Mouse CCR2 Alexa Fluor 700 MAb (Clone 475301) (100 TESTS)
货号：
FAB5538N-100 基本售价：
4659.8 元 规格：
100 Tests
产品信息
概述| 货号 | FAB5538N-100 |
| 别名 | C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2CKR2B; CCR2; CCR-2; CCR2A; CCR2B; CD192 antigen; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CMKBR2MGC111760; FLJ78302; MCP-1 receptor; MCP-1-RMGC103828; MGC168006; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor |
| 反应种属 | Mouse/Rat |
| 应用 | Flow Cytometry(5 µL/106cells)
|
| 目标/特异性 | Detects mouse and rat CCR2 transfectants but not the parental cell line in flow cytometry. Does not detect HEK293 human embryonic kidney cell line transfected with mouse CCR5 in flow cytometry. |
| 使用方法 | Flow Cytometry: 5 µL/106cells
|
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 729230 (Human); 12772 (Mouse); 60463 (Rat) |
| 应用文献 |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. HIF-1? is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis
Authors: A Hammami, BM Abidin, T Charpentie, A Fabié, AP Duguay, KM Heinonen, S Stäger
PLoS Pathog., 2017;13(9):e1006616.
Species: Mouse
Sample Type: Whole Cells
Application: Flow
Infection-adapted emergency hematopoiesis promotes visceral leishmaniasis
Authors: BM Abidin, A Hammami, S Stäger, KM Heinonen
PLoS Pathog., 2017;13(8):e1006422.
Species: Mouse
Sample Type: Whole Cells
Application: Flow
Leishmania promastigotes induce cytokine secretion in macrophages through the degradation of synaptotagmin XI.
Authors: Arango Duque G, Fukuda M, Turco S, Stager S, Descoteaux A
J Immunol, 2014;193(5):2363-72.
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| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | L1.2 mouse pro-B cell line transfected with mouse CCR2 |
| 生物活性 | Mouse |
| 标记 | Alexa Fluor 700 |
| 背景 | CCR2, also known as CD192, is a 38 kDa 7TM chemokine receptor that preferentially binds CCL2, CCL7, and CCL13. CCR2 is expressed by multiple hematopoietic cells, endothelial cells, fibroblasts, neurons, and smooth muscle cells. It functions as an HIV fusion co-factor and facilitates T cell recruitment during inflammation. Two alternate splice forms (CCR2A and CCR2B) differ only by the addition of 14 amino acids to the intracellular carboxyl terminal. Mouse CCR2 shares 67% and 95% aa sequence identity with human and rat CCR2, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - CC Chemokines and Receptors
- Chemokine Receptors
- Chemokines and Receptors in Allergy and Asthma
- Chemokines and Receptors in Angiogenesis
- Human CD Marker Products
- Macrophage Activation Markers
- Monocyte Markers
- Myeloid Lineage Markers
- Myeloid-derived Suppressor Cells (MDSC)
- Neuroinflammation
- Proinflammatory Cytokines & CCR2 Promote Estrogen-deficient Bone Loss
- Receptors in the Jak/STAT Pathway
- Regulatory T Cells (Tregs)
- T Cell Migration/Adhesion
|
参考图片Detection of CCR2 in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse CCR2 Alexa Fluor® 700‑conjugated Monoclonal Antibody (Catalog # FAB5538N) and Rat Anti-Mouse Gr‑1/Ly‑6G Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB1037F). Quadrant markers were set based on control antibody staining (Catalog # IC013N). View our protocol for Staining Membrane-associated Proteins. |
