Mouse CCR2 Phycoerythrin MAb (Clone 475301) (100 TESTS)【科瑞奥博】

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Mouse CCR2 Phycoerythrin MAb (Clone 475301) (100 TESTS)

货号： FAB5538P-100 基本售价： 4659.8 元规格： 100 Tests

产品信息

概述
货号	FAB5538P-100
别名	C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2CKR2B; CCR2; CCR-2; CCR2A; CCR2B; CD192 antigen; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CMKBR2MGC111760; FLJ78302; MCP-1 receptor; MCP-1-RMGC103828; MGC168006; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
反应种属	Mouse/Rat
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects mouse CCR2 transfectants but not the parental cell line in flow cytometry. Does not detect HEK293 human embryonic kidney cell line transfected with mouse CCR5 in flow cytometry.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	729230 (Human); 12772 (Mouse); 60463 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Tumor necrosis factor drives increased splenic monopoiesis in old mice Authors: D Loukov, A Naidoo, A Puchta, JL Marin, DM Bowdish J Leukoc Biol, 2016;0(0):. Species: Mouse Sample Type: Whole Cells Application: Flow Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function Proc Natl Acad Sci USA, 2016;0(0):. Species: Mouse Sample Type: Whole Cells Application: Flow Treatment with cestode parasite antigens recruits CCR2+ myeloid cells, the adoptive transfer of which ameliorates colitis Infect Immun, 2016;0(0):. Species: Mouse Sample Type: Whole Cells Application: Flow Alternatively activated macrophages determine repair of the infarcted adult murine heart J Clin Invest, 2016;0(0):. Species: Mouse Sample Type: Whole Cells Application: Flow AMPK-Activated Protein Kinase Suppresses Ccr2 Expression by Inhibiting the NF-kappaB Pathway in RAW264.7 Macrophages. Authors: Kumase F, Takeuchi K, Morizane Y, Suzuki J, Matsumoto H, Kataoka K, Al-Moujahed A, Maidana D, Miller J, Vavvas D PLoS ONE, 2016;11(1):e0147279. Species: Mouse Sample Type: Whole Cells Application: Flow Development of a pHrodo-based assay for the assessment of in vitro and in vivo erythrophagocytosis during experimental trypanosomosis. Authors: Stijlemans, Benoit, Cnops, Jennifer, Naniima, Peter, Vaast, Axel, Bockstal, Viki, De Baetselier, Patrick, Magez, Stefan PLoS Negl Trop Dis, 2015;9(3):e0003561. Species: Mouse Sample Type: Whole Cells Application: Flow Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis. Authors: Terhorst D, Chelbi R, Wohn C, Malosse C, Tamoutounour S, Jorquera A, Bajenoff M, Dalod M, Malissen B, Henri S J Immunol, 2015;195(10):4953-61. Species: Mouse Sample Type: Whole Cells Application: Flow CD11b is protective in complement-mediated immune complex glomerulonephritis. Authors: Alexander J, Chaves L, Chang A, Jacob A, Ritchie M, Quigg R Kidney Int, 2015;87(5):930-9. Species: Mouse Sample Type: Whole Cells Application: Flow Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasis. Authors: Zheng, Jiao, Yang, Min, Shao, Jianghua, Miao, Yanju, Han, Jiahuai, Du, Jie Mol Cancer, 2013;12(1):141. Species: Mouse Sample Type: Whole Cells Application: Flow Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells. Authors: Yoshimura T, Howard O, Ito T, Kuwabara M, Matsukawa A, Chen K, Liu Y, Liu M, Oppenheim J, Wang J PLoS ONE, 2013;8(3):e58791. Species: Mouse Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	L1.2 mouse pro-B cell line transfected with mouse CCR2
生物活性	Mouse
标记	Phycoerythrin
背景	CCR2, also known as CD192, is a 38 kDa 7TM chemokine receptor that binds CCL2, CCL7, CCL8, CCL12 (in mouse only) and CCL13. CCR2 is expressed by multiple hematopoietic cells plus, endothelial cells, fibroblasts, and smooth muscle cells. It functions as an HIV fusion co-factor and facilitates T cell recruitment during inflammation. Mouse CCR2 shares 67% and 95% aa sequence identity with human and rat CCR2, respectively.
运输条件	Blue Ice
存放说明	4℃
参考文献	CC Chemokines and Receptors Chemokine Receptors Chemokines and Receptors in Allergy and Asthma Chemokines and Receptors in Angiogenesis Human CD Marker Products Macrophage Activation Markers Monocyte Markers Myeloid Lineage Markers Myeloid-derived Suppressor Cells (MDSC) Neuroinflammation Proinflammatory Cytokines & CCR2 Promote Estrogen-deficient Bone Loss Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) T Cell Migration/Adhesion

参考图片

Detection of CCR2 in Mouse Splenocytes byFlow Cytometry. Mouse splenocytes were stained with RatAnti-Mouse CCR2 PE‑conjugated Monoclonal Antibody (Catalog #FAB5538P) and Rat Anti-Mouse Gr‑1/Ly‑6GFluorescein‑conjugated Monoclonal Antibody (Catalog # FAB1037F).Quadrant marker was set based on isotype control antibody staining (Catalog # IC013P). View our protocol for StainingMembrane-associated Proteins.