| 货号 | FAB8998N-100UG |
| 简介 | Recombinant Monoclonal Antibody |
| 别名 | 17-1A; 323/A3; ACSTD1; antigen identified by monoclonal AUA1; CD326 antigen; CD326; Cell surface glycoprotein Trop-1; chromosome 4, surface marker (35kD glycoprotein); DIAR5; EGP; EGP-2; EGP314; EGP40; EpCAM; epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein 314; Epithelial glycoprotein; ESA; GA733-2; GA733-2EGP34; gp40; hEGP314; HNPCC8; KS 1/4 antigen; KS1/4; KSAHEA125; M1S2; M4S1; M4S1Ly74; Major gastrointestinal tumor-associated protein GA733-2; MIC18MH99; MOC31; TACST-1; TACSTD1; TROP1; TROP1CD326; Tumor-associated calcium signal transducer 1CO-17A | 全称 | Epithelial Cell Adhesion Molecule |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects mouse EpCAM/TROP-1. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | Store the unopened product at 2 - 8 °C. Do not use past expiration date. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 4072 (Human); 17075 (Mouse) |
| 免疫原 | TE-71 Thymic epithelial cell line |
| 生物活性 | Mouse |
| 标记 | Alexa Fluor 700 |
| 背景 | Epithelial Cellular AdhesionMolecule (EpCAM), also known as EGP314 (Epithelial glycoprotein 314), TACSTD1(tumor-associated calcium signal transducer 1) and CD326 is a 292 amino acid(aa), 40 kDa transmembrane glycoprotein composed of a 243 aa extracellulardomain with two epidermal-growth-factor-like (EGF-like) repeats within thecysteine-rich N-terminal region, a 23 aa transmembrane domain, and a 26 aacytoplasmic domain. Human and mouse EpCAM share 82% aa sequence identity.During embryonic development, EpCAM is detected in fetal lung, kidney, liver,pancreas, skin, and germ cells. EpCAM has been shown function as a homophilicCa2+ independent adhesion molecule (1). Homophilic adhesion viaEpCAM requires the interaction of both EGF-like repeats, with the firstEGF-like repeat mediating reciprocal interaction between EpCAM molecules onopposing cells, while the second repeat is involved in lateral interaction ofEpCAM. Lateral interaction of EpCAM lead to the formation of dimers andtetramers (2). During homophilic adhesion the cytoplasmic tail of EpCAMinteracts with the actin cytoskeleton via a direct association alpha -actinin (3). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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