Human/Mouse TOR Phycoerythrin MAb (Clone 303728) (100 TESTS)【科瑞奥博】

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Human/Mouse TOR Phycoerythrin MAb (Clone 303728) (100 TESTS)

货号： IC1537P 基本售价： 4382.2 元规格： 100 Tests

产品信息

概述
货号	IC1537P
别名	EC 2.7.11.1; FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; FLJ44809; FRAP; FRAP1; FRAP1FKBP12-rapamycin complex-associated protein 1; FRAP2; Mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); Mechanistic target of rapamycin; MTOR; RAFT1; rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; Rapamycin target protein 1; RAPT1FKBP-rapamycin associated protein; serine/threonine-protein kinase mTOR
全称	Mammalian Target of Rapamycin
反应种属	Human/Mouse
应用	Intracellular Staining by Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human TOR in direct ELISAs. Detects human and mouse TOR in flow cytometry.
使用方法	Intracellular Staining by Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	2475 (Human); 287871 (Rat)
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	E. coli-derived recombinant human TOR Phe1720-Ala2020 Accession # P42345
生物活性	Human, Mouse
标记	Phycoerythrin
背景	TOR, also known as FRAP1, is a member of the PI 3-Kinase-related Kinase (PIKK) family. It is the protein target of Rapamycin, an anti-rejection drug used in transplantation and a promising anti-cancer agent. TOR plays a crucial role in the control of cell growth and proliferation as a downstream target of the PI 3-Kinase/Akt signal transduction pathway.
运输条件	Blue Ice
存放说明	4℃
参考文献	A Novel Pathway for TOR-independent Autophagy Regulation by Akt Apoptosis Intracellular Kinases Autophagy Chemokine Receptor Intracellular Signaling Growth Hormone/IGF-I Axis ICC / IHC Images: TOR Interactive Pathway: mTOR Signaling Intracellular Kinases Intracellular Kinases in the Akt Pathway Notch Pathway Parkinsons Disease Related Molecules Positive Regulators of the Jak/STAT Pathway Regulatory T Cells (Tregs) ROS and Stress Resistance

参考图片

Detection of TOR in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) treated with Anti-CD3, Anti-CD28, Recombinant Human TGF‑ beta 1 (Catalog # 240-B), and Recombinant Human IL‑2 (Catalog # 202-IL) were stained with Rat Anti-Human/Mouse TOR PE‑conjugated Monoclonal Antibody (Catalog # IC1537P) and Mouse Anti-Human CD25/IL-2 R alpha APC‑conjugated Monoclonal Antibody (Catalog # FAB1020A). Quadrant markers were set based on control antibody staining (Catalog # IC006P). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules.

Detection of TOR in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes treated with Anti-CD3, Anti-CD28, Recombinant Human TGF‑ beta 1 (Catalog # 240-B), and Recombinant Mouse IL‑2 (Catalog # 402-ML) were stained with Rat Anti-Human/Mouse TOR PE‑conjugated Monoclonal Antibody (Catalog # IC1537P) and Rat Anti-Mouse CD4 PerCP‑conjugated Monoclonal Antibody (Catalog # FAB554C). Quadrant markers were set based on control antibody staining (Catalog # IC006P). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules.