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货号： bs-4241R 基本售价： 780.0 元 规格： 50ul
- 规格：50ul
- 价格：780.00元
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-4241R
- 英文名称
- GLUT8
- 中文名称
- 葡萄糖转运蛋白8抗体
- 别 名
- Glucose Transporter 8; Glucose transporter type 8; Glucose transporter type X1; GLUT-8; GLUT 8; GLUTX1; SLC2A8; solute carrier family 2 (facilitated glucose transporter) member 8.
- Specific References (5) | bs-4241R has been referenced in 5 publications.[IF=3.23] Jackson EE, Rendina-Ruedy E, Smith BJ, Lacombe VA (2015) Loss of Toll-Like Receptor 4 Function Partially Protects against Peripheral and Cardiac Glucose Metabolic Derangements During a Long-Term High-Fat Diet. PLoS ONE 10(11): e0142077. WB ; Mouse.PubMed:26539824[IF=3.23] Maria Z, Campolo AR, Lacombe VA (2015) Diabetes Alters the Expression and Translocation of the Insulin-Sensitive Glucose Transporters 4 and 8 in the Atria. PLoS ONE 10(12): e0146033. WB ; Mouse.PubMed:26720696[IF=3.05] Murakami, Ryuta, et al. "Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells." Histochemistry and Cell Biology (2016):1-6. WB, IHC-P, IHC-F ; Human, Mouse.PubMed:27160096[IF=1.58] Gao, Sujie, et al. "Propofol inhibits growth of neurons through regulating insulin receptor and insulin-like growth factor-1 receptor." Int J Clin Exp Pathol 9.7 (2016): 6785-6794. WB ; Rat.PubMed:0[IF=2.11] Mashima, Masato, et al. "Glucose transporter 8 immunoreactivity in astrocytic and microglial cells in subependymal areas of human brains." Neuroscience Letters (2016). IHC-P ; Human.PubMed:27818355
- 规格价格
- 50ul/780元购买 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 50ul 100ul 200ul
- 研究领域
- 肿瘤 免疫学 信号转导 转运蛋白 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 52kDa
- 细胞定位
- 细胞浆 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GLUT8:401-477/477 <Extracellular>
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Glucose transporter 8 is an insulin-regulated facilitative glucose transporter. It binds cytochalasin B in a glucose-inhibitable manner. It appears to be a dual-specific sugar transporter as it can be inhibited by fructose. It is highly expressed in testis, where it is down-regulated by estrogen, but not in testicular carcinoma. Lower amounts are present in most other tissues.
Subunit:
Interacts with AP2B1.
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration. Insulin induces a change in the intracellular localization and gives rise to insertion in the plasma membrane.
Tissue Specificity:
Highest level of expression in placenta and testis. Highly expressed in adult and pubertal testis, but not prepubertal testis. Lower levels of expression in brain, liver, heart, kidney, fat and skeletal muscle.
Similarity:
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
SWISS:
Q9NY64
Gene ID:
29988
Database links:Entrez Gene: 29988Human
Entrez Gene: 56017Mouse
Entrez Gene: 85256Rat
Omim: 605245Human
SwissProt: Q9NY64Human
SwissProt: Q9JIF3Mouse
SwissProt: Q9JJZ1Rat
Unigene: 179522Human
Unigene: 305754Mouse
Unigene: 12923Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Sample: TM4 Cell (Mouse) Lysate at 40 ug
Primary: Anti- GLUT8 (bs-4241R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52 kD
Observed band size: 52 kD