| 货号 | FAB6500V-100UG |
| 别名 | calcitonin receptor-like receptor activity modifying protein 2; Calcitonin-receptor-like receptor activity-modifying protein 2; CRLR activity-modifying protein 2; RAMP2; receptor (calcitonin) activity modifying protein 2; receptor (G protein-coupled) activity modifying protein 2; receptor activity modifying protein 2; receptor activity-modifying protein 2; receptor-activity-modifying protein 2 | 全称 | Receptor Activity Modifying Protein 2 |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects mouse RAMP2 in direct ELISAs. In direct ELISAs, no cross-reactivitywith recombinant human RAMP2 is observed. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 10266 (Human); 54409 (Mouse); 58966 (Rat) |
| 免疫原 | E. coli-derived recombinant mouse RAMP2 Ser45-Val159 Accession # Q9WUP0 |
| 生物活性 | Mouse |
| 标记 | Alexa Fluor 405 |
| 背景 | RAMP2 (receptor activity modifying protein 2) is a 20 kDa member of the RAMP family of proteins. It is expressed on cardiomyocytes, vascular smooth muscle cells and endothelium and interacts with CRLR to form a receptor complex for adrenomedullin (AM). AM induces vasodilation on AM1 receptor expressing cells. Mature mouse RAMP2 is a 145 amino acid (aa) type I transmembrane glycoprotein that contains a 115 aa extracellular domain (ECD) (aa 45-159) and a nine aa cytoplasmic region. Although the ECD contains no typical structural motifs, based on human, aa 100-106 are critical for AM binding. Over aa 45-159, mouse RAMP2 shares 57% and 83% aa identity with human and rat RAMP2, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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