Mouse CCR2 Allophycocyanin MAb (Clone 475301) (100 TESTS)【科瑞奥博】

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Mouse CCR2 Allophycocyanin MAb (Clone 475301) (100 TESTS)

货号： FAB5538A-100 基本售价： 4659.8 元规格： 100 Tests

产品信息

概述
货号	FAB5538A-100
别名	C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2CKR2B; CCR2; CCR-2; CCR2A; CCR2B; CD192 antigen; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CMKBR2MGC111760; FLJ78302; MCP-1 receptor; MCP-1-RMGC103828; MGC168006; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
反应种属	Mouse/Rat
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects mouse CCR2 transfectants but not the parental cell line in flow cytometry. Does not detect HEK293 human embryonic kidney cell line transfected with mouse CCR5 in flow cytometry.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	729230 (Human); 12772 (Mouse); 60463 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Pivotal role for skin trans-endothelial radio-resistant anti-inflammatory macrophages in tissue repair Authors: Olga Barreiro Elife, 2016;5(0):. Species: Mouse Sample Type: Tissue Homogenates Application: Flow Alternatively activated macrophages determine repair of the infarcted adult murine heart J Clin Invest, 2016;0(0):. Species: Mouse Sample Type: Whole Cells Application: Flow Monocyte Trafficking, Engraftment, and Delivery of Nanoparticles and an Exogenous Gene into the Acutely Inflamed Brain Tissue - Evaluations on Monocyte-Based Delivery System for the Central Nervous System PLoS ONE, 2016;11(4):e0154022. Species: Mouse Sample Type: Whole Cells Application: Flow Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice. Authors: Djukic M, Sostmann N, Bertsch T, Mecke M, Nessler S, Manig A, Hanisch U, Triebel J, Bollheimer L, Sieber C, Nau R J Neuroinflammation, 2015;12(0):208. Species: Mouse Sample Type: Tissue Homogenates Application: Flow Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease. Authors: Koyama M, Cheong M, Markey K, Gartlan K, Kuns R, Locke K, Lineburg K, Teal B, Leveque-El Mouttie L, Bunting M, Vuckovic S, Zhang P, Teng M, Varelias A, Tey S, Wockner L, Engwerda C, Smyth M, Belz G, McColl S, MacDonald K, Hill G J Exp Med, 2015;212(8):1303-21. Species: Mouse Sample Type: Whole Cells Application: Flow SHP-1-dependent macrophage differentiation exacerbates virus-induced myositis. Authors: Watson N, Schneider K, Massa P J Immunol, 2015;194(6):2796-809. Species: Mouse Sample Type: Whole Cells Application: Flow RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling. Authors: Patel, Jyoti, McNeill, Eileen, Douglas, Gillian, Hale, Ashley B, de Bono, Joseph, Lee, Regent, Iqbal, Asif J, Regan-Komito, Daniel, Stylianou, Elena, Greaves, David R, Channon, Keith M Nat Commun, 2015;6(0):6614. Species: Mouse Sample Type: Whole Cells Application: Flow Calcitonin gene-related peptide regulates type IV hypersensitivity through dendritic cell functions. Authors: Mikami, Norihisa, Sueda, Kaori, Ogitani, Yusuke, Otani, Ippei, Takatsuji, Miku, Wada, Yasuko, Watanabe, Keiko, Yoshikawa, Rintaro, Nishioka, Satoshi, Hashimoto, Nagisa, Miyagi, Yayoi, Fukada, So-ichir, Yamamoto, Hiroshi, Tsujikawa, Kazutake PLoS ONE, 2014;9(1):e86367. Species: Mouse Sample Type: Whole Cells Application: Flow Transgenic expression of GM-CSF in T cells causes disseminated histiocytosis. Authors: van Nieuwenhuijze A, Coghill E, Gray D, Prato S, Metcalf D, Alexander W, Wicks I Am J Pathol, 2014;184(1):184-99. Species: Mouse Sample Type: whole cells Application: Flow HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. Authors: Schiraldi M, Raucci A, Munoz LM, Livoti E, Celona B, Venereau E, Apuzzo T, De Marchis F, Pedotti M, Bachi A, Thelen M, Varani L, Mellado M, Proudfoot A, Bianchi ME, Uguccioni M J. Exp. Med., 2012;209(3):551-63. Species: Mouse Sample Type: Whole Cells Application: Flow Calcitonin gene-related peptide is an important regulator of cutaneous immunity: effect on dendritic cell and T cell functions. J. Immunol., 2012;186(12):6886-93. Species: Mouse Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	L1.2 mouse pro-B cell line transfected with mouse CCR2
生物活性	Mouse
标记	APC
背景	CCR2, also known as CD192, is a 38 kDa 7TM chemokine receptor that preferentially binds CCL2, CCL7, and CCL13. CCR2 is expressed by multiple hematopoietic cells, endothelial cells, fibroblasts, neurons, and smooth muscle cells. It functions as an HIV fusion co-factor and facilitates T cell recruitment during inflammation. Two alternate splice forms (CCR2A and CCR2B) differ only by the addition of 14 amino acids to the intracellular carboxyl terminal. Mouse CCR2 shares 67% and 95% aa sequence identity with human and rat CCR2, respectively.
运输条件	Blue Ice
存放说明	4℃
参考文献	CC Chemokines and Receptors Chemokine Receptors Chemokines and Receptors in Allergy and Asthma Chemokines and Receptors in Angiogenesis Human CD Marker Products Macrophage Activation Markers Monocyte Markers Myeloid Lineage Markers Myeloid-derived Suppressor Cells (MDSC) Neuroinflammation Proinflammatory Cytokines & CCR2 Promote Estrogen-deficient Bone Loss Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) T Cell Migration/Adhesion

参考图片

Detection of CCR2 in L1.2 Mouse Cell Line Transfected with Mouse CCR2 by Flow Cytometry. L1.2 mouse pro-B cell line transfected with mouse CCR2 was stained with Rat Anti-Mouse CCR2 APC‑conjugated Monoclonal Antibody (Catalog # FAB5538A, filled histogram) or isotype control antibody (Catalog # IC013A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Detection of CCR2 in Mouse Splenocytes byFlow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse CCR2 APC‑conjugated Monoclonal Antibody (Catalog # FAB5538A) and Rat Anti-Mouse Gr‑1/Ly‑6G Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB1037F). View our protocol for Staining Membrane-associated Proteins.