloned as kinasesactivated in response to insulin and NGF. They are expressed in most, if notall, mammalian tissues. Dual threonine and tyrosine phosphorylation activateboth ERKs, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2. The two proteins share 83%amino acid identity, differing mainly at the N and C termini. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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