| 货号 | IC8889T-100UG |
| 简介 | Recombinant Monoclonal Antibody |
| 别名 | EOMES; eomesodermin (Xenopus laevis) homolog; Eomesodermin; t box, brain, 2; T-box brain protein 2; T-box brain2; TBR2; TBR-2; TBR2eomesodermin homolog; T-brain-2 | 全称 | Eomesodermin Homolog |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects mouse EOMES in direct ELISAs. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | Store the unopened product at 2 - 8 °C. Do not use past expiration date. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 8320 (Human); 13813 (Mouse); 316052 (Rat) |
| 免疫原 | E. coli-derived recombinant mouse EOMES Met1-Ser126 Accession # O54839 |
| 生物活性 | Mouse |
| 标记 | Alexa Fluor 594 |
| 背景 | EOMES (Eomesodermin), also TBR2, is a 72 kDa member of the TBR1 subfamily, T-box family of transcription factors. It is expressed in NK and CD8+ T cells, where CTLA4 activation suppresses EOMES activation of IFN-gamma and granzyme B genes. It is also found in the embryo, where it occurs in forebrain floorplate and migrating neuroblasts at 12.5 weeks gestation. Notably, it is reported to undergo intercellular transfer in fetal Xenopus tissue destined to become mesoderm. Here, it synchronizes a multicellular commitment to a cell lineage. Human EOMES is 686 amino acids (aa) in length. It contains short poly-Ala, -Gly and -Asn motifs, and a DNA-binding T box (aa 276-456). There is one isoform that shows a 19 aa insertion after Ser460. Over aa 471‑686, human EOMES shares 91% aa identity with mouse EOMES. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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