Mouse IL-4 R alpha Phycoerythrin Affinity Purified PAb (100 TESTS)【科瑞奥博】

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Mouse IL-4 R alpha Phycoerythrin Affinity Purified PAb (100 TESTS)

货号： FAB530P-100 基本售价： 4382.2 元规格： 100 Tests

产品信息

概述
货号	FAB530P-100
别名	CD124 antigen; CD124; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL4R; IL-4RA; IL4RACD124; IL-4R-alpha; interleukin 4 receptor; interleukin-4 receptor alpha chain; interleukin-4 receptor subunit alpha
全称	Interleukin 4 Receptor alpha
反应种属	Mouse
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects mouse IL-4 R alpha in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) IL-4 R, rhIL-9 R, rhIL-13 R alpha 1, and recombinant mouse IL-13 R alpha 2 is observed.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3566 (Human); 16190 (Mouse)
纯化方式	Antigen Affinity-purified
免疫原	Mouse myeloma cell line NS0-derived recombinant mouse IL-4 R alpha
生物活性	Mouse
标记	Phycoerythrin
背景	Interleukin 4 is a pleiotropic cytokine produced primarily by activated T cells, mast cells and basophils. The diverse biological effects of IL-4 on a variety of cell types are mediated by the binding of IL-4 to specific cell surface receptors. As is the case with many other cytokines, the functional high-affinity receptor for IL-4 is a complex consisting of a ligand binding subunit ( alpha chain) and a second subunit ( beta chain) that can modulate the ligand binding affinity of the receptor complex. It has been shown that in certain cell types, the gamma chain of the IL-2 receptor is a functional component ( beta chain) of the IL-4 receptor complex. cDNA clones for the ligand binding chain (IL-4 R) of both the mouse and human high affinity IL-4 receptors have been isolated. The human or mouse IL-4R is an approximately 140 kDa transmembrane protein containing an extracellular domain, a transmembrane domain, and a large cytoplasmic domain that is essential for IL-4 signal transduction. In addition to the cDNA clone encoding the full-length transmembrane protein, a second cDNA clone that arises from alternate splicing and that encodes a soluble secreted form of IL-4 R has been isolated from mouse cells, but not yet from human sources. A naturally-occurring soluble form of the IL-4 R has also been identified in mouse biological fluids and murine cell culture supernatants. Native or recombinant murine soluble IL-4 R, as well as recombinant human soluble IL-4 R, can bind IL-4 with the same affinity as the membrane bound IL-4 R. Soluble IL-4 R is a competitive inhibitor of IL-4 and has been shown to neutralize effectively many IL-4-mediated responses both in vivoandin vitro.
运输条件	Blue Ice
存放说明	4℃
参考文献	B Cell Activation B Cell Markers Common gamma Chain Receptor Family Cytokines and Receptors in Allergy and Asthma Cytokines and Receptors in Angiogenesis Cytokines and Receptors in Tfh Cell Differentiation and Function Human CD Marker Products ICC / IHC Images: IL-4 R alpha Interactive Pathway: IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types Interactive Pathway: IL-4 Signaling Pathways Macrophage Activation Markers Myeloid-derived Suppressor Cells (MDSC) Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) T Cell Cytokine Signaling Th17 Cells Th2 Cells Th9 Cells

参考图片

Detection of IL-4 R alpha in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Goat Anti-Mouse IL-4 R alpha PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB530P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.