Mouse IL-1 RI Phycoerythrin MAb (Clone 129304) (100 TESTS)【科瑞奥博】

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Mouse IL-1 RI Phycoerythrin MAb (Clone 129304) (100 TESTS)

货号： FAB7712P-100 基本售价： 4243.4 元规格： 100 Tests

产品信息

概述
货号	FAB7712P-100
别名	CD121 antigen-like family member A; CD121a antigen; CD121a; IL1R; IL1R1; IL1RT1; IL-1RT1; IL-1RT-1; Interleukin 1 Receptor 1; interleukin 1 receptor, type I; interleukin receptor 1; interleukin-1 receptor type 1; p80
全称	Interleukin 1 Receptor I
反应种属	Mouse
应用	Flow Cytometry
目标/特异性	Detects mouse IL-1 RI in direct ELISAs and Western blots.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3554 (Human); 16177 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. TLR4-Upregulated IL-1? and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism Sci Rep, 2016;6(0):31663. Species: Mouse Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant mouse IL-1 RI Leu20-Lys338 Accession # P13504
生物活性	Mouse
标记	Phycoerythrin
背景	The type I IL-1 receptor (IL-1 RI, designated IL-1 R1 and CD121a) is one of at least nine members of the IL-1 R family within the Toll/IL-1 R (TIR) superfamily. IL‑1 RI is an ~80 kDa type I transmembrane (TM) protein that binds the pleiotropic cytokines IL-1 alpha and IL-1 beta, plus the IL-1 receptor antagonist (IL-1 Ra). Signal transduction requires complex formation with the IL-1 R accessory protein (IL-1 R AcP/IL-1 R3), another type I TM protein. This complex recruits the adaptor protein MyD88 to initiate signaling in the NF kappa B pathway. Mouse IL-1 RI cDNA encodes a 576 amino acid (aa) protein that contains a 19 aa signal sequence, a 319 aa extracellular domain (ECD) with three C2-type Ig-like domains, a 21 aa TM domain and a 217 aa cytoplasmic region with a TIR domain. Mouse IL-1 RI shares 64%, 83%, 60%, 61% and 55% aa identity with human, rat, canine, equine and bovine IL-1 RI, respectively. The role of IL-1 in inflammation is under several levels of control, including expression and activation of IL-1 alpha and IL-1 beta, expression of IL-1 RI and its accessory and adaptor proteins, and negative regulators such as the IL‑receptor family member, IL-1 RII/IL-1 R2. IL-1 RI is expressed predominantly by T cells, fibroblasts, and endothelial cells and mediates acute phase inflammatory responses including fever.
运输条件	Blue Ice
存放说明	4℃
参考文献	Cytokines and Receptors in Allergy and Asthma Cytokines and Receptors in Angiogenesis Endothelial Cell Markers Group 1 ILCs Human CD Marker Products IL-1 Family Inflammasomes: Intracellular Regulators of Pathogen Interactive Pathway: IL-1 Family Signaling Pathways LTi Cells Mini-review: Interleukin 1 Myeloid-derived Suppressor Cells (MDSC) Natural Killer T (NKT) Cells NCR+ILC3 NCR-ILC3 Neuroinflammation NOD-like Receptors and the Inflammasome Regulatory T Cells (Tregs) T Cell Cytokine Signaling Th17 Cells

参考图片

Detection of IL‑1 RI in Mouse CD3⁺ Splenocytes by Flow Cytometry. Mouse CD3⁺ splenocytes were stained with Rat Anti-Mouse IL‑1 RI PE‑conjugated Monoclonal Antibody (Catalog # FAB7712P, filled histogram) or isotype control antibody (Catalog # IC013P, open histogram). View our protocol for Staining Membrane-associated Proteins.