| 货号 | FAB4054S-100UG |
| 别名 | CD104 antigen; CD104; GP150; Integrin beta 4; integrin beta-4 subunit; integrin beta-4; integrin, beta 4; ITGB4 |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects mouse Integrin beta 4/CD104 in direct ELISAs and Western blots. Does not cross-react with recombinant mouse Integrin beta 1, beta 2, beta 6, beta 7, or recombinant human Integrin beta 3. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 3691 (Human); 192897 (Mouse); 25724 (Rat) |
| 免疫原 | Chinese hamster ovary cell line CHO-derived recombinant mouse Integrin beta 4/CD104 Asn29-Ser711 Accession # NP_001005608 |
| 生物活性 | Mouse |
| 标记 | Alexa Fluor 750 |
| 背景 | Integrin beta 4, also known as CD104, is a 200 kDa type I transmembrane (TM)glycoprotein that associates only with Integrin alpha 6/CD29. Integrin alpha 6 beta 4is predominantly expressed by epithelial cells, binds laminins, and isessential for formation of hemidesmosomes and connection of the dermisto the epidermis. Mouse integrin beta 4 contains a 680 amino acid (aa)extracellular domain (ECD) with a metal-binding site and fourcysteine-rich repeats, a 22 aa TM segment and an unusually long 1073 aacytoplasmic tail that organizes hemidesmosome components. Isoforms withshortened cytoplasmic tails have been described. Mouse and human beta 4 ECDshow 88% aa identity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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